/* ********* common styles starts */

.black-color {
    color: black !important;
}

.dark-green-color {
    color: #7F9C21 !important;
}

.margin_8 {
    margin-top: 8px !important;
    margin-bottom: 8px !important;
}

.esmo-mbottom_12 {
    margin-bottom: 12px !important;
}

.esmo-mbottom_30 {
    margin-bottom: 30px !important;
}

.esmo-graph-data>.skew-8 {
    max-width: fit-content;
    padding: 6px 20px 8px;
    background-color: #F7FAEB;
}

.esmo-graph-data {
    display: flex;
    justify-content: center;
    margin: 16px 0 16px;
}

.esmo-graph-data .content {
    display: flex;
    gap: 9.5px;
}

#maincontent .esmo-graph-data .content .percentage {
    font-size: 33px;
    line-height: 39px !important;
}

.esmo-graph-data .content p {
    margin: 0;
}

#maincontent .esmo-graph-data .content .desc p {
    font-size: 19px;
    line-height: 22px !important;
    font-family: 'Roboto-Bold', sans-serif !important;
}

#maincontent .esmo-graph-data .content .desc p.number {
    font-size: 16px;
}

.esmo-graph-data .content .desc {
    padding-top: 7px;
}

.esmo-graph-data .content .desc p:last-child {
    padding-top: 5px;
}

.rich-text:has(.in-page-sec-menus) {
    top: 140px;
}

.esmo-italic-gap {
    margin-right: 3px;
}

.esmo-h3 {
    font-size: 28px !important;
    line-height: 33px !important;
    font-family: Roboto-bold;
    color: #004D74;
    margin: 0;
}

/* ********* common styles ends */

/* ********** Home page starts **************** */

.home-esmo2 .oc-home-banner-esmo .home-eff-cta.esmo-p2 {
    flex-direction: column;
    gap: 8px;
    max-width: 100%;
    padding: 6px 0 16px;
    margin: 0 auto;
}

.home-esmo2 .oc-home-banner-esmo .home-eff-cta.esmo-p2 a {
    background: transparent;
    border: none;
    max-width: unset;
    color: white;
    text-decoration: underline;
    padding: 0;
    display: inline;
    font-size: 18px;
    line-height: 21.6px;
    width: auto;
}

.home-esmo2 .oc-home-banner-esmo .home-eff-cta.esmo-p2 a:after {
    display: none;
}

.home-esmo2 .oc-home-banner-esmo .hero-banner-container .section-endnote {
    padding-bottom: 15px;
}

.home-esmo2 .oc-home-banner-esmo .home-eff-cta.esmo-p2 a:hover {
    text-decoration: none;
}

.home-esmo2 .oc-home-banner-esmo .hero-banner-container .esmo-home-green-section .not-real-patient p {
    color: white;
}

.home-esmo2 .home-monotherapy .home-eff-cta+a {
    margin: 16px 0 0 11px;
    display: inline-block;
    color: #7F9C21 !important;
    font-size: 16px;
    line-height: 19.2px;
}

.home-esmo2 .image-section .not-real-patients {
    bottom: 7px;
}

.home-esmo2 .prescribed-parpi-section {
    max-width: 1004px;
    margin: 0 auto;
}

.home-esmo2 .prescribed-parpi-section .img-section {
    background: linear-gradient(89.67deg, #003D62 0.31%, #006699 30.14%, #006699 69.92%, #003D62 99.75%);
    text-align: center;
    padding: 13px 0 9px;
    margin: 16px 0;
}

.home-esmo2 .oc-home-banner-esmo .hero-banner-container {
    background-size: contain;
}

.oc-home-banner-esmo .home-data-content .home-eff-cta {
    display: inline-block;
    margin: 0;
}

.oc-home-banner-esmo .home-data-content .home-eff-cta a {
    padding: 14px 20px 14px 24px;
    text-decoration: underline;
}

.oc-home-banner-esmo .home-data-content .home-eff-cta a:hover {
    text-decoration: none;
}

.home-esmo2 p.esmo-footnote {
    font-size: 14px !important;
    line-height: 16.8px !important;
}

/* ********** Home page ends **************** */
/* **************Paola-1 page starts************* */
.paola-1-esmo2 #hrd-testing {
    scroll-margin-top: 175px;
}

.subgroup-data p.subgrp-text {
    font-family: 'Roboto-Regular' !important;
}

.subgroup-data p.subgrp-text .fw-bold {
    font-family: 'Roboto-Bold';
}
.subgroup-data p.subgrp-text span.fw-bold {
    font-weight: normal;
}
.paola-1-esmo2 #pfs .esmo-graph-data {
    margin: 12px 0 0;
}

.paola-1-esmo2 #os .esmo-graph-data {
    margin: 40px 0 0;
}

.paola-1-esmo2 .esmo-graph-img.paola-67-img {
    margin: 20px auto 11px;
}

/* **************Paola-1 page ends************* */
/* **************solo-1 page starts************* */

.solo-1-esmo2 #maincontent .esmo-graph-data p {
    color: #004D74;
}

.solo-1-esmo2 #maincontent .esmo-graph-data p.number {
    font-size: 16px;
    line-height: 19.2px;
}

.solo-1-esmo2 #study-design {
    max-width: 1024px;
    margin: 0 auto;
}

.solo-1-esmo2 #maincontent #study-design p {
    margin: 0;
}

.solo-1-esmo2 #study-design .image-section {
    margin: 32px 0;
}

.solo-1-esmo2 #study-design .esmo-end-nav-sec.esmo-max-width.solo1-testing-link {
    margin: auto 20px auto auto;
}

.solo-1-esmo2 #maincontent .orr-top-content .esmo-head-flag-sec p {
    font-family: 'Roboto-Bold';
}

.solo-1-esmo2 .orr-lynp-container .orr-lynp .orr-mid-grid {
    border: 1px solid #B2D234;
}

/* **************solo-1 page ends************* */

/* ****** Dosing starts ************ */

.dosing-comb-esmo2 .body-foot li {
    font-size: 13px !important;
    line-height: 15.6px !important;
}

.dosing-comb-esmo2 .yellow-container {
    background-color: #F7FAEB;
    margin: 40px 0;
}

.dosing-comb-esmo2 .yellow-container .flex-container {
    max-width: 1004px;
    margin: 0 auto;
    display: flex;
    gap: 16px;
    padding: 32px 0;
}

.dosing-comb-esmo2 #maincontent .yellow-container .flex-container p {
    margin: 0;
    font-family: 'Roboto-Bold';
    color: #004D74;
    font-size: 19px;
    line-height: 22.5px;
}

.dosing-comb-esmo2 #maincontent .yellow-container .flex-container ul {
    padding-left: 30px;
    margin: 0;
}

.dosing-comb-esmo2 #maincontent .yellow-container .flex-container ul li:before {
    content: "";
    width: 4px;
    height: 4px;
    display: inline-block;
    border-radius: 50%;
    background-color: black;
    position: relative;
    margin-left: -15px;
    margin-right: 10px;
}

.dosing-comb-esmo2 #maincontent .yellow-container .flex-container ul li {
    list-style: none;
    position: relative;
}

.dosing-comb-esmo2 .yellow-container .flex-container>div {
    max-width: 496px;
    width: 100%;
}

.dosing-comb-esmo2 .container-center.new-median p.bold-blackhead.esmo-mbottom_0 {
    padding: 0;
}

.dosing-comb-esmo2 .dosing-callouts img {
    padding-bottom: 15px;
}

.dosing-comb-esmo2 .combi-rec-dose.container-center+.orange-content {
    margin: 40px auto 0;
}

.dosing-comb-esmo2 .neww-table.dosing-c-tab+ul.blue-list {
    padding-left: 50px;
}

.dosing-comb-esmo2 #maincontent .blue-3+ul>li {
    margin-bottom: 0;
}

.dosing-comb-esmo2 #maincontent .blue-3+ul>li.sub-list {
    padding-left: 38px;
    margin-top: 5px;
}

.dosing-comb-esmo2 .esmo-max-width.esmo-end-nav-sec {
    margin: 30px 0 40px;
}

.dosing-comb-esmo2 #maincontent h2,
.dosing-comb-esmo2 #maincontent h2 {
    margin-bottom: 20px;
}

.dosing-comb-esmo2 .orange-content .orange-inner {
    font-size: 19px;
    line-height: 22px;
}

.dosing-comb-esmo2 #maincontent h2 {
    font-size: 25px !important;
    line-height: 32px !important;
}

.dosing-comb-esmo2 #maincontent .container-center.inner-wrapper h2 {
    font-size: 28px !important;
    line-height: 33px !important;
}

/* ****** Dosing ends ************ */

body.resource-library.video-library.esmo-body #videos .grid.section {
    margin-top: 40px;
}

body.esmo-body.video-library-esmo2:has(#videos.active) .videos-page-only p.footnote.oc-foot {
    display: block;
    font-size: 13px !important;
    line-height: 16px !important;
    padding: 0;
    margin-bottom: 16px;
}

body.esmo-body.video-library-esmo2:has(#videos.active) .videos-page-only {
    display: block;
}

body.esmo-body.video-library-esmo2 .videos-page-only {
    display: none;
}

body.esmo-body.video-library-esmo2:has(#videos.active) p.footnote.oc-foot {
    display: none;
    padding: 0;
}

@media screen and (min-width : 1004px) {

    /* ********** Home page starts **************** */

    .home-esmo2 .oc-home-banner-esmo .bg-gradient {
        background: radial-gradient(37.43% 1032.07% at 50% 30.83%, #00464E 25.05%, rgba(12, 79, 57, 0) 100%);
    }

    .home-esmo2 .prescribed-parpi-section .img-section+.content {
        margin-left: -2px;
    }

    /* ********** Home page ends **************** */

    /* **************Paola-1 page starts************* */

    .paola-1-esmo2 #study-ref>.esmo-head-flag-sec {
        margin-bottom: 30px !important;
    }

    .paola-1-esmo2 .oc-end-nav-button.paola-1-testing-link {
        position: relative;
        margin-bottom: -60px;
        margin-top: 20px;
        height: 60px;
        z-index: 1;
    }

    /* **************Paola-1 page ends************* */
    /* ********* solo-1 page starts ************ */

    .solo-1-esmo2 #study-design .esmo-head-flag-sec {
        margin-bottom: 40px !important;
    }

    .solo-1.solo-1-esmo2 #study-design {
        scroll-margin-top: 60px;
    }

    /* ********* solo-1 page ends ************ */

    /* ********* Dosing page starts ********** */

    .dosing-comb-esmo2 #maincontent {
        margin-top: 129px !important;
    }

    /* ********* Dosing page ends ********** */
    body.resource-library.video-library.esmo-body div#desc3 .desc {
        padding: 6px 40px 16px 0;
    }
}


@media screen and (min-width: 1004px) and (max-width: 1100px) {
    .rich-text:has(.in-page-sec-menus) {
        top: 140px;
    }

    .home-esmo2 .oc-home-banner-esmo .banner-section-esmo .banner-1-content {
        padding-top: 10px;
    }

    .home-esmo2 .image-section .not-real-patients {
        bottom: 0;
    }

    .home-monotherapy .image-section {
        padding-bottom: 30px;
    }

    .home-monotherapy .image-section img {
        bottom: -30px;
    }

    .oc-home-banner-esmo .hero-banner-container .section-endnote p {
        padding-bottom: 20px;
    }

    /* ************** Solo-1 page starts **************** */

    .solo-1-esmo2 #study-design+div {
        padding: 0 30px;
    }

    .solo-1-esmo2.solo-1 .solo1-testing-link .oc-end-nav-button a:after {
        position: absolute;
        right: 15px;
        top: 50%;
        transform: translateY(-50%);
    }

    /* ************** Solo-1 page ends **************** */

    /* ************* Dosing starts ************ */

    .dosing-comb-esmo2 #maincontent .container-center.new-median,
    .dosing-comb-esmo2 #maincontent .container-center.inner-wrapper,
    .dosing-comb-esmo2 #maincontent .yellow-container,
    .dosing-comb-esmo2 #maincontent .combi-rec-dose.container-center,
    .dosing-comb-esmo2 #maincontent .access-anemia.container-center {
        padding-left: 30px !important;
        padding-right: 30px !important;
    }

    .dosing-comb-esmo2 #maincontent .orange-content.container-center {
        max-width: 92%;
    }

    .dosing-comb-esmo2 #maincontent .container-center.inner-wrapper {
        padding-left: 10px !important;
        /* max-width: 1064px; */
        padding-right: 10px !important;
    }

    .grid.section {
        /* padding: 0 30px; */
        /* max-width: 1024px; */
        /* margin: 0 auto; */
    }

    /* ************* Dosing ends ************ */
}

@media screen and (min-width :1004px) and (max-width : 1024px) {
    .dosing-comb-esmo2 #maincontent .dosage.doubled-ORR>.inner-wrapper {
        padding: 30px 10px 20px !important;
    }

}

@media screen and (min-width : 400px) and (max-width:991px) {
    .video-library-esmo2.global-redesign .isi div#approvUse {
        margin-top: 40px !important;
        padding-top: 0 !important;
    }
}

@media screen and (min-width:768px) and (max-width: 1024px) {
    .video-library-esmo2 .video-frame iframe {
        height: 410px;
        width: 500px;
    }

    body.resource-library.video-library.esmo-body div#desc3 .desc {
        padding-left: 20px;
        padding-right: 10px;
    }

    body.resource-library.video-library.esmo-body.video-library-esmo2 .video-callouts>div {
        max-width: unset;
        padding: 0;
    }

    .video-library-esmo2 .video-callouts {
        padding: 0;
        max-width: 97%;
    }

    .video-library-esmo2 .desc {
        padding-top: 0;
        padding-bottom: 0;
    }

    .video-library-esmo2 .thumbnail .thumb-head h2 {
        height: 55px;
    }

    body.resource-library.video-library.esmo-body .video-frame {
        max-width: unset !important;
    }

    .container-center.clearfix.video-callouts {
        display: flex;
    }

    .container-center.clearfix.video-callouts .col-xs-12.col-sm-4:last-child {
        width: auto;
    }

}

@media screen and (max-width : 1003px) {

    /* *********** Common styles starts *********** */

    .esmo-graph-data .content .desc {
        padding: 0;
    }

    .esmo-graph-data>.skew-8 {
        padding: 16px 8px 10px 20px;
        max-width: 93%;
    }

    .esmo-graph-data .content .desc p.number {
        font-size: 16px;
    }

    .esmo-graph-data .content .desc p:last-child {
        padding: 0;
    }

    .rich-text:has(.in-page-sec-menus) {
        top: 159px;
    }

    /* *********** Common styles ends ************ */

    /* ********** Home page starts **************** */

    .home-esmo2 .oc-home-banner-esmo .home-eff-cta.esmo-p2 {
        padding: 21px 0 16px;
        gap: 16px;
    }

    .home-esmo2 .oc-home-banner-esmo .hero-banner-container .section-endnote {
        padding-bottom: 8px;
    }

    .home-esmo2 .home-monotherapy .home-eff-cta+a {
        margin-left: 0;
    }

    .home-esmo2 .prescribed-parpi-section {
        padding: 0 20px;
        margin-bottom: 20px;
    }

    .home-esmo2 .prescribed-parpi-section .img-section {
        padding: 41.7px 0;
        display: flex;
        justify-content: center;
    }

    .home-esmo2 .prescribed-parpi-section .img-section>img {
        max-width: 289px;
        width: 100%;
    }

    .home-esmo2 .prescribed-parpi-section .img-section+.content {
        padding: 0 5px;
    }

    .oc-home-banner-esmo .home-data-content .home-eff-cta a {
        font-style: italic;
    }


    /* ********** Home page ends **************** */
    .paola-1-esmo2 .oc-end-nav-button.paola-1-testing-link {
        height: 60px;
    }

    /* ********* solo-1 page starts ************ */
    .solo-1-esmo2 #maincontent #study-design {
        margin: 0 !important;
        padding: 0 20px !important;
    }

    .solo-1-esmo2 #study-design .image-section {
        margin: 16px 0;
        display: flex;
        justify-content: center;
    }

    .solo-1-esmo2 #study-design .esmo-end-nav-sec.esmo-max-width.solo1-testing-link {
        margin: 0 auto;
    }

    .solo-1-esmo2 #maincontent #study-design+div .content-inner-wrapper {
        padding-left: 20px;
        padding-right: 20px;
    }

    /* ********* solo-1 page ends ************ */

    /* ********* Dosing starts ********** */

    .dosing-comb-esmo2 .yellow-container .flex-container {
        flex-direction: column;
        gap: 22px;
        padding: 40px 20px;
    }

    .dosing-comb-esmo2 #maincontent .yellow-container .flex-container ul {
        padding: 0;
    }

    .dosing-comb-esmo2 #maincontent .yellow-container .flex-container ul li {
        padding-left: 10px;
        font-size: 16px;
        line-height: 19.2px;
        margin-bottom: 8px;
    }

    .dosing-comb-esmo2 #maincontent .yellow-container .flex-container ul li:before {
        margin: 0;
        position: absolute;
        left: 0;
        top: 6px;
        width: 3px;
        height: 3px;
    }

    .dosing-comb-esmo2 #maincontent .yellow-container .flex-container p {
        margin-bottom: 22px;
    }

    .dosing-comb-esmo2 #maincontent .yellow-container .flex-container ul li:last-child {
        margin-bottom: 0;
    }

    .dosing-comb-esmo2 .yellow-container .flex-container>div {
        max-width: 100%;
    }

    .dosing-comb-esmo2 #maincontent .container-center {
        padding-left: 20px;
        padding-right: 20px;
    }

    .dosing-comb-esmo2 .orange-content {
        transform: skewX(-10deg);
        max-width: 84%;
        border-top: none;
        border-left: 8px solid #F7931D;
        margin: 40px auto;
    }

    .dosing-comb-esmo2 .orange-content .orange-inner {
        transform: skewX(10deg);
    }

    .dosing-comb-esmo2 .median-common-ar .orange-content.container-center {
        max-width: 95%;
        margin: 53px auto 40px;
    }

    .dosing-comb-esmo2 .exclamation-icon {
        display: none;
    }

    .dosing-comb-esmo2 .site-caution {
        padding-left: 20px;
        padding-right: 20px;
    }

    .dosing-comb-esmo2 #maincontent .access-anemia.container-center {
        padding: 0;
    }

    .dosing-comb-esmo2 .access-anemia.container-center>h2,
    .dosing-comb-esmo2 .access-anemia.container-center>h2+p {
        padding: 0 20px !important;
    }

    .dosing-comb-esmo2 .access-anemia-table td.l-align[colspan="2"],
    .dosing-comb-esmo2 .access-anemia-table td.all-blue {
        padding-left: 20px;
        padding-right: 20px;
    }



    .dosing-comb-esmo2 .esmo-max-width.esmo-end-nav-sec {
        max-width: 93%;
        margin-left: auto;
        margin-right: auto;
    }

    .dosing-comb-esmo2 .oc-end-nav-button a {
        position: relative;
    }

    .dosing-comb-esmo2 .oc-end-nav-button a:after {
        position: absolute;
        right: 10px;
        top: 56%;
        transform: translateY(-50%);
    }

    .dosing-comb-esmo2 .combi-rec-dose.container-center+.orange-content {
        margin: 40px auto;
    }

    .dosing-comb-esmo2 .container-center.inner-wrapper.esmo-update {
        padding: 0 !important;
    }

    .dosing-comb-esmo2 .dosage.doubled-ORR {
        margin-top: 40px;
    }

    .dosing-comb-esmo2 .dosecallout .callout .image {
        text-align: left;
    }

    .dosing-comb-esmo2 .big-note.bulleted:before {
        padding-right: 2px;
        margin-left: 2px;
    }


    /* ********* Dosing ends ********** */

    body.resource-library.video-library.esmo-body #videos .grid.section {
        margin-top: 34px;
    }

    body.resource-library.video-library.esmo-body .video-frame {
        max-width: 354px;
    }

    body.resource-library.video-library.esmo-body .video-callouts>div {
        padding: 0;
    }

}

@media screen and (width:1024px) {
    .dosing-comb-esmo2 #maincontent .dosage.doubled-ORR>.inner-wrapper {
        padding: 30px 30px 20px !important;
    }
}

@media screen and (min-width :380px) and (max-width : 767px) {
    .dosing-comb-esmo2 .dosecallout .callout .text {
        max-width: 59%;
    }

    .combination-therapy.dosing-administration-oc .grid.section .dosingcallout .col-xs-12.col-sm-4:last-child {
        margin-bottom: 15px;
    }
}


@media screen and (max-width : 370px) {
    .dosecallout .callout .text {
        max-width: 60%;
    }

    /* *********** Home starts **************** */
    .home-esmo2 .oc-home-banner-esmo .home-data-content .home-eff-cta a {
        padding: 14px;
    }

    .home-esmo2 .home-monotherapy .card {
        padding: 12px 15px 21px;
    }

    .home-esmo2 .prescribed-parpi-section .img-section {
        padding: 41.7px 20px;
    }

    .home-esmo2 .oc-home-banner-esmo .paola1-flag img {
        width: 100%;
    }

    /* *********** Home ends **************** */

    /* ************* Dosing starts ********** */

    .dosing-comb-esmo2 .text-nowrap.break-small-screen {
        white-space: break-spaces;
    }

    /* ************* Dosing ends ********** */
}