.no-italic {
    font-style: normal;
}
.cnvtonormaltxt {
	display: inline-block;
    transform: skewX(21deg);
    padding-right: 2px;
    margin-left: -3px;
}
.profound .section-navigator > a:nth-child(2)  >em:nth-child(2){
	margin-right: 3px;
}
.hrrm-testing .mobile p.telephone-cont span > a{
	text-decoration: none;
}
.monotherapy.dosing.dosing-page .solo-heading .dosing-fnt {
	font-family: 'Roboto-BlackItalic' !important;
    letter-spacing: -0.5px;
}
.treatment-paradigm  .container-center.lynp-indic{
	display: none;
}
.treatment-paradigm .othertreatment{
	text-align: center;
    margin-bottom: 30px;
}
.treatment-paradigm .container-center.lynp-indic h4{
	color: #004D74;
    font-size: 20px;
    font-family: 'Roboto-Bold';
    line-height: 22px;
}
.container-center.lynp-indic{
	margin-top: 30px;
    padding: 0 20px;
} 
.profound  .Primary_endpoint .recommend .recommend_platinum, 
.profound  .secondary_endpoint .recommend .recommend_platinum, 
.profound  .secondary_endpointPFS .recommend .recommend_platinum{
	    background: none;
}

.profound  .Primary_endpoint .recommend .recommend_based, 
.profound  .secondary_endpoint .recommend .recommend_based, 
.profound  .secondary_endpointPFS .recommend .recommend_based{
	color: #004D74;
}
.profound .Primary_endpoint .container-center h2,
.profound .secondary_endpoint .container-center h2{
	color: #ffffff;
    margin: 26px 0;
        transform: skewX(10deg);
}
.monotherapy3 .Primary_endpoint h2 {
    font-size: 30px;
}
.profound .container-center.skew-maroon-head{
	    background-color: #801852;
    padding: 6px 35px;
        transform: skewX(170deg);
            width: fit-content;
    /*max-width: fit-content;*/
    margin: 10px auto 20px;

}
.monotherapy3 .container-center.skew-maroon-head{

   /* padding: 6px 30px; */

}

.profound .Primary_endpoint .container-center.skew-maroon-head{
	width: fit-content;
}
.monotherapy3 .Primary_endpoint .container-center.skew-maroon-head{
	/*width: inherit;*/
}
.profound .orr-a,
.profound .orr-ab{
        margin-bottom: 40px;  
       padding: 14px 10px;
}
.profound .cohort-container.cohort-container12 { margin-left : 27px; }
.profound .cohort-container.cohort-container12 .orr-a {
   margin-left : 13px;
    padding-right: 5px !important;
}
.profound .orr-a h2,
.profound .orr-ab h2{
	color: #801852;
	font-size: 30px;
}
.profound .orr-a p.cohort-txt,
.profound .orr-ab p.cohort-txt{
	font-size: 18px;
    line-height: 22px;
    padding: 0 86px 0 30px;
    transform: skewX(10deg);
}
.cohort-txt.sk-new.sk-new-l {padding-right: 90px;}
.profound .orr-a p.cohort-foot,
.profound .orr-ab p.cohort-foot{
	font-size: 16px;
    padding: 0 40px 0 40px;
    transform: skewX(10deg);
}
.cohort-foot.sk-new.sk-new-l2{padding-right: 86px !important;}
.profound .cohort-container{
	border-left: 6px solid #801852;
    transform: skewX(170deg);
    width: 100%;
    max-width: 942px;
    margin: 0 auto;
    background: #EBDCE6;
}
.profound .cohort-container.cohort-container2 { margin-left: 35px;}
.profound .orr-a h2, 
.profound .orr-ab h2{
	transform: skewX(10deg);
    margin-bottom: 15px;
}
.profound .orr-ab p,
.profound .orr-a p{
	margin-bottom: 8px;
        color: #0F4269;
}
.profound .orr-ab p.cohort-foot:last-child{
	padding-left: 50px;
    font-size: 15px;
    text-indent: -7px;
    line-height: 16px !important;
}
.orr-ab p.cohort-txt:nth-child(3) {
    padding-left: 44px;
}


.orr-ab p.cohort-foot:nth-child(4) {
    padding-left: 54px;
}

.profound .orr-ab p.cohort-foot:last-child {
    padding-left: 62px;}

.profound .orr-a h2,
.profound .orr-ab h2{
	padding-left: 18px;
	margin: 15px 0 10px 0;
}
.profound .secondary_endpointPFS .recommend .recommend_platinum{
	margin-bottom: 15px;
}
.hrrm-testing .biopsywrap .biopsycontent .listcontent{
	color: #000000;
}
.profound  .profound-pros{
	clear: both;
    margin-bottom: 40px;
}
.Primary_endpoint .recommend .recommend_platinum, 
.secondary_endpoint .recommend .recommend_platinum, 
.secondary_endpointPFS .recommend .recommend_platinum{
	margin-bottom: 15px;
}
.recommend_platinum.width52 {margin-bottom: 5px!important;}
.profound .profound-pros > p {
    padding: 0 18px 0 23px;
}
.monotherapy .reference {
    padding: 0 20px 0 10px;
}
.profound .hoc-analysis{
	font-family: 'Roboto-Regular';
}
.profound .Primary_endpoint_chart.desktop{
	margin-bottom: 30px;
}
.profound .secondary_endpointOS.Primary_endpoint {
    margin-top: 40px;
}
.PROfound_wrap.desktop h2{
	font-size: 20px;
}
.PROfound_wrap .robotbold18txt{
	font-size: 20px !important;
}
.hrrm-testing .footnote{
	font-size: 16px !important;
}
.hrrm-testing .section-navigator > a{
	color: #000000;
    border-bottom: 1px solid #000000;
        font-family: 'Roboto-Regular';
}
.hrrm-testing .section-navigator > a:hover{text-decoration: none;}
.hrrm-testing .head-gudieline h2,
.hrrm-testing .when-test h2,
.hrrm-testing .how-test h2,
.hrrm-testing .when-test p,
.hrrm-testing p.why-test-desc,
.hrrm-testing .why-test h2{
	color: #004D74;
	font-family: 'Roboto-Bold';
}
.hrrm-testing .hrrm-foot-note p{
	font-family: 'Roboto-Regular';
        text-indent: -7px;
}
.hrrm-testing p.telephone-cont{
	font-family: 'Roboto-Bold';
	color: #004D74;
}
.hrrm-testing p.telephone-cont a{
	text-decoration: underline;
	color: #004D74;
}
.hrrm-testing .biopsywrap .basedtxt{
	color: #000000;
    margin-left: 15px;
}
.hrrm-testing .biopsywrap .wheretxt{
	font-family: 'Roboto-Bold';
}

.hrrm-testing .section-three .footnotecontiner .footnote{
	color: #58595B !important;
}
.hrrm-testing .prognastic .recommend .flex{
	align-items: center;
}
.hrrm-testing .recommend_based{
	color: #000000;
    font-family: 'Roboto-Medium';
}
.hrrm-testing p.thick-txt-head{
	font-family: 'Roboto-Bold';
}
.hrrm-testing .guideline-txt-2 p.thick-txt-head+p{
	text-indent: -7px;
}
.section-two.how-and-when p	{
    font-family: 'Roboto-Bold';
    color: #004D74;

}		
.section-two.how-and-when h2 {
    color: #004D74;
    font-family: 'Roboto-Bold';
    margin-top: 0;
}
.dosing .daily-dose-rec-container .dose-head {
	background-color: #004D74;
        transform: skewX(170deg);
    margin-left: 3px;
}
.dosing .daily-dose-rec-container .dose-head p{
	color: #FFFFFF;
	text-align: center;
	font-family: 'Roboto-Bold' !important;
        transform: skewX(10deg);
    margin-bottom: 0;
}
.dosing .dosing-callouts{
	background-color: #FFFFFF;
}
.dosing .daily-dose-rec-container .dosage-body-flex{
	background-color: #D5E7F560;
}
.dosing  .mgmt-options-container .mgmt-opt-flex,
.dosing .daily-dose-rec-container .dosage-body-flex{
	display: flex;
}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic span,
.dosing .daily-dose-rec-container .dosage-body-flex .recomended-dose-txt p:first-child{
	font-family: 'Roboto-Bold' !important;
}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic span,
.dosing p.act-size-txt,
.dosing .daily-dose-rec-container .dosage-body-flex .recomended-dose-txt p{
	color: #004D74;
}
.dosing span.maroon-highlit{
	color: #801852;
}
.dosing  .mgmt-options-container > div:first-child p{
	font-family: 'Roboto-Bold' !important;
	color: #004D74;
}

.dosing .mgmt-head{
	background-color: #B2D234;
    transform: skewX(170deg);
    margin-left: 3px;
    margin-bottom: 2px;
}
.dosing .mgmt-head > p{
	font-family: 'Roboto-Bold' !important;
	color: #004D74;
        transform: skewX(10deg);
    text-align: center;
}
.dosing .dose-interrupts .dose-int-body,
.dosing .dose-reduces .dose-red-body{
	background-color: #B2D23430;
}
.dosing  .mgmt-options-container p,
.dosing .or-connect span{
	font-family: 'Roboto-Bold' !important;
    color: #004D74;
}
.dosing .mgmt-options-container p.final-dose-txt,
.dosing .mgmt-options-container p.init-dose-txt{
	font-family: 'Roboto-Regular' !important;
}
.dosing .mgmt-options-container .init-reduce,
.dosing .mgmt-options-container .final-reduce{
	display: flex;
}
.dosing .dosing-callouts .or p{
	color: #004D74;
}
.dosing .dosing-end-tag p{
	margin-bottom: 0;
	font-family: 'Roboto-Bold' !important;
	color: #004D74;	
    transform: skewX(10deg);
}
.dosing .dosing-end-tag {
    margin: 0 auto;
    background: #B2D23440;
        transform: skewX(170deg);
}


.patient-profiles .magenta_eyebrow {
    background-color: #801852;
    font-family: 'Roboto-Bold';
    font-size: 20px;
    color: #FFFFFF;
    /* padding: 72px 0 67px 0; */
    text-align: left;
    padding-top: 50px;
    padding-bottom: 50px;
}
.patient-profiles .pat-detail img.desktop{
	max-width: 300px;
}
.patient-profiles .pat-detail h4{
	color: #801852;
    font-family: 'Roboto-Bold';
}
.patient-profiles .pat-detail .curr-age{
	color: #004D74;
	font-family: 'Roboto-Bold';
}

.patient-profiles p.fact-head{
	color: #801852;
	font-family: 'Roboto-Bold';
}
.patient-profiles .med-facts {
    color: #58595B;
}

.patient-profiles .joe-history,
.patient-profiles .william-history{
	    border-left: 1px solid #B2D234;
    padding: 0 72px 0 25px;
}

.patient-profiles p.fact-head::before{
	content: '\f111';
    /*font-size: 15px;*/
    height: 15px;
    width: 15px;
    position: relative;
    left: -20px;
    top: 0px;
    font-family: 'FontAwesome';
}
.patient-profiles .end-banner-patient p{
	color: #004D74;
	font-family: 'Roboto-Bold';
}
.marginbottom20.color-blk {
    color: #000!important;
}
.patient-profiles .end-banner-patient .william-opt,
.patient-profiles .end-banner-patient .joe-opt{
	background-color: #B2D234;
}
.hrrm-testing h2.container-center sup,
.treatment-paradigm .pink_eyebrow h2 sup,
.patient-profiles  h2.container-center sup{
	position: relative;
	top: -10px;
	left: 5px;

}
.dosing-page #maincontent h1 sup{
    position: relative; 
     font-family: 'Roboto-Black';
	/*top: -12px;*/
    top: -9px;
	/*left: 1px; */
}
.dosing-page #maincontent h1 sup.sup {
    position: relative;
    top: -7px;
    left: 0px;
}
p.robotbold18txt.patient-blue {
    font-family: 'Roboto-Bold';
}




/****desktop-body****/
@media (min-width: 768px){
.home .callouts {
    margin: 4.5% 3% 0 0;
}
p.robotbold18txt.patient-blue {
    font-size: 20px;
    line-height: 23px;
}
.secondary_endpointPFS .recommend .recommend_platinum .recommend_based, .secondary_endpointOS.Primary_endpoint .recommend .recommend_based {font-size: 25px;}

.home .callouts .callout{
	width: 209px;
	height: 77px;
    opacity: 0.8;
}
.home .callouts .callout span,
.home .callouts .callout p{
	font-size: 13px;
}
.home .callouts a.callout:first-child p{
	margin-top: 17px;
}
.container-center.lynp-indic{
    padding: 0 10px;
} 
.profound .section-navigator{
    margin: 10px 0 17px 0;
}
.profound .section-navigator > a{
	font-size: 17px;
	line-height: 23px;
	text-align: left;
	font-family: 'Roboto-Regular';
	color: #000000;
    /*text-decoration: underline;*/
    margin: 0 15px 0 0;
    border-bottom: 1px solid #000000;
}
.profound .PROfound_wrap .section-navigator > a:hover, a:active, a:visited, a:focus {text-decoration: none;}
.prostrate_efficacy .Primary_endpoint .recommend .recommend_platinum{
	width: 75%;
}
}

@media (min-width: 1024px){
.profound .section-navigator{
	white-space: nowrap;
}	
	
}





@media (max-width: 767px){
.efficacy .isi .isi-body{
	padding-top: 98px !important;
}    
.home .m-callouts{
	margin-top: 0;
}
p.robotbold18txt.patient-blue {
    /*font-size: 13px;
    line-height: 16px;*/
    font-size: 16px;
    line-height: 20px;
}
.patient-profiles .common-page-title{
	margin-top: -28px;
}
.patient-profiles .magenta_eyebrow p.container-center{
	margin-top: 30px;
}
.prostrate_efficacy .common-page-title{
	margin-top: -23px;
}
.prostrate_efficacy .magenta_eyebrow p.container-center{
	margin-top: 30px;
}  
.prostrate_efficacy .common-page-title p{
	padding: 5px 0 !important;
}    
}




@media (max-width: 1023px){
.home .m-callouts .m-callout{
    background-color: #801852;
}

}


/*****Nav part ******/
@media (min-width: 1004px){

.fullnavigation ul.dropdown-menu.multi-level li:last-child{
	    box-shadow: 0px 3px 6px #00000029;
}            
.fullnavigation .navbar li.about-lynparza {
	position: relative;

}
.fullnavigation .navbar li.about-lynparza ul.dropdown-menu li{
    max-width: 240px;
    width: 240px;
}
.fullnavigation .navbar li.about-lynparza ul.dropdown-menu li>a{ 
        font-family: 'Roboto-Regular';
    color: #FFFFFF;
    white-space: normal;
    text-align: left; 
}  
.fullnavigation .navbar-default .navbar-nav>li{
	margin: 0 10px 0 10px;
}
.fullnavigation .navbar li.about-lynparza.submenu ul{
	display: none;
}
.navbar li.about-lynparza:hover ul{
	display: block !important;
}

}        



/*************BODY DESKTOP********************/
@media (min-width: 992px){

.recommendImg img {
    padding-right: 33px;
}

.section-two.how-and-when h2 {
    font-size: 36px;
}
.hrrm-testing .section-two.how-and-when {
    /*margin-top: 47px;*/
    margin-top: 68px;
    /*margin-bottom: 60px;*/
     /*margin-bottom: 24px;*/
}
 .section-two.how-and-when .flex_container_brca.container-center {
    padding-right: 0;
}

.prostrate_efficacy .magenta_eyebrow p.container-center{
	line-height: 20px;
}
.PROfound_wrap.desktop h2{
	margin-bottom: 0;
}
.PROfound_wrap.desktop h3.centerAlign{
	padding-top: 0;
}
.PROfound_wrap.desktop img{
	padding-top: 37px;
    padding-bottom: 37px;
}
.profound .Primary_endpoint .container-center h2, .profound .secondary_endpoint .container-center h2 {
    line-height: 30px;
}
.profound .orr-a h2, .profound .orr-ab h2{
	line-height: 22px;
}
p.cohort-txt.sk-new.sk-new-orr-n {
    padding: 0 92px 0 30px;
}

.profound em.pval{
	margin-right: 2px;
}
.profound .orr-ab p.cohort-foot:last-child,
.profound .orr-a p.cohort-foot,.orr-ab p.cohort-foot:nth-child(4){
	font-size: 15px !important;
	line-height: 16px !important;
}
.profound .orr-ab p.cohort-foot{
	font-size: 16px;
	line-height: 18px;
}
.prostrate_efficacy .secondary_endpointOS.Primary_endpoint .recommend .recommend_platinum{
	padding-top: 10px;
}
.profound .Primary_endpoint_chart.desktop {
    margin-bottom: 46px;
}
.monotherapy3 .Primary_endpoint_chart.desktop {
    /*margin-bottom: 20px;*/
    margin-bottom: 0px;
}
.pink78-pg-pad {
    padding-bottom: 17px;
}
p.last78-pg {
    width: 996px;
}
.hrrm-testing .biopsywrap .biopsyheading .biocontentshade .testtxt,
.hrrm-testing .biopsywrap .biopsyheading .biocontentshade .mutationstxt{
	font-size: 20px;
	top: 0;
	font-family: 'Roboto-Bold';
}
.hrrm-testing .biopsywrap .biopsyheading .biocontentshade .mutationstxt,
.hrrm-testing .biopsywrap .biopsyheading{
	transform: none;
	top: 0;
	
}

.hrrm-testing .biopsywrap .biopsyheading .biocontentshade{
	transform: none;
	padding: 2px 10px;
}
.hrrm-testing .biopsywrap .biopsyheading{
	 padding: 2px 10px;
     left: 0;           
}
.hrrm-testing .biopsywrap .subheading{
	color: #004D74;
} 
.hrrm-testing .biosywhitebg > .row{
    background: #004D7410 0% 0% no-repeat padding-box;
}   
.hrrm-testing .section-three{
	background-color: #FFFFFF;
}    
.hrrm-testing .biopsywrap .biopsycontent .border-both {
    border-left: 1px solid #004D74;
    border-right: 1px solid #004D74;
}
.hrrm-testing .biopsywrap .biopsycontent .border-bottom {
    border-bottom: 1px solid #004D74;
}

.hrrm-testing .biopsywrap .subheading{
	font-size: 20px;
}

.PROfound_wrap .robotbold18txt{
	margin-bottom: 40px;
}

p.robotbold18txt.robotbold18txtf1 {
    width: 977px;
}
.profound .profound-pros > p,
.profound .hoc-analysis{
	font-size: 20px;
    line-height: 26px;
}
        .monotherapy3 .profound-pros > p,
.monotherapy3 .hoc-analysis{
	font-size: 18px;
    line-height: 20px;
}

.Primary_endpoint_chart img{
	left: 0 !important;
}
.recommend_platinum-mobile{
    display: none;
}
.profound .container-center.skew-maroon-head{
	position: relative;
    /*left: -62px;	*/
    left: -97px;
}
.profound.efficacy .margintop50.ipadp-mtop20.paddingLeft5 ul.robotoegular20.marginleftminus20{
	margin-bottom: 0;
}
.profound.efficacy .secondary_endpointPFS{
	margin-top: 20px;
}
.profound .Primary_endpoint .container-center.skew-maroon-head{
	position: relative;
    left: -175px;
}
/*.container-center.skew-maroon-head.skew-maroon-head-wdt {
    width: fit-content!important;
    margin-left: 440px!important;
}*/
.monotherapy3 .Primary_endpoint .container-center.skew-maroon-head{
	position: relative;
    left: 30px;
}

.Primary_endpoint.section-78.sectionss-78 {
    margin: 40px auto 23px auto;
}
.hrrm-testing .prognastic .recommend{
	    padding-top: 5px;
    padding-bottom: 10px;
}
.hrrm-testing .section-navigator > a{
	font-size: 17px;
	/*padding-right: 42px;*/
    margin-right: 42px;
}
.hrrm-testing .guideline-txt-2{
	margin-bottom: 28px !important;
}
.hrrm-testing .section-two.why-test-sec {
	/*padding-top: 37px;*/
    padding-bottom: 23px;
}
.hrrm-testing .when-test h2,
.hrrm-testing .how-test h2,
.hrrm-testing .why-test h2{
	font-size: 36px;
}
.hrrm-testing .when-test h2{
	margin-bottom: 0;
}
.hrrm-testing .when-test p,
.hrrm-testing p.why-test-desc{
	/*font-size: 25px;*/
    font-size: 24px;
    line-height: 28px;
    margin: 12px auto 37px;
}
.hrrm-testing .section-three{
    /*padding-top: 30px;*/
	padding-top: 0px;
    padding-bottom: 36px;
}
.hrrm-testing .hrrm-foot-note p:first-child{
	font-size: 16px;
    text-indent: -7px;
        line-height: 20px;
}
.hrrm-testing .hrrm-foot-note p:last-child{
	font-size: 20px;
    text-indent: -7px;
    line-height: 24px;
}
.hrrm-testing .hrrm-foot-note{
	margin-top: 40px;
    padding-left: 5px;
}
.hrrm-testing .why-test{
	margin-top: 38px;
}
.hrrm-testing .mobile-only.stats-patients{
	display: none;
}
.hrrm-testing .how-test{
    margin-top: 58px;
}
.hrrm-testing .how-test h2{
	margin-bottom: 20px;
}
.hrrm-testing .flex_container_brca,
.hrrm-testing .section-two{
	background-color: #f3f7f8;
}
.hrrm-testing .section-two.how-and-when .flex_container_brca,
.hrrm-testing .section-two.how-and-when{
	background-color: #FFFFFF;
}
.hrrm-testing .middlealign{
	align-self: start;
}
.hrrm-testing p.telephone-cont{
	padding-top: 15px;
    padding-left: 18px;
    margin-bottom: 20px;    
}
.hrrm-testing  ul.listcontent.margintop20{
	padding-left: 20px;
}
.hrrm-testing .biosywhitebg .border-bottom:first-child p.telephone-cont{
	padding-left: 0;
}
.hrrm-testing .biopsywrap .biopsycontent .listcontent{
	margin-bottom: 0;
}
.hrrm-testing .biopsywrap .wheretxt{
	font-size: 20px;
    line-height: 24px;

}
.hrrm-testing .section-three .footnotecontiner .footnote {
    color: #000000 !important;
    line-height: 21px;
}
.hrrm-testing .section-one {
    background-color: #F0F0F0;
}
.hrrm-testing p.thick-txt-head{
	font-size: 20px;
    line-height: 24px;
        margin-bottom: 15px;
}
.hrrm-testing .prognastic .recommend .flex +div {
    margin-bottom: 40px;
}
.hrrm-testing .head-gudieline{
	margin-bottom: 20px;
}
.hrrm-testing .prognastic .recommend .flex{
	margin-bottom: 20px;
}

.hrrm-testing p.thick-txt-head + p{
	font-size: 20px;
    line-height: 24px;
}
.hrrm-testing .recommend_based{
	font-size: 30px;
    line-height: 34px;
}
.hrrm-testing h2.container-center {
    /*max-width: 1140px;
    margin-left: 168px;*/
}
.hrrm-testing h2.container-center span.nowrap {

    white-space: initial;
}
body.profound.safety-tolerability .pink_eyebrow,
.dosing-page .common-headline{
	padding-top: 50px !important;
	padding-bottom: 67px;
}
.dosing-fnt {    width: 1035px;}

.common-headline.solo-heading {padding-bottom: 30px !important;}
.dosing .mgmt-options-container,
.dosing .daily-dose-rec-container{
    max-width: 834px;
    margin: 0 auto 15px;
}
.dosing-page #maincontent .dosing-callouts .or p{
	margin-top: 15px;
    margin-bottom: 37px;
    font-size: 14px;
    line-height: 11px;
}
.dosing .dosing-callouts{
	padding-top: 45px;
}
.dosing .daily-dose-rec-container .dose-head p{
	padding: 5px;
}
.dosing .daily-dose-rec-container .dosage-body-flex .recomended-dose-txt{
    width: 50%;
    margin-right: 30px;
}
.recomended-dose-txt p:nth-child(2) {padding: 0px 80px !important;} 
#mg-300 {padding: 0px 36px 0 14px!important;}
.dosage-body-flex .recomended-dose-txt p:nth-child(3) {padding: 0px 56px  !important;}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic{
	width: 54%;
}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic img.desktop{
	display: inline-block !important;
}
.dosing .daily-dose-rec-container .dosage-body-flex{
	align-items: center;
    padding: 22px 10px 8px 30px;
}
.dosing .daily-dose-rec-container .dosage-body-flex .recomended-dose-txt p{
	line-height: 18px !important;
    font-size: 14px !important;
    text-align: center;
    margin-bottom: 15px;
    padding: 0 14px;
}

.dosing p.act-size-txt{
	margin-top: 20px;
        font-size: 14px !important;
    margin-left: -18px;
}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic img.desktop{
	padding-right: 12px;
}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic span{
	font-size: 20px;
    padding-right: 5px;                
}
.dosing .mgmt-options-container .dose-int-body,
.dosing .mgmt-options-container .dose-red-body{
	padding: 0 30px;
}
.dosing .mgmt-options-container .init-reduce{
	border-bottom: 1px solid #707070;
}
.dosing .mgmt-head > p{
	padding: 5px 0;
    margin-bottom: 0;
}
.dosing .mgmt-options-container > div:first-child > p{
	font-size: 25px !important;
    margin-bottom: 30px;
    margin-bottom: 20px;
    margin-top: 30px;
}
.dosing .mgmt-options-container .init-reduce, .dosing .mgmt-options-container .final-reduce,
.dosing .mgmt-options-container .mgmt-opt-flex{
	    align-items: center;
    justify-content: space-between;
}
.dosing .mgmt-options-container .mgmt-opt-flex p{
	text-align: center;
}
.dosing .mgmt-options-container .dose-red-body p,
.dosing .mgmt-options-container .dose-int-body p{
	font-size: 14px !important;

}
.dosing .mgmt-options-container .dose-int-body p{
	line-height: 18px !important;
    /*padding: 20px 40px 54px 40px; */
    padding: 20px 70px 54px 70px;
}
.dosing .mgmt-options-container .init-reduce p >span.reduce-txt-span,
.dosing .mgmt-options-container .final-reduce p>span.reduce-txt-span {
	font-size: 12.5px;
}
.dosing .mgmt-options-container .mgmt-opt-flex p.init-dose-txt ,
.dosing .mgmt-options-container .mgmt-opt-flex p.final-dose-txt{
	font-size: 12px !important;
    line-height: 16px !important;
    max-width: 232px;
}
.dosing span.upcase{
	white-space: nowrap;
}
.dosing .dose-interrupts{
	 max-width: 255px;
        width: 100%;
}
.dosing .dose-reduces{
	max-width: 563px;
        width: 100%;
}
.dosing .mgmt-options-container .dose-int-body img.desktop {
    margin: 0 auto;
    padding: 50px 10px 0;
}
.dosing .mgmt-options-container .init-reduce, 
.dosing .mgmt-options-container .final-reduce{
	    padding: 10px 0 18px;
}

.dosing .mgmt-options-container .init-reduce p:first-child, 
.dosing .mgmt-options-container .final-reduce p:first-child {
    text-align: right !important;
}
.dosing .mgmt-options-container .or-connect{
	background: #D5E2EA;
	padding: 8px 15px;
   margin: 35px -20px 0 -20px;
    transform: skewX(170deg);
    border: 2px solid #FFFFFF
}
.dosing .mgmt-options-container .or-connect span{
    transform: skewX(10deg);
    display: inline-block;
}
.dosing .mgmt-options-container .dose-red-body > p:first-child{
	padding-top: 10px;
}
.dosing .mgmt-options-container .dose-int-body{
	padding: 5px 0;
}
.dosing .dosing-callouts .or p{
	font-size: 14px;
}
.dosing  .dose-discontinuation{
	max-width: 834px;
    margin: 0 auto;
}
.dosing  .dose-discontinuation-body img.desktop{
	max-width: 785px;
	width: 100%;
	margin: 0 auto;
}
.dosing-page #maincontent .dose-discontinuation h2{
	margin-bottom: 35px;
    margin-top: 5px;
}
.dosing-page #maincontent .dose-discontinuation .dose-discontinuation-body p{
	font-size: 14px;
    line-height: 18px;
    /*padding: 0 50px 0 0; */
    padding: 0px 160px 0 0;
}
.dosing .dosing-end-tag{
	max-width: 1004px;
	margin: 36px auto 0;
    padding: 13px 0;
}
.dosing .dosing-end-tag p{
	font-size: 20px !important;
    text-align: center;
}
.dosing p.init-dose-txt.desktop {
    padding: 0 10px;
}
.patient-profiles .joe .pat-detail img.desktop{
    max-width: 248px;
}
.patient-profiles .patient-profile-wrap{
	background-color: #004D7410;
    overflow: auto;
    padding: 57px;
}
.patient-profiles .pat-detail .curr-age,
.patient-profiles .pat-detail h4{
	font-size: 25px;
        margin-bottom: 23px;
}
.patient-profiles .pat-detail .curr-age{
	margin-top: 22px;
    line-height: 30px;            
}
.patient-profiles .medical-hist{
	margin-top: 20px;
    overflow: hidden;
} 
.container-center.skew-maroon-head.skew-maroon-head-wdt {
    left: -127px!important;
}
.container-center.skew-maroon-head.skew-maroon-head-wdt.skew-maroon-head-wdt-h2 { left: -120px!important;}
.patient-profiles .joe-history,
.patient-profiles .william-history{
	height: 570px;
}
.patient-profiles .med-facts{
	margin-bottom: 20px;
    font-size: 20px;
        line-height: 24px;
} 
.med-facts ul li {
	margin-bottom : 10px;
}
.width500 {width : 500px;}
.patient-profiles p.fact-head{
        font-size: 20px;
    line-height: 24px;
    position: relative;
    top: -5px;
}
.patient-profiles .joe-history, 
.patient-profiles .william-history{
	    padding: 2px 48px 0 12px;
}
.patient-profiles .end-banner-patient{
	margin-top: 37px;
}
.patient-profiles .end-banner-patient .col-xs-12.col-sm-6.joe-pot .joe-opt,
.patient-profiles .end-banner-patient .col-xs-12.col-sm-6.william-pot .william-opt{
	max-width: 493px;
    transform: skewX(170deg);
    width: 96%;
}
.patient-profiles .end-banner-patient p{
	font-size: 25px;
    line-height: 30px;
    padding: 5px 42px;
    text-align: center;
        transform: skewX(10deg);
}
.patient-profiles .med-facts p {
    padding: 0 10px 0 55px;
    text-indent: -16px;
    margin-bottom: 5px !important;
}
.hrrm-testing h2.container-center sup,
.dosing-page #maincontent h1 sup,
.treatment-paradigm .pink_eyebrow h2 sup,
.patient-profiles  h2.container-center sup{
	font-size: 16px;	
}
.hrrm-testing .guideline-txt-2 p.thick-txt-head+p{
	    line-height: 20px;
    font-size: 16px;
}
.safety-tolerability .clinicalstudytxt{
	margin-top: 41px !important;
}
.patient-profiles .magenta_eyebrow{
	padding-top: 38px;
	padding-bottom: 53px;
}
}










/*************BODY Mobile********************/
@media (max-width: 991px){
body.resource-library #maincontent,
body.treatment-paradigm #maincontent,
body.profound.safety-tolerability #maincontent{
	/*margin-top: 91px !important;*/
}
.profound .paddingLeft5{
	padding-left: 0 !important;
    margin-top: 0px !important;
}
ul.sec66-rpfs.sec66-rpfs-new .first-li::marker, ul.sec66-rpfs.sec66-rpfs-new .second-li::marker {
    font-size: 12px!important;
    color: #333333!important;
        margin-left: 3px;
}

ul.sec66-rpfs.sec66-rpfs-new li {
    padding-left: 5px;
}
span.text-indent111 {
    text-indent: 1px!important;
    display: block;
}
p.Primary_endpoint-text-blue31 {
    padding-top: 5px!important;
}
.sec661 {
    padding-left: 8px;
    /* padding-top: 20px; */
    text-indent: -6px;
}
/*#maincontent .container-center {
    padding-left: 15px;
}*/

.PROfound_wrap img.patientPopulation_A {
    padding-top: 0 !important;
}
.section-two.how-and-when .recommendImg img {
    /*width: 100px;*/
    width: 61px;
}		
		

		
.section-two.how-and-when h2 {
    font-size: 28px;
}		
	


.section-two.how-and-when p	{
    font-size: 21px;
    line-height: 26px;
}
		
.section-two.how-and-when .recommendImg {
   /* margin-right: 15px;*/
     margin-right: 26px;
}		
		
.hrrm-testing .section-two{
   /* margin: 40px 0;*/
	padding-bottom: 0;
}		

.profound.efficacy .PROfound_wrap.mobile .container-center{
	padding-left: 18px;
}
.resource-library #maincontent .container-center{
	padding-left: 0 !important;
    margin-bottom: 26px;
}
.prostrate_efficacy .magenta_eyebrow p{
	font-size: 12px !important;
	line-height: 12px !important;
}
.prostrate_efficacy .magenta_eyebrow h2{
	font-size: 20px;
	line-height: 24px;
    padding-top: 30px;
}
.profound .section-navigator > a{
	font-size: 14px;
	text-align: left;
	font-family: 'Roboto-Regular';
	color: #000000;
    /*text-decoration: underline;   */
    border-bottom: 1px solid #000000;
    display: block;     
    padding: 0;        
}
.profound .profound-pros > p,
.profound .hoc-analysis{
	font-size: 14px;
}
.prostrate_efficacy .magenta_eyebrow {
    padding-top: 25px !important;
    padding-bottom: 25px !important;        
}
.profound .section-navigator > a {
    font-size: 16px;
    line-height: 24px;
    margin-bottom: 25px;
    width: fit-content;
}
.profound .section-navigator > a:hover{
	text-decoration: none;
}
p.recommend_based-mob.mob-layout {
    font-size: 20px;
    line-height: 26px;
    text-align: center;
    margin-left: -16px;
}
.PROfound_wrap.mobile h2{
    display: none;
}
p.robotoegularb20.margintop30.first-list > span:first-child, p.robotoegularb20.margintop30.second-list {
    /*font-size: 12px !important;*/
    font-size: 16px !important;
}
p.robotoegularb20.margintop30.first-list span.body-endpoint > span{
	color: #58595B;
    /*font-size: 12px !important;*/
    font-size: 16px !important;
    font-family: 'Roboto-Bold';            
}
p.robotoegularb20.margintop30.first-list span.body-endpoint{
	color: #58595B;
    font-family: 'Roboto-Regular'; 
    /*font-size: 12px !important;*/
    font-size: 16px;            
}    
.bullentcontent ul.robotoegular20.marginleftminus20{
	color: #58595B;
}        
.bullentcontent ul.robotoegular20.marginleftminus20 li > span{
	font-family: 'Roboto-Bold';
}
h3.centerAlign.robotoegularb20.margintop35{
	font-size: 20px !important;
    line-height: 26px;
    text-align: center;
}
.PROfound_wrap .robotbold18txt{
	font-size: 18px !important;
    line-height: 20px !important;
}
.PROfound_wrap.mobile p.footnote{
	font-size: 10px !important;
    color: #000000 !important;
    margin-bottom: 25px;
    line-height: 12px !important;
}
.profound .Primary_endpoint .container-center h2, 
.profound .secondary_endpoint .container-center h2{
	margin: 0;
    padding: 0 10px;
    font-size: 16px !important;
}
.profound .container-center.skew-maroon-head {
    width: 94% !important;
    margin-left: -10px;
    padding: 13px 10px;
}
/*.container-center.skew-maroon-head.section31 .section311s {
    width: 95% !important;
}*/
.container-center.skew-maroon-head.pink78.pink78-new {
    margin-left: 112px!important;
}
.profound .Primary_endpoint .container-center h2{
	padding-right: 55px;
    padding-left: 20px;
}
.profound .secondary_endpoint .container-center h2{
	padding-left: 20px;
}
h2.select-sec {
    line-height: 20px!important;
}
.secondary_endpointOS p.recommend_based {
    font-size: 16px !important;
} 
.recommend_platinum.first_rec_platin p.recommend_based {
    font-size: 14px; 
}
p.recommend_based.recommend_based-fnt {
    font-size: 20px!important;
    line-height: 26px!important;
}
p.recommend_based.font-size {
    font-size: 20px!important;
        line-height: 26px!important;
}
.profound .secondary_endpoint .recommend .recommend_based, 
.profound .secondary_endpointPFS .recommend .recommend_based,
#objective_response_rate .mobileLeftAlign{
	/*font-size: 14px !important;*/
    /*line-height: 18px;*/
}
.profound p.footnote.m-graytxt {
    font-size: 12px !important;
    line-height: 14px !important;
    color: #58595B;
}
.profound p.robotoegular20, 
.profound .ipadp-mtop20 ul.robotoegular20.marginleftminus20 {
    font-size: 15px !important;
    line-height: 18px !important;
}
.profound p.robotoegular20, 
.profound .robotoegular ul.robotoegular20.marginleftminus20 {
    font-size: 18px !important;
    line-height: 20px !important;
}
#objective_response_rate.secondary_endpoint .recommend_platinum{
        padding: 2% 0px 2% 30px!important;
}
.recommend_platinum-mobile p{
    font-family: 'Roboto-Bold' !important;
	transform: skewX(10deg);
	padding: 0 0px 0 24px;
    margin-bottom: 20px;
}
.secondary_endpointPFS .recommend{
	left: 25px !important;
}
.profound .orr-a, .profound .orr-ab {
    margin-bottom: 20px;
    /*padding: 14px 10px 14px 6px;*/
    padding: 14px 7px 14px 6px;
}
.profound .orr-a h2, 
.profound .orr-ab h2{
	font-size: 18px;
    margin: 0;
    padding: 0 0 0 2%;
}
.sk-new {
    transform: skewX(5deg)!important;
}
h2.sk-new {
    margin-left: 1%!important;
}
p.cohort-foot.sk-new.sk-new-padding-left {
    padding-left: 29px!important;
}
.profound .orr-a p.cohort-txt, 
.profound .orr-ab p.cohort-txt{
	/*font-size: 14px !important;
    line-height: 16px;
    padding: 0 10px 0 4%;
    margin-top: 6px;*/
     font-size: 16px !important;
    line-height: 20px;
    padding: 0 10px 0 6%;
    margin-top: 6px;
}
.sk-new-l {
    padding-left: 4px!important;
}
    p.cohort-txt.sk-new.sk-new-ll {
    padding-left: 16px!important;
}
  p.cohort-foot.sk-new.sk-new-l1 {
    padding-left: 25px!important;
}
 p.cohort-foot.sk-new.sk-new-l2 {
    padding-left: 32px!important;
}
    p.pad-left.ittp-font {
    font-size: 20px!important;
    }
.profound .orr-a p.cohort-foot, 
.profound .orr-ab p.cohort-foot{
	/*font-size: 10px !important;
    line-height: 10px;
    padding: 0 0px 0 28px;
    margin-top: 10px;*/
        font-size: 12px !important;
    line-height: 14px;
    padding: 0 0px 0 46px;
    margin-top: 10px;
}
.profound .cohort-container{
	width: 92%;
    margin: 0 auto 0 20px;
}
.cohort-container.cohort-container12.cohort-container12n {
    width: 87%!important;
}
.cohort-container.cohort-container2.cohort-container2n {
width: 87%!important;
}
.profound .orr-ab p.cohort-foot:last-child {
    padding-left: 54px;
    line-height: 14x !important;
}
.orr-ab p.cohort-txt:nth-child(3) {
    padding-left: 32px;
}

.orr-ab p.cohort-foot:nth-child(4){
    padding: 0 0px 0 45px;

}
.profound .mobileLeftAlign{
	text-align: center !important;
        font-size: 16px !important;
}
.secondary_endpointPFS h3.centerAlign.mobileLeftAlign.robotoegularb20{
	padding: 10px 0px 0px;
}
.secondary_endpointOS.Primary_endpoint.prospectivess-new {
    padding: 5px 0 0px 0!important;
}
p.recommend_based.font-retro-20 {
    font-size: 20px!important;
    line-height: 26px!important;
}
.secondary_endpointOS.Primary_endpoint .recommend{
	-webkit-transform: none;	
    left: 0 !important;
}
    .profound-pros-16{
    font-size: 16px!important;
    line-height: 20px!important;
            /*padding: 0 13px!important;*/
}
.profound .Primary_endpoint.secondary_endpointOS .recommend .recommend_based {
    transform: skewX(5deg);
        padding-left: 3px;
}   
.profound .Primary_endpoint.secondary_endpointOS .recommend .recommend_platinum {
		padding-bottom: 0;
}
.profound .secondary_endpoint img{
		padding-left: 0;
}
.recommend_platinum.first_rec_platin{
	padding: 0 10px 0 !important;
}
.secondary_endpoint .recommend{
	    overflow: visible !important;
}
.profound .profound-pros > p{
	padding: 0 20px;
}
.secondary_endpointOS.Primary_endpoint .mobile{
	display: flex !important;
    justify-content: center;
    align-items: baseline;
}
.secondary_endpointOS.Primary_endpoint .mobile img{
	width: 90%;
    padding-left: 0;
    margin-bottom: 30px;
}
.PROfound_wrap .toggleWrap img{
	max-width: 390px;
	width: 390px;
	margin-left: -57px;
}
.hrrm-testing  .biopsywrap .mobile .basedtxt{
	margin-left: 0;
}
.hrrm-testing .pink_eyebrow h2{
	font-size: 24px;
}
.hrrm-testing .pink_eyebrow{
	padding-top: 55px;
}
.hrrm-testing .section-navigator {
	    padding-top: 32px;
}
.hrrm-testing .section-navigator > a{
	font-size: 16px;
    display: block;
        margin-bottom: 25px;
    width: fit-content;
}
.hrrm-testing .head-gudieline h2,
.hrrm-testing .when-test h2,
.hrrm-testing .how-test h2,
.hrrm-testing .why-test h2{
	font-size: 24px;
}
.hrrm-testing .when-test p,
.hrrm-testing p.why-test-desc{
	font-size: 20px;
        line-height: 24px;
}
.hrrm-testing .pat-mcrpc{
	background-color: #801852;
    margin-left: -35px;
         padding: 10px 10px 10px 35px;
    transform: skewX(170deg);
    width: 103%;
    max-width: 600px;
    margin-top: 30px;
}
.hrrm-testing .pat-mcrpc h2,
.hrrm-testing .pat-mcrpc p{
	color: #FFFFFF !important;
    transform: none;
}
.recommend_platinum.recommend_platinum-top {
    padding-bottom: 24px;
}
.hrrm-testing .pat-mcrpc h2{
	font-family: 'Roboto-Bold';
    font-size: 20px;
        margin-bottom: 0;
    margin-top: 5px;
}
.hrrm-testing .pat-mcrpc p{
	font-family: 'Roboto-Regular';
	    font-size: 16px;
    line-height: 20px;
}
.hrrm-testing .pat-mcrpc h2 span{
	font-size: 33px;
}
.hrrm-testing .mcrpc-inner{
	transform: skewX(10deg);
}
.hrrm-testing .pat-mcrpc-table {
    color: #004D74;
    font-size: 16px;
    font-family: 'Roboto-Bold';
    margin-top: 20px;
}
.hrrm-testing .statusfield{
	display: flex;
	justify-content: space-between;
    padding: 5px 10px;
}
.hrrm-testing .hrrm-foot-note{
	margin-top: 20px;
        padding: 0 10px;
}
.hrrm-testing .statusfield:nth-child(odd){
	background-color: #FFFFFF;
}
.hrrm-testing .hrrm-foot-note p:first-child{
	    font-size: 14px;
    line-height: 16px;
}
.hrrm-testing .hrrm-foot-note p:last-child{
	    font-size: 16px;
    line-height: 18px;
}
.hrrm-testing .flex_container_brca{
	text-align: left;
	width: 98% !important;
    padding-top: 30px;
}
.hrrm-testing .how-test .mobile img,
.hrrm-testing .when-test .mobile img{
	width: 100%;
}
.hrrm-testing .when-test{
	margin-bottom: 35px;
}
.hrrm-testing .how-test{
    margin-bottom: 20px;
}
.hrrm-testing .when-test .mobile,
.hrrm-testing .how-test .mobile{
	display: flex !important;
	justify-content: center;
}
.hrrm-testing .section-two.why-test-sec .flex_container_brca,
.hrrm-testing .section-two.why-test-sec {
    background-color: #f3f7f8;
}
.hrrm-testing .biopsywrap .subheading{
	font-size: 18px;
}

p.subheading {
    font-size: 15px!important;
    line-height:13px!important;
}
p.subheadingtwo.Mutations-de {
    font-size: 15px!important;
    line-height: 13px!important;
}

.hrrm-testing .biopsywrap .contentwrap .subheadingtwo +p,
.hrrm-testing .biopsywrap .contentwrap .subheadingtwo{
	color: #000000;
}
.hrrm-testing .col-xs-12.col-sm-6.ctdna-test p.subheadingtwo,
.hrrm-testing .col-xs-12.col-sm-6.ctdna-test p.subheadingtwo + p{
	color: #004D74;
}
.hrrm-testing .biopsywrap .basedtxt,
.hrrm-testing .biopsywrap .contentwrap ul.listcontent,
.hrrm-testing .col-xs-12.col-sm-6 p.subheadingtwo + p{
	font-size: 14px !important;
    line-height: 18px;
}
.Mutations-sub {
    font-size: 14px !important;
    line-height: 18px!important;
}
    p.subheadingtwo.Mutations-de {
    font-size: 15px!important;
    line-height: 13px!important;
}
.hrrm-testing p.telephone-cont{
	clear: both;
    /*font-size: 18px;
    line-height: 24px;*/
font-size: 14px;
    line-height: 18px;
    letter-spacing: 0.5px;
    padding-right: 71px;
}
h1.dosing-fnt {
    font-size: 24px !important;
    line-height: 30px !important;
}


.hrrm-testing .biopsywrap .wheretxt{
	font-size: 18px;
    line-height: 24px;
}

.hrrm-testing .section-three .footnotecontiner .footnote{
	font-size: 14px !important;
}
.hrrm-testing .section-three .footnotecontiner .footnote.footnote-nw {
    font-size: 16px !important;
    line-height: 20px!important;
}
.hrrm-testing .section-one {
    background-color: #FFFFFF;
}
.hrrm-testing .prognastic .recommend .recommend_based{
	font-size: 20px;
    line-height: 22px;
    margin-left: 10px;
}
.hrrm-testing .prognastic .recommend{
	padding-left: 18px;
    padding-right: 18px;
}
.hrrm-testing .head-gudieline{
	margin-bottom: 20px;
}
.hrrm-testing .prognastic .recommend .flex{
	margin-bottom: 15px;
} 
.hrrm-testing .prognastic .recommendImg img{
	max-width: 80px;
}        
.hrrm-testing .guideline-txt-1{
	margin-bottom: 50px;
}
.hrrm-testing p.thick-txt-head + p{
	font-size: 14px;
        line-height: 16px;            
}
.hrrm-testing p.thick-txt-head{
 	line-height: 20px;
}
/*.recommend.container-center{
	padding-left: 20px !important;
} */  
.dosing-page #maincontent .dose-discontinuation .dose-discontinuation-body p{
	font-size: 14px;
}
p.most-para {
    font-size: 16px!important;
    line-height: 20px!important;
}
.dosing-page #maincontent p.act-size-txt{
	padding: 0 5px;
    margin-left: -27px;
}
.dosing .daily-dose-rec-container .dose-head{
	margin-bottom: 3px;
}
.dosing .daily-dose-rec-container .dose-head p{
	font-size: 18px !important;
    padding: 10px 0;            
}
.dosing .daily-dose-rec-container .dosage-body-flex{
	flex-direction: column;
    padding: 10px 15px 10px 15px;
}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic img.mobile {
    max-width :55px;
    padding: 0 5px;
}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic img:nth-child(2){
 	max-width :80px;
}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic{
	margin: 0 auto;
}
.dosing p.act-size-txt{
	margin-top: 20px;
}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic span{
	font-size: 14px;
}
.dosing .mgmt-options-container .mgmt-opt-flex{
	flex-direction: column;
}
.dosing .mgmt-options-container > div:first-child p{
	font-size: 20px !important;
    line-height: 22px !important;
}
.dosing .mgmt-options-container > div:first-child{
	margin: 25px auto;
}
.dosing .mgmt-head > p{
	    font-size: 18px !important;
    padding: 10px 0;
    margin-bottom: 2px;
}
.dosing .mgmt-options-container .dose-red-body p, 
.dosing .mgmt-options-container .dose-int-body p{
	font-size: 18px !important;
}
.dosing span.upcase {
    white-space: nowrap;
    font-size: 14px;
}
.dosing .mgmt-options-container .init-reduce p >span.reduce-txt-span, 
.dosing .mgmt-options-container .final-reduce p>span.reduce-txt-span{
	font-size: 14px !important;
    position: relative;
    right: -20px;
}
.dosing .mgmt-options-container .dose-int-body{
	text-align: center;
    padding: 10px 10px;                        
} 
.dosing .mgmt-options-container .dose-int-body p{
	padding: 14px 0 10px;
    line-height: 20px !important;
} 
.dosing .mgmt-options-container .dose-red-body > p:first-child{
	text-align: center;
    line-height: 20px !important;
}

.dosing .mgmt-options-container p.final-dose-txt.mobile, 
.dosing .mgmt-options-container p.init-dose-txt.mobile{
	font-size: 14px !important;
}
.dosing .mgmt-options-container .or-connect{
	padding: 15px 0;
    text-align: center;
        margin-top: -25px;
}
.dosing .mgmt-options-container .or-connect span{
	background-color: #FFFFFF;
    padding: 0 20px;
}
.dosing .mgmt-options-container .init-reduce, 
.dosing .mgmt-options-container .final-reduce{
	justify-content: center;
    align-items: flex-start;
    padding: 16px 0;
}
.dosing .mgmt-options-container .dose-red-body{
	    padding: 5px 10px 15px;
}
.dosing .mgmt-options-container .init-reduce p, 
.dosing .mgmt-options-container .final-reduce p{
	text-align: right !important;
    line-height: 24px !important;
}
.dosing .mgmt-options-container .init-reduce img.mobile, 
.dosing .mgmt-options-container .final-reduce img.mobile{
    max-width: 90px;
    margin-left: 10px;
}
.dosing .mobile.for-border{
    border-top: 2px solid #707070;
    max-width: 230px;
    width: 100%;
    position: relative;
    display: block !important;
    margin: 10px auto;

}
.dosing-page #maincontent .dose-discontinuation .dose-discontinuation-body p{
	margin-bottom: 20px;
}
.dosing .dosing-end-tag p{
    font-size: 16px !important;
    line-height: 18px !important;
}
.dosing .dosing-end-tag{
	padding: 14px 10px 14px 20px;
    margin-left: -5px;
        width: 98%;
}
.dosing .dosing-callouts{
	padding-top: 28px !important;
}
.dosing .mobile.border-for-or{
	border: 1px solid #707070;
    width: 60%;
    margin: 30px auto 0;
}
.dosing .container-center.inner-wrapper.full-width-wrapper{
	width: 100%;
    margin: 0;
    padding: 0 !important;
}
.dosing-page #maincontent .dose-discontinuation h2,
.dosing-page .img-blue-backgnd + p{
	padding-left: 15px;
    padding-right: 12px;
}
.dosing-page .img-blue-backgnd{
    background: #EAF3FA;
}
.dosing-page #maincontent .dose-discontinuation h2{
	margin-top: 0 !important;
        font-size: 18px !important;
}
.dosing-page .img-blue-backgnd img{
	margin: 25px;
}
.dosing .dosing-callouts .or {
    padding: 0 15px;
}
.safety-tolerability .platinum_chart.mobile img{
	width: 325px!important;
}
.patient-profiles .pat-detail h4{
	    font-size: 18px;
        margin-bottom: 20px;
}
.joe img.mobile{
	max-width: 243px;
}
.wiliam img.mobile{
	max-width: 290px;
}
.patient-profiles p.curr-age{
    font-size: 18px;
}
.patient-profiles .pat-detail .curr-age br{
	display: none;
}
.patient-profiles .joe,
.patient-profiles .wiliam{
	padding: 0;
}
.patient-profiles .pat-detail .curr-age{
    margin-left: 145px;
    margin-top: -30px;
}
.patient-profiles .mobile.joe-history, 
.patient-profiles .mobile.william-history{
	margin-top: 15px;
}
.patient-profiles .patient-profile-wrap{
	margin-top: 20px;
}
.patient-profiles .william-opt,
.patient-profiles .joe-opt{
	background-color: #B2D234;
    transform: skewX(170deg);
    margin-top: 20px;
}
.patient-profiles .william-opt p,
.patient-profiles .joe-opt p{
	color: #004D74;
	font-family: 'Roboto-Bold';
	font-size: 18px;
        margin: 0;
    transform: skewX(10deg);
    line-height: 22px;
    padding: 8px 20px 8px 14px;
}
.patient-profiles .mobile.col-xs-12.col-sm-6.joe-pot
.patient-profiles .mobile.col-xs-12.col-sm-6.william-pot {
    width: 350px;
}
.patient-profiles .wiliam.col-xs-12.col-sm-6 {
    margin-top: 40px;
}
.patient-profiles p.fact-head::before{
	left: -13px;
    top: 0px;
}
.patient-profiles .joe-history, 
.patient-profiles .william-history{
	padding: 0 12px 0 10px;
}
.patient-profiles .med-facts ul{
	padding-left: 10px;
}
.patient-profiles .med-facts {
    padding: 0 14px;
}    
.patient-profiles p.fact-head{
	margin-bottom: 5px;
    margin-left: -5px; 
    position: relative;
    top: -4px;
}    
.patient-profiles .med-facts li{
	line-height: 22px;
}
.patient-profiles .mobile.col-xs-12.col-sm-6.joe-pot,
.patient-profiles .mobile.col-xs-12.col-sm-6.william-pot{
	 padding-left: 0;
}
.patient-profiles #maincontent{
	margin-top: 90px !important;
}
.patient-profiles .magenta_eyebrow{
	padding-top: 30px;	
}
.patient-profiles .magenta_eyebrow p.container-center{
    line-height: 22px;
	    margin-bottom: 15px;
}
.patient-profiles .med-facts ul ~p{
	text-indent: -12px;
    padding: 0 0 0 22px;
}
.patient-profiles #maincontent .container-center {
    padding: 0 20px;
}
.profound .hoc-analysis li > span {
    position: relative;
    left: -3px;
}
ul.hoc-analysis.hoc-analysis-li li::marker{

}


}







/*************ipad BODY****************/
@media (min-width: 768px) and (max-width: 992px){
.recommend_platinum-mobile p{
	transform: none !important;
}	
.profound .container-center.skew-maroon-head{
	width: fit-content !important;
}	
.hrrm-testing .how-test .mobile img,
.hrrm-testing .when-test .mobile img{
	width: 60%;
}
.patient-profiles .joe.col-xs-12.col-sm-6,
.patient-profiles .mobile.joe-history.col-xs-12.col-sm-6,
.patient-profiles .mobile.col-xs-12.col-sm-6.joe-pot,

.patient-profiles .wiliam.col-xs-12.col-sm-6,
.patient-profiles .mobile.william-history.col-xs-12.col-sm-6,
.patient-profiles .mobile.col-xs-12.col-sm-6.william-pot{
	width: 100%;
}
}


/***fluidic****/
@media (min-width: 768px) and (max-width: 1003px){
#maincontent{
	margin-top: 90px !important;		
}
.hrrm-testing .flex_container_brca{
	padding-left: 20px !important;
}

.profound .orr-a p.cohort-foot:last-child { padding-left: 36px;}
.orr-ab p.cohort-txt:nth-child(3) {padding-left: 36px;}
.orr-ab p.cohort-foot:nth-child(4) {padding-left: 44px}
.profound .orr-ab p.cohort-foot:last-child {padding-left: 50px;}
}

 @media only screen and (min-width: 320px) and (max-width: 412px) {
.profound .orr-a h2, .profound .orr-ab h2{
	margin-left: -3%;
}	
    h2.sk-new {
    margin-left: 1px!important;
}
            h2.sk-new.sk-new-left {
    margin-left: -9px!important;
}
 }

@media (min-width: 993px) and (max-width: 1024px){
.desktop {
    display: block !important;
}
}        

@media (min-width: 1024px) and (max-width: 1250px){
.hrrm-testing h2.container-center{
	margin: 0 auto;
}
.patient-profiles .medical-hist{
	padding: 30px;
}
.profound .section-navigator > a {
    font-size: 16px;
}
}

@media (max-width: 1023px) {
.home .landing-hero-image{
	background-position: center !important;
}

}

@media (min-width: 1024px) {
.home .landing-hero-image{
	background-image: url(/content/dam/physician-services/us/590-lynparza-hcp-branded/hcp-prostrate/desktop/prostate-cancer-banner.jpg);
}

}
@media (min-width: 768px) and (max-width: 1023px) and (orientation: portrait){
.dosing-page #maincontent {
    margin-top: 95px !important;
}
}


/****IE******/
@media all and (-ms-high-contrast: none), (-ms-high-contrast: active) {
.profound .Primary_endpoint .container-center.skew-maroon-head {
    position: relative;
    left: 0px;
}
.profound .container-center.skew-maroon-head{
	left: 0;
}                                
}            

@media (min-width: 320px) and (max-width: 374px){
.dosing-page #maincontent p.act-size-txt{
	margin-left: 0;
}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic img.mobile{
	max-width: 46px;	
}
.dosing .daily-dose-rec-container .dosage-body-flex .dosage-graphic img:nth-child(2) {
    max-width: 70px;
}   
.secondary_endpointPFS .recommend .recommend_based-mob {
    padding-right: 20px;
}
.PROfound_wrap .toggleWrap img{
	width: 300px;
}
img.patientPopulation_A {
    width: 349px!important;
}
.isi-tray.mobile-isi-tray.open-state.isi-tray-show{
	padding-bottom: 20px;
}
.treatment-paradigm .platinum_chart img{
	    margin-left: -10px;
}
p.recommend_based-mob.mob-layout {
    font-size: 20px;
    line-height: 26px;
    text-align: center;
    margin-left: -10px;
}
.cohort-container.cohort-container12.cohort-container12n {
     width: 95%!important; 
}
.cohort-container.cohort-container2.cohort-container2n {
    width: 95%!important; 
}
.profound .cohort-container.cohort-container12 {
    margin-left: 19px;
}
.profound .cohort-container.cohort-container2 {
    margin-left: 14px!important;
}
}                            

@media (min-width: 992px) and (max-width: 1023px){
.home .recommendImg img{
	    padding-right: 23px;
    padding-left: 10px;
}
.hrrm-testing .biopsywrap .biopsycontent .biosywhitebg{
	padding: 0;
} 
.hrrm-testing h2.container-center{
	margin-left: 10px;
}        
}

@media (min-width: 961px) and (max-width: 1003px){
.fullheader ul.list-inline li:nth-child(4)> a{
	width: 180px;
}

}    


@media (min-width: 993px) and (max-width: 1023px){
.profound #objective_response_rate img.desktop.img-responsive,
.profound .Primary_endpoint_chart.desktop > img {
    max-width: 90%;
}
}

@media (min-width: 1004px) and (max-width: 1024px){
.dosing-page .common-headline{
	padding-top: 93px !important;
}
}

@media (min-width: 414px) and (max-width: 476px){
.isi-mobile-only .isi-tray .isi-tray-content h2.see-imp{
	margin-bottom: 0px;
}
.PROfound_wrap .toggleWrap img{
	margin-left: -107px;
}                
}    

@media (max-width: 767px){
    .profound .cohort-container {
    	transform: skewX(175deg);
        margin: 0 0px 0 19px;
}
    #cohort-container .cohort-container:nth-child(2){
		transform: skewX(178deg);
    }
}