html{
        scroll-behavior: smooth !important;
}
.oc-efficacy-solo2 .common-headline h1 sup{
	left: -4px;
}
.oc-efficacy-solo1 .new-pfs-data sup, 
.paola-1 .new-pfs-data sup, 
.paola-1 .new-os-data sup{
	    margin-left: 1px !important;
}
.paola-1 .new-pfs-data .chart-sub-head sup,
.paola-1 .new-os-data h3 sup{
	margin-left: 0px !important;
}
.eff-solo1 .patients-flex {
    display: flex;
    align-items: center;
}
.eff-solo1 .lhsSDTable img {
    width: 88px;
}
.eff-solo1 .lhsSDTable {
    margin-right: 20px;
}
.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable .studyDesignTableCell:first-child {
    margin-right: 15px;
}


.new-solo2 p.eyebrow {
    max-width: 755px;
}

.eff-paola1 .horline {
    margin: 10px 0px;
    padding: 0 0 25px 22px;
    width: 95%;
    color: #004D74;
}
.eff-paola1 .list-view {
    margin-top: 35px;
    padding-left: 0px;
    background: #EAF2FA !important;
}
.eff-paola1 .horline:first-child {
    border-top: 3px solid #004d7470;
    padding-top: 6px !important;
}
.eff-paola1 .sub-list div::before {
    content: "." !important;
    color: #004D74 !important;
    font-weight: bold;
    display: inline-block;
    width: 12px;
    margin-left: -19px;
    font-size: 30px;
    position: absolute;
    margin-top: -20px;
}
.eff-paola1 .list-view div {
    font-size: 16px;
}
.eff-paola1 .horline {
    font-family: 'Roboto-Bold';
}
.eff-paola1 .horline {
    margin: 20px 0px;
    padding: 0 0 15px 30px;
    border-bottom: 2px solid #9A9B9F!important;
}
.eff-paola1 .horline {
    margin: 5px 0px !important;
    padding: 0 0 5px 22px !important;
    width: 100% !important;
}
.eff-paola1 .sub-list {
    padding: 0 0 0 20px;
    margin-top: 5px !important;
    color: #000000;
    font-family: 'Roboto-Regular';
}



span.word-brk {
    word-break: break-word;
}
ul.home-bodylist {
    padding-left: 0;
}
 .eff-paola1 .big-note.bulleted:before{
	     padding-right: 12px;
		  font-size: 26px;
 }
 .eff-paola1 p.mpfs-list.big-note.bulleted {
    padding-left: 10px;
}
.hrd-testing h3{
	border-bottom: none !important;
	padding-left: 0 !important;
}
.hrd-testing .isi h3{
	padding-bottom: 0px !important;
	line-height: 20px !important;
}

/**/
/* Temp fix*/
/*.isi-tray{ display: none !important;}
/* Temp fix ends */



/* START - Common Styles */
.content-inner-wrapper {
	padding-top: 40px;
	padding-bottom: 40px;
}
.dosing-administration-oc #maincontent sup.font-light{font-family: "Roboto-Light" !important;}
.mobile {
    display: none;
}
.oc-efficacy-solo1 a.study-design-but {
    cursor: pointer;
}
.oc-efficacy-solo1 .pstyle {
    font-style: italic;
    position: relative;
    left: 2px;
}
.common-tagging1 a:hover {background-color:#FFA836;}
.black{
        color: #000000;
    }
/* END - Common Styles */

/* START - Efficacy SOLO-1 Styles */

/**SIT**/

.orr_ul{
    padding-top: 5px;
}
.oc-safety-tolerability-solo1 #maincontent p.blue.eyebrows{font-size:18px;}

@media (max-width: 1023px){
.eff-paola1 p.mpfs-list.big-note.bulleted{
	padding-left: 22px;
	text-indent: -12px;
}
p.description.mobile a {
    color: #FFFFFF;
}
	.PAOLA-1 #maincontent .study-design ul {
		margin-left: calc(6% - 24px);
		margin-top: 10px !important;
		padding-bottom: 10px;
	}
    .PAOLA-1 .mobile {
        display: none !important;
    }
    .PAOLA-1 .desktop {
        display: block !important;
    }
	.PAOLA-1 #maincontent .callout-block p {
		font-size:20px !important;
		line-height: 20px;
    }
	.PAOLA-1 #lab-abnormalities .desktop {
    padding-bottom: 0px!important;

	}
	.common-tagging1 .arrow-icon {
    	right:18%;
    	top: -40px!important;
    }
	.common-tagging1.small-common-tag .arrow-icon {
    	right:18%important;

    }
	.flex_container_two.container-center {
	    flex-direction: column;
	}
    .padding_fix {
        margin-bottom: 0px;
        width: 87%!important;
        padding-left: 73px!important;
    }
/*.common-tagging1.small-common-tag.monotag .arrow-icon {top:-56px!important;}*/
}
.oc-efficacy-solo1 .unprecedented-efficacy .flag-data img{
        padding: 30px 0 25px;
            }
.oc-efficacy-solo1 .flag-data .visualization{
	margin-left: 30px;
        }
.oc-efficacy-solo1 .flag-data .study{
    margin-left:30px;
    width: 28%;
            }
.oc-efficacy-solo1 .median{
                margin-top: -30px;
    margin-left: 318px;
    padding-bottom: 20px;
                    }

.oc-efficacy-solo1  #maincontent h1, .oc-efficacy-solo1 #maincontent h2, .oc-efficacy-solo1  #maincontent h3, 
.oc-efficacy-solo1  #maincontent h3, .oc-efficacy-solo1 #maincontent strong{
    font-family: "Roboto-Bold";
}
.oc-efficacy-solo1  #maincontent h1{font-size:30px;line-height:36px;}
.oc-efficacy-solo1  #maincontent h2{font-size:25px;line-height:30px;}
.oc-efficacy-solo1  #maincontent h3{font-size:20px;line-height:25px;}
.oc-efficacy-solo1  #maincontent p, .oc-efficacy-solo1 #maincontent ul{font-family: "Roboto-Regular";font-size:16px;line-height:19px;}
.oc-efficacy-solo1 #maincontent p.footnote, .oc-efficacy-solo1 #maincontent .footnote p{font-family: "Roboto-Light";font-size:14px;line-height:17px;}
/**SIT**/
.oc-efficacy-solo1 .unprecedented-efficacy,
.oc-efficacy-solo1 .bicr,
.oc-efficacy-solo1 .hoc,
.oc-efficacy-solo1 .orr-lynp-container,
.oc-efficacy-solo1 .orr-top-content {
	background-color: #e5edf0;
}
.oc-efficacy-solo1 .hoc p{
	color:#000000;
        }
.oc-efficacy-solo1 #maincontent img {
	padding: 50px 0;
	max-width: 100%;

}

.oc-efficacy-solo1 #maincontent p {
	color: #000000;
	margin-bottom: 0;
	font-size: 16px;
}

.oc-efficacy-solo1 #maincontent h2 {
	font-family: 'Roboto-Bold';
	font-size: 25px;
	margin: 0;
	color: #004D74;
}
.oc-efficacy-solo1 #maincontent h3 {
	/*font-size: 16px;*/
	margin-top: 0;
	/*font-family: 'Roboto-bold';*/
	margin-bottom: 10px;
}
.oc-efficacy-solo1 .unprecedented-efficacy .study-design-linker {
	position: relative;
	width: 100%;
}
.oc-efficacy-solo1 .unprecedented-efficacy .study-design-but.desktop {
	position: absolute;
	top: 50px;
	right: 0;
	border: #004d74 solid 3px;
	padding: 8px 27px;
	font-size: 16px;
	font-family: 'Roboto-Medium';
	transform: skewX(-10deg);
	color: #004d74;
	text-decoration: none;
}
.oc-efficacy-solo1 .unprecedented-efficacy .study-design-but.desktop:hover {
	color: #ffffff;
	background-color: #004d74;
}
.oc-efficacy-solo1 .unprecedented-efficacy .study-design-but.desktop:active {
	color: #ffffff;
	background-color: #4C829D;
	border-color: #4C829D
}
.oc-efficacy-solo1 .unprecedented-efficacy .study-design-but.desktop span {
	transform: skewX(10deg);
	display: inline-block;
}
.oc-efficacy-solo1 .footnote {
	margin-top: 15px;
}
.oc-efficacy-solo1 #study-design h2 {
	margin-bottom: 30px;
}
.oc-efficacy-solo1 #study-design p {
	color: #000000;
	margin-bottom: 10px;
}
.oc-efficacy-solo1 #study-design ul {
	padding-left: 20px;
	margin: 0;
}
.oc-efficacy-solo1 #study-design ul li {
	font-size: 16px;
	margin-bottom: 3px;
}
.oc-efficacy-solo1 #maincontent .bicr p {
	color: #000000;
	margin-bottom: 10px;
}
.oc-efficacy-solo1 .median-pf-container {
	text-align: center;
}
.oc-efficacy-solo1 .median-pf-container .median-pfs>div {
	display: inline-block;
	background-color: #a99e9c;
	transform: skewX(-10deg);
	border-left: #6d6e71 solid 10px;
}
.oc-efficacy-solo1 .median-pf-container .median-pfs>div:first-child {
	margin-right: 20px;
	background-color: #004d74;
	border-left: #b2d234 solid 10px;
}
.oc-efficacy-solo1 #maincontent .median-pf-container .median-pfs p {
	margin: 0;
	color: #ffffff;
	padding: 5px 25px;
	font-family: 'Roboto-Bold';
	transform: skewX(10deg);
	line-height:20px
}
.oc-efficacy-solo1 #maincontent .prognastic p {
	color: #000000;
}
.oc-efficacy-solo1 .orr-top-content .content-inner-wrapper {
	padding-bottom: 0;
}
.oc-efficacy-solo1 #maincontent .orr-top-content p {
	color: #000000;
}
.oc-efficacy-solo1 #maincontent .orr-top-content p.center-text {
	margin-top: 40px;
	text-align: center;
	color: #004d74;
	font-family: 'Roboto-Medium';
}
.oc-efficacy-solo1 #maincontent .orr-top-content p.center-text span {
	color: #a99e9c;
}
.oc-efficacy-solo1 #maincontent .orr-lynp-container img {
	padding: 0;
}
.oc-efficacy-solo1 #maincontent .orr-lynp-container p {
	color: #000000;
}
.oc-efficacy-solo1 .orr-lynp-container .orr-lynp {
	padding-bottom: 43px;
	text-align: center;
}
.orr-top-content.hoc-analysis .container-center {
    padding-top: 0px;
        padding-bottom: 42px;
}
.oc-efficacy-solo1 .orr-lynp-container .orr-lynp .orr-mid-grid {
	text-align: center;
	/* max-width: 300px; */
}
.oc-efficacy-solo1 .orr-lynp-container .orr-lynp .orr-mid-grid .orr-callout {
	margin-top: 20px;
	background-color: #b2d234;
	font-family: 'Roboto-Bold';
	padding: 4px 0;
	transform: skewX(-10deg);
	max-width: 90%;
	width: 100%;
	display: inline-block;
}
.oc-efficacy-solo1 #maincontent .orr-lynp-container .orr-lynp .orr-mid-grid .orr-callout p {
	color: #004d74;
	transform: skewX(10deg);
	font-family: "Roboto-Bold";
}
.oc-efficacy-solo1 .oc-efficacy-solo1-ftnote {
	padding-top: 30px;
}

/**SIt fixes**/
.indent-1,.indent-2 {display: inline-block;width: 0!important;}
.indent-1{text-indent: -6px;}
.space-remove {
    text-indent: -5px;
}
.indent-2{text-indent: -11px;}
.boldText{font-family: "Roboto-Bold";}
.italicText{font-style: italic;}

.oc-efficacy-solo1 .unprecedented-efficacy center+p, .oc-efficacy-solo1 .blackText{color:#000000!important;}
.oc-efficacy-solo1 .unprecedented-efficacy center+p+p{color:#000000!important;padding-top:5px;}
.oc-efficacy-solo1 .prognastic {padding-top: 7px;padding-bottom:7px;}
.oc-efficacy-solo1 .prognastic img{margin-top: -23px!important;margin-bottom: -21px;}
.oc-efficacy-solo1 .orr-div {padding-top: 4%;}
.oc-efficacy-solo1 .orr-block > p{width:80%;}

.oc-efficacy-solo1 .orr-top-content h3 {padding-top:5px;}
.oc-efficacy-solo1 h2.efficacy-solo { padding-top: 5px;}

.oc-efficacy-solo1 .common-headline h2{margin-bottom: -6px;margin-top: -3px;}

/***25-Nov******/
.oc-efficacy-solo1 .common-headline h1 {margin-bottom: -6px;margin-top: -3px;}
.oc-efficacy-solo1 .unprecedented-efficacy {padding-top: 8px;padding-bottom: 2px;}

.oc-efficacy-solo1 .unprecedented-efficacy img.chart1{ padding-top: 75px !important; padding-bottom: 50px !important; }
.oc-efficacy-solo1 .unprecedented-efficacy img.chart2{ 
    padding-top: 0 !important;
    padding-bottom: 20px !important;
}


.oc-efficacy-solo1 .study-design{padding-top:5px;}
.oc-efficacy-solo1 .study-design h2{padding-bottom:1px;}
.oc-efficacy-solo1 .study-design img{margin-bottom:-1px;}

.oc-efficacy-solo1 .bicr{padding-top:8px;}

.oc-efficacy-solo1 .prognastic{padding-bottom:8px!important;}

.oc-efficacy-solo1 .common-tagging{padding-top:15px;padding-bottom:21px;}

.oc-efficacy-solo1 .oc-efficacy-solo1-ftnote {padding-top:38px!important;margin-bottom:-14px;}

.oc-efficacy-solo1 .container-center.content-inner-wrapper h3{ 
	margin: 0 0 20px 0;
}
.oc-efficacy-solo1 #maincontent #study-design ul.firstList {
    margin: 0 0 20px 0;
}
.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable {
    display: flex;
    flex-direction: row;
}    
.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable .studyDesignTableCell {
    display: flex;
    width: 50%;
    padding: 0 10px 0 0;
}
.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable .studyDesignTableCell td.lhsSDTable {
    width: 27%;
}
.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable .studyDesignTableCell td.rhsSDTable {
    width: 73%;
}        
.oc-efficacy-solo1 #maincontent #study-design .subheading { font-family: "Roboto-Bold"; color: #004D74; }
.oc-efficacy-solo1 #maincontent #study-design .Randomized-container .subheading {
    color: #f7941f;
}
.oc-efficacy-solo1 #maincontent #study-design .Randomized-container {
    text-align: center;
    margin: 30px 0 50px 0;
}
.oc-efficacy-solo1 #maincontent #study-design .Randomized-container .Randomized-container-media>div{
    margin-right: 20px;
    border-left: #6d6e71 solid 10px;
    display: inline-block;
    background-color: #a99e9c;
    transform: skewX(-10deg);
    margin-top: 20px;
}
.oc-efficacy-solo1 #maincontent #study-design .Randomized-container .Randomized-container-media>div:first-child{
    background-color: #004d74;
    border-left: #b2d234 solid 10px;
}
.oc-efficacy-solo1 #maincontent #study-design .Randomized-container .Randomized-container-media>div p{
    margin: 0;
    color: #ffffff;
    padding: 5px 25px;
    font-family: 'Roboto-Bold';
    transform: skewX(10deg);
    line-height: 20px;
    width: 240px;
}
.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .Investigator-pfs {
	display: flex;
	margin: 30px 0 20px 0;
}
.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsRhs{width: 7%;}
.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsLhs{width: 93%;}
.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsRhs img {
    padding: 0;
}

.PAOLA-1 #adverse-reactions img, .PAOLA-1 #lab-abnormalities img{
	padding-bottom: 10px !important;
    margin-left: 0px !important;
}
.PAOLA-1 #adverse-reactions .blue,.PAOLA-1 #lab-abnormalities .blue{
    font-family: "Roboto-Bold";
}
.PAOLA-1 #maincontent #lab-abnormalities p:last-child{
    padding-top: 0px !important;
}
.PAOLA-1 #maincontent #lab-abnormalities .ftnote1 {
	padding-top: 30px;
}
.PAOLA-1 #maincontent #lab-abnormalities .foot-space {
	padding-top: 10px;
}
.common-tagging1{
	padding-top: 30px;
    text-align: center;
}
.common-tagging1.small-common-tag {
	padding-top: 10px;
}
.common-tagging1 a{
    display: inline-block;
	width: 86%;
    padding-top: 10px;
    padding-bottom: 10px;
    color: #ffffff;
    text-decoration: none;
    font-family: 'Roboto-Bold';
    font-size: 20px;
    line-height: 25px;
    transform: skewX(-10deg);
    background-color: #f7941f;
    border: solid 3px #f7941f;
    max-width: 100%;
}
.common-tagging1.small-common-tag a span {
	transform: skewX(10deg);
    display: inline-block;
}

.common-tagging1.small-common-tag a {
	width: 70%;
    margin-left:-40px;
}
 .common-tagging1.small-common-tag.monotag .arrow-icon {
	right:16.5%!important;
                        top:58%;
                        width:18px;
                        height:18px;
}
.common-tagging1.small-common-tag .arrow-icon {
	right:20%!important;
    top:50%;
}
.dosing-page .doubled-ORR ul{
    padding-left: 16px;
}
.dosing-administration-oc #maincontent .doubled-ORR ul.orr_ul li{font-size:18px;line-height: 22px;}
.padding_fix{
margin-bottom:0px;
    width: 76%;
    padding-left: 229px;
}
.bottom_space{
margin-bottom: 0px;
}
.space_fix,.bottom_space{

    font-size: 14px;
}
.space_fix{
    margin: 20px 0;
    }
.anemia-block-1 {
    /*padding-top: 20px;*/
}
.common-tagging1 .arrow-icon{
    content: "";
    position: absolute;
    width: 13px;
    height: 13px;
    border-top: 3px solid #ffffff;
    border-right: 3px solid #ffffff;
    right:18%;
    transform: rotate(45deg);
    top: -32px;
}

/**SIT**/
/* END - Efficacy SOLO-1 Styles */

/* START - Mobile Styles */

@media(max-width: 767px){
.combination-therapy .dosing-callouts img {
    padding-bottom: 5px !important;
}
.dosing-administration-oc #maincontent .doubled-ORR ul.orr_ul li{font-size:15px;line-height: 18px;}
	.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable.studyDesignTable1 {
        margin: 20px 0 0 0;
    }
	.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable {
        display: block;
    }
	.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable .studyDesignTableCell {
        width: 100%;
        padding: 0;
    }
	.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable .studyDesignTableCell td.lhsSDTable img {
        width: 80%;
    	margin: 27px 0;
    	padding: 0;
    }
	.oc-efficacy-solo1 #maincontent #study-design .Randomized-container .Randomized-container-media>div p {
        width: 119px;
        height: 90px;
        padding: 5px 15px;
    }
	.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsRhs {
        width: 12%;
    	margin: 0 30px 0 10px;
	}
	.oc-efficacy-solo1 #maincontent #study-design .Randomized-container-media{
        display: flex;
        max-width:300px;
        margin:0 auto;
    }
    .oc-efficacy-solo1 #maincontent #study-design .Randomized-container-media div {
        display: flex;
        width:50%;

    }
    .oc-efficacy-solo1 #maincontent #study-design .Randomized-container-media div p {
        display: flex;
        align-items: center;
    }

	.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsLhs{ width:88%; }
	.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsRhs img{ padding: 25px 0 0 0; }
	.oc-efficacy-solo1 .median-pf-container .median-pfs>div {
		margin-left: -4%;	
	}
	.oc-efficacy-solo1 .common-tagging a {
    	padding: 5px 41px;
	}
	.oc-efficacy-solo1 .common-tagging {padding-top: 0!important;}
	.oc-efficacy-solo1 #maincontent .common-page-title p {
		font-family: 'Roboto-Bold';
	}
.oc-efficacy-solo1 #maincontent .flag-data img{
        padding: 21px;
            }
.oc-efficacy-solo1 .study1{
    padding: 3px !important;
    margin-bottom: 13px;
        }
.oc-efficacy-solo1 .flag-data .visualization{
	margin-left: 0;
        }
.oc-efficacy-solo1 .median{
                margin: 0px;
}

}

@media(max-width:768px) and (min-width:700px){
	.oc-efficacy-solo1 .orr-block > p{width:85%;}
}
 /*   @media (min-width: 1024px) {
    .combination-therapy .dosing-callouts img {
    margin-bottom: -9%;
    margin-top: -8%;
     padding-bottom:0 !important;
}
        }*/
@media (max-width: 1023px) {
	/**SIT**/
 .oc-efficacy-solo1 #maincontent .unprecedented-efficacy img.chart1 { padding: 20px 0 !important;}  
	.oc-efficacy-solo1 #maincontent .unprecedented-efficacy img.chart2 { padding: 0 0 10px 0 !important;}  	
 .oc-efficacy-solo1 #maincontent p.hr-from { margin-top: 7px;}
 .oc-efficacy-solo1 #maincontent p, .oc-efficacy-solo1 #maincontent ul{font-size:13px}
 .oc-efficacy-solo1 #maincontent .study-design img { padding: 35px 0 50px 0;} 
 .oc-efficacy-solo1 #maincontent .orr-lynp-container .orr-div.one img {
		padding-top: 7px;
		padding-bottom: 7px;
	}

.oc-efficacy-solo1 .oc-efficacy-solo1-ftnote {
    padding-top: 10px;
}
	.oc-efficacy-solo1  #maincontent h1{font-size:20px;line-height:25px;}
    .oc-efficacy-solo1  #maincontent h2{font-size:18px;line-height:22px; margin-bottom:10px; }
    .oc-efficacy-solo1  #maincontent h3{font-size:15px;line-height:18px;}
    .oc-efficacy-solo1  #maincontent p, .oc-efficacy-solo1  #maincontent ul > li{font-size:13px;line-height:16px;}
    .oc-efficacy-solo1  #maincontent .footnote p, .oc-efficacy-solo1  #maincontent p.footnote {font-size:10px!important;line-height:16px;}
	/**SIT**/
	.mobile {
		display: inherit;
	}
	.desktop {
		display: none;
	}
	.oc-efficacy-solo1 .unprecedented-efficacy .study-design-but.mobile {
		margin-top: 15px;
		font-size: 18px;
		text-decoration: underline;
		color: #004d74;
		display: inline-block;
	}
	.oc-efficacy-solo1 #maincontent .prognastic .scroll-more p {
		font-size: 14px;
		font-style: italic;
		font-family: 'Roboto-Light';
		margin: 10px 0 25px 0;
	}
	.oc-efficacy-solo1 #maincontent .orr-lynp-container img {
    padding-top: 19px;
    padding-bottom: 3px;
}
	.oc-efficacy-solo1 .orr-lynp-container .orr-lynp .orr-mid-grid .orr-block {
		max-width: 350px;
	}
	.oc-efficacy-solo1 .oc-efficacy-solo1-ftnote {
		background-color: #e5edf0;
		padding-bottom: 15px;
    	margin-top: -53px;
	}
	.oc-efficacy-solo1 .median-pf-container .median-pfs>div {
		max-width: 45%;
		vertical-align: top;
	}
	.oc-efficacy-solo1 #maincontent .prognastic .image-scroll {
		width: 100%;
	}
	.oc-efficacy-solo1 #maincontent .prognastic .image-scroll .image-scroll-inner {
	    width: 835px;
    height: 330px;
	}
	/*.dosing-administration-oc #maincontent .doubled-ORR .image-scroll .image-scroll-inner {
		width: 1412px;
		height: 497px;
	}*/
	.oc-efficacy-solo1 #maincontent .prognastic .image-scroll .image-scroll-inner img {
		padding: 10px 0;
	}

	/**SIT**/
	.oc-efficacy-solo1 .prognastic img{margin-top:0px!important;}
	.oc-efficacy-solo1 #maincontent .median-pf-container .median-pfs p{padding: 2px 10px;}
	/**SIT**/
.common-tagging1.small-common-tag.monotag .arrow-icon {
    right: 19%!important;
    top: 58%!important;
}
}


@media only screen and (min-width: 1024px){
	/*.oc-efficacy-solo1 #maincontent .study-design-linker img { padding: 30px 0 50px 0;} */
	.oc-efficacy-solo1 #maincontent .study-design img { padding: 30px 0;} 
	.oc-efficacy-solo1 #maincontent .unprecedented-efficacy .study-design-but.desktop { top: 29px;}
	.oc-efficacy-solo1 #maincontent p.footnote { margin-top: 8px;    padding-bottom: 8px;}
	.oc-efficacy-solo1 #maincontent .prognastic img{ padding: 43px 0 50px 0;} 
	.oc-efficacy-solo1 .oc-efficacy-solo1-ftnote { padding-top: 22px;}
.common-tagging1 .arrow-icon {right:18%!important;}
.PAOLA-1 #maincontent #lab-abnormalities .callout-block {max-width:85%!important;}
.PAOLA-1 #maincontent #lab-abnormalities .callout-block p{font-size:22px;}
.common-tagging1.small-common-tag.monotag a {
	width: 75%;
                padding-left:30px;
                padding-right:30px;

}
.oc-efficacy-solo1 .study {
    width:25%;
    display: inline-block !important;
        }
.common-tagging1.small-common-tag.monotag {padding-top:36px;}

}

/*---------samsung tab-----------*/
@media only screen and (min-width: 800px) and (max-width: 1280px){
 .oc-efficacy-solo1 #maincontent #study-design .studyDesignTable .studyDesignTableCell td.rhsSDTable {width: 75%;padding-left: 26px;}   

}
 @media only screen and (min-width: 768px) and (max-width: 1024px) and (orientation: portrait) {
.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable .studyDesignTableCell td.rhsSDTable { padding-left: 15px;}
.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsRhs { width: 4%; margin-right: 15px;} 
        .common-tagging1.small-common-tag.monotag {padding-top:36px;}
}    
@media only screen and (min-width: 415px) and (max-width: 600px){
.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsRhs {
    width: 7%;
}
.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsRhs img {
    padding: 0;
}
        }

@media only screen and (min-width: 601px) and (max-width: 930px){
.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsRhs {
   width: 4%;
    margin-right: 12px;
}
.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsRhs img {
    padding: 0;
}
        }  
@media only screen and (min-width: 931px) and (max-width: 1023px){
.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsRhs {
   width: 2%;
    margin-right: 12px;
}
.oc-efficacy-solo1 #maincontent #study-design .Investigator-assessed .pfsRhs img {
    padding: 0;
}
        }    


    /*PAOLA Safety*/

.blue{
    color: #004D74;
}
.green{
    color: #B2D234;
}
        .PAOLA-1 #maincontent .orange{
    color: #F7931D;
}

/*.PAOLA-1 #maincontent .footnote p{
 line-height:0px !important;
}*/

/*.isi-tray{
    display:none !important;   
}
*/
.PAOLA-1 #maincontent .study-design ul {
	margin-top: 25px;
}
.PAOLA-1 #maincontent .study-design ul li {
	font-family: Roboto-Bold;
	font-size: 16px;
	color: #3F4444;
	line-height: 18px;
}
.PAOLA-1 #maincontent .study-design .footnote.extra-space {
	margin-top: 15px;
}
.PAOLA-1 #maincontent .callout-block{     
    background-color: #B2D234;
    max-width: 84%;
    margin: 30px auto;
    text-align: center;
    color: #004D74;
    font-family: 'Roboto-Bold';
    font-style: italic;
    padding: 15px;
    transform: skewX(-10deg);
}

.PAOLA-1 #maincontent #lab-abnormalities .callout-block {
	background-color: #ffe6cb;
	border-left: #f7931d solid 9px;
	max-width: 75%;
	padding: 30px 15px;
}

/*.combination-therapy.dosing-administration-oc.dosing-page .clinical-studies.doubled-ORR {
    background-color: #FFF;
} */   

.combination-therapy.dosing-administration-oc.dosing-page .doseModiPAOLA1{
    font-size: 20px;
    line-height: 25px;
    margin-top: 0;
    padding: 0;
    margin: 30px auto 15px auto;
    color: #004D74;
    font-style: italic;
    text-align: center;
    font-family: "Roboto-Bold";
    width: 70%;
}

.combination-therapy .callout-block {
    background-color: #B2D234;
    max-width: 99%;
    margin: 25px auto;
    color: #004D74;
    font-family: 'Roboto-Bold';
    font-style: italic;
    padding: 15px;
    transform: skewX(-10deg);
}

.combination-therapy .dosing-callouts .callout-block{
    padding: 1.5% 5.5% 1.5% 2.5%;
    background: #FFE6CB;
    border-left: 6px solid #F7931D;
	width: 70%;
}

.combination-therapy .clinical-studies .callout-block {
    max-width: 90%;
    text-align: center;
}

.combination-therapy .callout-block p,.combination-therapy .callout-block ul li{
    transform: skewX(10deg);
	font-family: "Roboto-Bold" !important;
}
.PAOLA-1 #maincontent .callout-block p{
    margin-bottom: 0;
    transform: skewX(10deg);
    color: #004D74;
    font-family: 'Roboto-Bold';
}
.paola-1 .blue-color, .blue{
	color: #004D74 !important;

}

/*.fullnavigation .navbar-default .navbar-nav>li.olaparib-dosing>a:after {
    border: 2px solid rgba(255,255,255,.8);
    position: absolute;
    left: 184px;
    top: 15px;
    border-bottom: none;
    border-right: none;
}
.olaparib-dosing .dropdown-menu.multi-level > li{
    left: -19px;
    position: relative;
    border-radius: 0px;
}
.olaparib-dosing .dropdown-menu.multi-level > li > a,.fullnavigation .navbar-default .navbar-nav>ul.olaparib-dosing ul li a,.fullnavigation .navbar-default .navbar-nav>li.olaparib-dosing a:hover{
    background-color: #f7941f !important;
    border: none !important;
    border-radius: 0px !important;

}*/
.flex_container_two {
    display: flex;

}
.flex_two_one, .flex_two_two, .flex_two_three {
    flex: 1;
    margin: 0 10px 20px 0;
}
.combination-therapy .dosing-callouts img, .combination-therapy .clinical-studies img{
    width:100%;
    padding-bottom: 35px;
    }
.combination-therapy .callout-block ul{
	padding-left: 24px;
}
@media (max-width: 767px) {
.mCustomScrollBox {
		position: relative;
		overflow: hidden;
		height: 100%;
		max-width: 100%;
		outline: none;
		direction: ltr;
	}

	.image-scroll .image-scroll-inner img {
		/*max-width: 100% !important;*/
		margin-bottom: -21px;
		padding: 10px 0;
	}
.mCS-dark-3.mCSB_scrollTools .mCSB_draggerRail {
		background-color: rgba(0, 0, 0, 0.1);
		height: 6px;
		margin: 5px 0;
	}
	.mCS-dark-3.mCSB_scrollTools .mCSB_dragger .mCSB_dragger_bar {
		background-color: #004D74 !important;
		opacity: 1 !important;
		width: 100%;
		height: 6px;
	}
	#adverse-reactions .image-scroll .image-scroll-inner {
		width: 1020px;
		height: 485px;
	}
	#lab-abnormalities .image-scroll .image-scroll-inner {
		width: 1019px;
		height: 545px;
	}
	.PAOLA-1 #maincontent #lab-abnormalities .callout-block {
		    padding: 13px 0px;
		margin: 15px auto 0;
		transform: skewX(-7deg);
		max-width: 95%;
        margin-bottom:20px;
	}
	.PAOLA-1 #maincontent #lab-abnormalities .callout-block p {
		transform: skewX(7deg);
	}
.flex_container_two.container-center {
    margin-bottom: 0px;
    flex-direction: column;
}
.flex_two_one, .flex_two_two, .flex_two_three {
    flex: 1;
    margin: 0 0px 20px -20px;
}
.common-tagging1.small-common-tag.monotag .arrow-icon {

   right:7%!important;
   top:36%!important;
                }
}
@media (max-width: 767px) {
    .PAOLA-1 .mobile {
        display: block !important;
    }
    .PAOLA-1 .desktop {
        display: none !important;
    }
.PAOLA-1 .study-design .blue{
    font-family: Roboto-bold !important;
     font-size: 14px!important;
        }
.PAOLA-1 .study-design .scroll-more p{
	margin:0px !important;
}
.PAOLA-1 #maincontent .callout-block{
	max-width: 100%;
}
.PAOLA-1 #maincontent .callout-block p{
     font-size: 15px !important;
}
.PAOLA-1 #lab-abnormalities .scroll-more p{
    padding-bottom: 10px;
    margin-top: 6px !important;
}
.oc-safety-tolerability-solo1 #maincontent #lab-abnormalities p:last-child{
    padding-top: 2px!important;

}
.combination-therapy .callout-block {
    margin: 0px;
}

.combination-therapy .dosing-callouts .callout-block{
    margin: 20px 0 0 20px;
    width:90%;
}


.combination-therapy.dosing-administration-oc.dosing-page .doseModiPAOLA1 {
    font-size: 18px;
    line-height: 23px;
}

.combination-therapy .clinical-studies .callout-block {
    max-width: 100%;
    text-align: center;
    margin-bottom: 30px;
}

.common-tagging1 .arrow-icon{
    right:18%;
    top: -51px !important;
    width: 18px;
    height: 18px;
    transform: rotate(38deg);

}
.common-tagging1 a {
    font-size:16px;
    width: 71%;
}
    	.PAOLA-1 #maincontent .callout-block p {
		font-size:15px !important;
    }
.common-tagging1 {
    padding-top: 10px;
    text-align: center;
    width: 90%;
	margin-top: 30px;
	color: #ffffff;
    text-decoration: none;
	transform: skewX(-10deg);
    background-color: #f7941f;
    border: solid 3px #f7941f;

}
.common-tagging1.monotag {width:95%;}
.common-tagging1 a{
	transform: skewX(+10deg);
    margin-top:-11px;
}
.padding_fix {
    margin-bottom: 0px;
    width: 87% !important;
    padding-left: 19px !important;
}
.PAOLA-1 #maincontent .study-design ul li {
	font-size: 13px;
    line-height: 16px;
}
.common-tagging1.small-common-tag a{width:84%;padding:12px 6px 12px 6px;border:0;}
.common-tagging1:hover {background-color:#FFA836;}
.combi .common-tagging1.small-common-tag .arrow-icon {right:7%!important;top:40%!important;}
.break-word{
        word-break: break-word;
    }

}
@media (max-width: 340px) {

    .common-tagging1.small-common-tag a {margin-left:-25px;padding: 12px 10px 12px 0px;}

}

/*******************ipad-portrait fixes*******************************/

@media screen and (min-device-width: 481px) and (max-device-width: 1024px) and (orientation:portrait) {

p.median {
    margin-left:200px !important;
      margin-bottom: -40px !important;
    margin-top: 0px !important;
}
.flag{
    display: block;
    margin: 0 auto;
    width: 70%;
            }
.visualization{
    display: block;
    margin: 0 auto !important;
    width: 70%;
            } 
.oc-efficacy-solo1 #maincontent img {
	    padding: 30px 0;
    }
img.study1.mobile{
margin: 0 auto;
    width:70%;
    padding-top: 45px !important;
    }
}
@media (max-width: 992px) {
	.indent-1 {
    text-indent: -5px;
}
.space-remove {
    text-indent: -4px;
}
.neww-table.sp1-table3 td, 
.neww-table.sp1-table3 th{
	padding: 4px 4px;
}
.dosing-c-tab td, 
.dosing-c-tab th{
	padding: 4px 4px !important;
}
}


@media (max-width: 1023px) {
.eff-solo1 .patients-flex {
    flex-direction: column;
}
.eff-solo1 .patients-flex p {
    font-size: 16px !important;
    line-height: 20px !important;
}
.monotherapy .recommended-dosage p,
.monotherapy .dose-interruption p{
	    top: 0% !important;
}

.monotherapy #maincontent p.pt10 {
    font-size: 16px;
    line-height: 20px;
}

.monotherapy .dose-reduction-header {
    background-color: #757575;
}

.monotherapy .dosage.doubled-ORR.patient .container-center.inner-wrapper >p{
    font-size: 16px !important;
    line-height: 20px !important;
}
.median-ar-table td{
	 line-height: 20px;
}

.monotherapy p.abbr {
    margin-top: 10px;
    margin-bottom: 30px;
}
.mono .recommended-dosage.rec-dosage {
    height: 44vh !important;
}
p.bluee-box-chart.mobile {
    font-size: 16px;
}
.paola-1 .paola-graph-func.paola-1-sec h2 {
    font-size: 16px !important;
    line-height: 20px !important;
}
.eff-paola1 .foot_note .font-light {
    font-size: 12px;
    line-height: 14px !important;
}
.paola-1-sec .bevacizumabChart {
    margin: 20px auto 18px auto !important;
}    
.paola-1 .paola-1-sec .orange-head{
    margin-bottom: 8px !important;
}
.paola-1-sec .add-os-sub{
	width: 78% !important;
}   
.add-os-sub p:last-child {
    line-height: 9px !important;
}    
.paola-study.paola-1-sec .container-center.content-inner-wrapper{
	padding-top: 0;
    padding-bottom: 10px;                    
} 
.paola-graph-func.paola-1-sec .hrdSubgroupAdditional +.container-center.content-inner-wrapper{
	padding-bottom: 15px;
}   
.paola-study.paola-1-sec .chart-sub-text {
    font-size: 20px !important;
}  
#study-ref .mpfs-box p{
	font-size: 16px !important;
}
#study-ref .hrd-box p{
	font-size: 16px !important;
	line-height: 22px !important;
}
#study-ref .box-R img + .ftnote1.footnote >p.sub_foot {
    font-family: 'MyriadPro-Bold';
}
#study-ref .imgcontent-table {
    margin-top: 18px;
} 
.paola-1 .paolacontent-cell .paolacontent-cell-2 {
    margin-top: 15px !important;
} 
#study-ref .ftnote1.footnote {
    margin-top: 10px;
}
.eff-paola1 .common-headline {
    padding: 30px 20px 20px 20px !important;
}   
.eff-paola1 div#approvUse {
    padding-top: 145px !important;
}
.patient-baseline .calloutDemographics{
	margin: 20px auto 40px !important;
}

.eff-paola1.paola-1 .paola-1-sec p.patient-head{
	font-size: 20px !important;
}

.paola-1 .paola-enrolled .content-inner-wrapper{
	padding-bottom: 5px;
}
.paola-1 .patient-baseline.paola-1-sec .content-inner-wrapper{
	padding-top: 5px;
}
.paola-1 li.horline{
	font-size: 16px !important;
}
.paola-1 .patient-baseline .hrdPositiveChartLhs .callout-blue p{
	font-size: 18px !important;
}   
.paola-1 .patient-baseline .hrdPositiveChart {
    margin: 20px 0 40px;
}
.moa .green-box {
    z-index: 0;
}
.combi .common-headline {
    padding: 30px 30px 30px 20px !important;
}
.eff-solo2 div#study-design-solo2 .content-inner-wrapper {
    padding-bottom: 10px !important;
}
.eff-solo2 .pfs-4x.paola-1-sec .content-inner-wrapper {
    padding-top: 0!important;
}
.eff-solo1 .unprecedented-efficacy.paola-1-sec .content-inner-wrapper {
    padding-top: 12px;
}

}




@media (max-width: 767px){
.mono .recommended-dosage.rec-dosage {
    margin-bottom: 50px;
}	
.eff-solo1 .lightGreen-linkbox span::after {
    /*right: -22px;*/
    right: -8px;
    margin-right: -14px;
}            
}


@media only screen and (min-width: 768px) and (max-width: 1024px) {
.dosecallout.flex_two_one .callout-text,
.dosecallout.flex_two_two p.callout-text {
    padding-left: 5px;
}
.eff-19 main#maincontent {
    margin-bottom: 40px;
}            
.mono .recommended-dosage.rec-dosage {
    margin-bottom: -40px;
}
.dosingcallout .col-xs-12:nth-child(1) {
    padding-left: 19px;
    padding-right: 19px;
}   
.dosecallout.flex_two_one .callout .image img{
	width: 105px;
}  
.dosecallout.flex_two_one .heading h3{
	letter-spacing: -0.9px;
}    
.paola-graph-func.paola-1-sec .hrdSubgroup {
    margin: 50px 0 0px !important;
}   

.dosecallout.flex_two_one .heading h3 {
    padding-left: 0;
}
}        

@media (min-width: 1024px){
.median-ar-table.desktop tr th:first-child{
	padding-left: 0;
}
.median-common-ar p.abbr {
    line-height: 14px !important;
} 
.mono .dose-reduction-header.rec-dosage-header {
    padding: 90px 44px 90px 40px;
}
}

@media only screen and (min-width: 1004px) and (max-width: 1265px){
.brca-testing .brca-test-sec .blue-call-out{
	width: 90%;
}

}

@media only screen and (min-width: 768px) and (max-width: 1023px) {
div#approvUse {
    margin-top: -70px !important;
}
}