@font-face {
    font-family: 'MyriadPro-Bold';
    src: url('fonts/myriadpro-bold.eot');
    src: url('fonts/myriadpro-bold.woff') format('woff'), url('fonts/myriadpro-bold.ttf') format('truetype');
    font-weight: normal;
    font-style: normal;
}
@font-face {
    font-family: 'MyriadPro-SemiBold';
    src: url('/etc/designs/code/physician-services/US/lynparza-hcp-branded/fonts/myriadpro-semibold.woff') format('woff');
    font-weight: normal;
    font-style: normal;
}
@font-face {
    font-family: 'MyriadPro-Regular';
    src: url('/etc/designs/code/physician-services/US/lynparza-hcp-branded/fonts/myriadpro-regular.woff') format('woff');
    font-weight: normal;
    font-style: normal;

}
sup.hard-space {
    margin-left: -3.5px;
}
.flex_two_one .image img{
	width: 136px;
}
.combi #maincontent .blue-list sup,
.combi #maincontent .dosing-callouts .body-foot sup {
    font-family: 'Roboto-Regular' !important;
}
.combi-rec-dose.container-center ul {
    list-style-type: none;
    padding-left: 0px;
}

.combi-rec-dose.container-center ul li:nth-child(2), .combi-rec-dose.container-center ul li:nth-child(3) {
    padding-left: 17px;
    text-indent: -7px;
}

.combi-rec-dose.container-center ul li.dashed-note {
    margin-bottom: 10px;
}
.isi-body p {
    color: #000000CC;
}
ul.popup-list {
    color: #000000cc;
    padding-left: 15px;    
}
#exitdialog button.btn.back:focus,
#exitdialog button.btn.ok:focus {
    outline: 5px auto -webkit-focus-ring-color !important;
}

/*******DOSING PAGE TABLES***********/
.dosing-c-tab table tr:first-child {
    border-bottom: none;
}
.monotherapy  .modifications table td{
	text-align: center;
}
.no-border th,
.no-border td{
    border: none;
    padding: 0;
}
.modifications tr:nth-child(2) td .skew-cell {
    border: none;
}
.monotherapy .modifications .table-headcell .skew-cell {
    left: 9px;
}    
.monotherapy .modifications .skew-cell{
    padding: 4px 8px;
    width: 100%;
    max-width: 100%;
    border: 1px solid #c5c5c5;
    display: block;
    transform: skewX(-10deg);
    position: relative;
    left: 3px;
}
.modifications table tr:first-child{
	border-bottom: none;
}
.modifications .skew-cell{
	background-color: #EAF2FA;
    color: #004d74;
    font-family: 'Roboto-Bold';
}
.modifications tr:nth-child(2) th {
    border: none;
}
.modifications tr:nth-child(2) td:nth-child(even) .skew-cell{
	background-color: #B2D234;
	color: #004D74;
}
.modifications tr:nth-child(2) td:nth-child(odd) .skew-cell{
	background-color: #59595B;
	color: #FFFFFF;
}
.modifications table tr:nth-child(3){
	border-top: 2px solid #006699;
}
.modifications table tr:nth-child(3) th{
	background-color: #D1E384;
	color: #004D74;
}
.modifications table tr:nth-child(4) th{
	background-color: #006699;
	color: #FFFFFF;
}
.modifications table tr:nth-child(5) th{
	background-color: #56849F;
	color: #FFFFFF;
}
.modifications table tr:nth-child(3) td:nth-child(odd),
.modifications table tr:nth-child(4) td:nth-child(odd),
.modifications table tr:nth-child(5) td:nth-child(odd){
	color: #757575;
    font-family: 'Roboto-Medium';
}
.modifications table tr:nth-child(3) td:nth-child(even),
.modifications table tr:nth-child(4) td:nth-child(even),
.modifications table tr:nth-child(5) td:nth-child(even){
    background-color: #F6F8EB;
	color: #002d74;
    font-family: 'Roboto-Medium';
}
th.row-head {
    font-size: 18px;
}
.modifications .skew-cell,
.modifications table td{
	font-family: 'MyriadPro-SemiBold' !important;
}
.median-ar-table th{
	text-align: center !important;
    padding: 0;
	width: 33.3%;
    border: none;
}
.median-ar-table .solo1-head .skew-cell{
	background-color: #D1E384;
}
.median-ar-table .solo2-head .skew-cell{
	background-color: #004D74;
    color: #FFFFFF;
}
.median-ar-table .s19-head .skew-cell{
	background-color: #56849F;
    color: #FFFFFF;
}
.median-ar-table td{
	width: 33.3%;
}
.median-ar-table .skew-cell{
    display: block;
    width: 100%;
}
td.solo1-cont {
    background-color: #F6F8EB;
}
td.solo2-cont {
    background-color: #EAF2FA;
}
td.studu19-cont {
    background-color: #F4FBFF;
}
.median-ar-table td{
    /*padding: 10px 80px 10px 10px;*/
    padding: 10px 75px 10px 10px;
    font-family: 'Roboto-Bold' !important;
    color: #525252;
    font-size: 18px;
    line-height: 24px;
    vertical-align: top;     
}
.monotherapy .median-common-ar h2.bluehead{
	font-size: 25px;
    color: #004d74;        
    line-height: 32px !important;
}
.median-ar-table .skew-cell {
    padding: 3px 5px 8px;
    transform: skewX(-8deg);
    position: relative;
    left: 3px;
}
.neww-table.safety-olympia-table.dosing-table.median-ar-table {
    margin-bottom: 0 ;
} 
.access-anemia-table{
    margin: 20px 0;
}
.access-anemia-table table tr:nth-child(1),
.access-anemia-table table tr:nth-child(7){
    border-bottom: 2px solid #56849F;
}
.access-anemia-table th,
.access-anemia-table td{
    font-family: 'Roboto-Bold';
    color: #2B2E34;
    font-size: 18px;
    line-height: 27px;
    padding: 6px 50px 6px 18px;
}
.access-anemia-table th {
    font-size: 20px;
    line-height: 28px;
}
.access-anemia-table th{ padding-right: 12px; }
.access-anemia-table tr th:first-child {
    width: 7%;
}
.all-blue {
    background-color: #F4FBFF;
    color: #004D74 !important;
}
.c-align{
    text-align: center !important;
}
.l-align{
    text-align: left !important;
}


@media only screen and (max-width: 1023px) {
.combi-rec-dose ul li {
    font-size: 16px !important;
    line-height: 20px !important;
}    
.all-break{
    word-break: break-all;
}    
.neww-table.dosing-c-tab td,
.neww-table.dosing-c-tab th {
    font-size: 16px;
    line-height: 20px;
}    
.access-anemia-table th,
.access-anemia-table td{
    font-family: 'MyriadPro-SemiBold';
    color: #2B2E34;
    font-size: 16px;
    line-height: 22px;
    padding: 6px 10px 6px 9px;
    letter-spacing: -0.16px;
}    
.access-anemia-table tr th:first-child {
    width: 30%;
}
.doubled-ORR h2.bluehead {
	margin-top: 20px !important;
}    
.median-ar-table th{
    border: 1px solid #c5c5c5;
}
.median-ar-table table tr:first-child {
    border-bottom: none;
    border-top: 2px solid #006699;    
}
.median-ar-table th{
	width: 5%;
    text-align: left !important;
    padding: 5px;
    font-family: 'MyriadPro-SemiBold';
}    
.median-ar-table td {
    padding: 10px 10px 10px 10px;
    font-family: 'MyriadPro-SemiBold' !important;
}    
.median-ar-table th.solo1-head {
    background-color: #D8E899;
}
.median-ar-table th.solo2-head {
    background-color: #004D74;
    color: #FFFFFF;
}
.median-ar-table th.s19-head {
    background-color: #55849F;
    color: #FFFFFF;
}    
.median-ar-table th.row-head {
    font-size: 13px;
    white-space: nowrap;
    font-family: 'MyriadPro-SemiBold';  
        padding: 4px 3px;        
}
.modifications  .row-head{
	padding: 4px 2px;
	font-size: 12px;
    font-family: 'MyriadPro-SemiBold';
}
.modifications .skew-cell,
.modifications table td{
	font-size: 12px;
    letter-spacing: -0.82px;
}
.modifications .skew-cell{
	padding: 4px 3px !important;
}
.modifications table tr:nth-child(3) td,
.modifications table tr:nth-child(4) td,
.modifications table tr:nth-child(5) td{
	padding: 4px 2px;
}   
span.skew-cell {
    transform: none !important;
}
.modifications .skew-cell,
.modifications .table-headcell .skew-cell {
    left: 1px !important;
    font-style: italic;
}
}
/******Tables end************/

ul.wht-capsule.wht-capsule1 {
    margin-bottom: 7px;
}
.hrd-testing ul.footnote {
    padding-left: 0;
    list-style-type: none;
}
.hrd-testing ul.footnote li {
    text-indent: -5px;
}
.eff-solo2 ul.footnote {
    padding-left: 0;
    padding-top: 20px;
    list-style-type: none;
}

.eff-solo2 ul.footnote li {
    font-family: 'Roboto-Light' !important;
    font-size: 12px !important;
    line-height: 14px !important;
    text-indent: -6px;
}
.unprecedented-efficacy ul.footnote {
    list-style-type: none;
    padding-left: 0;
}
.oc-efficacy-solo1 #study-design ul.brcaMutation-list li:nth-child(2){
	list-style-type: none;
}

.oc-efficacy-solo2 .bicr p sup {
    font-size: initial !important;
}
.rec-dosage-body img.desktop{
	margin: 0 auto;
}
.combination-therapy .callout-text {
    width: 91%;
}
.thick-font {
    font-family: 'Roboto-Bold';
}
.combination-therapy .dosecallout.flex_two_three .callout{
	margin-top: 35px;
}
.combination-therapy .dosecallout .callout {
    margin-top: 45px;
}
.combination-therapy .dosecallout .AR p.callout-heading{
	padding-right: 0;
    font-size: 16px!important;
}
.combination-therapy .callout-green {
    color: #004d74 !important;
    padding-bottom: 12px;
}
.combination-therapy  .dosecallout.flex_two_two .callout .image img{
	width: 54px;
}
.combination-therapy .callout-heading {
    color: #004d74;
    font-family: 'Roboto-Bold' !important;
    padding-right: 60px;
}
.combination-therapy .dosecallout .AR {
    margin-top: 5px;
}
.combination-therapy .dosecallout h3 {
    color: #004D74;
    padding-left: 0;
}
.combination-therapy .dosecallout.flex_two_three .heading h3::before,
.combination-therapy .dosecallout.flex_two_two .heading h3::before,
.combination-therapy .dosecallout .heading h3::before{
	content: '';
	border-radius: 0;
	height: 0;
	width: 0;
	background: none;
	padding: 0;
}
.combination-therapy  .dosing-callouts{
	background-color: #FFFFFF;
}
.combination-therapy .body-foot{
	padding-left: 0;
}
.combination-therapy .indent-1 {
    text-indent: -5px;
}
.yellow-approvals {
    background-color: #F7FAEB;
    margin: 50px 0;
}
.blue-3 {
    color: #004D74;
    margin: 10px 0;
}
.fda-lab {
    padding-top: 26px;
}
.yellow-app-container {
    padding: 50px 10px;
}
.yellow-approvals p.big-note.bulleted {
    padding-left: 12px;
}
.yellow-approvals p.dashed-note {
    max-width: 676px;
    text-indent: -9px;
    padding-left: 20px;
}
p.dashed-note {
    padding-left: 12px;
}
p.normal-copy{
    font-size: 16px !important;
    line-height: 20px !important;
}
.combi-rec-dose p{
    font-size: 16px !important;
    line-height: 20px !important;
}
.access-anemia{
    margin-top: 40px;
    margin-bottom: 40px;
}
.access-anemia h2{
    margin-bottom: 10px !important;
}
h2.bluehead{
	color: #004d74 !important;
}
.common-headline h1 {
    font-size: 30px !important;
    line-height: 36px !important;
}
.monotherapy .rec-dosage-body{
	background-color: #EAF2FA;
}
.monotherapy .dosing-callouts{
	background-color: #FFFFFF;
}
.monotherapy .dose-reduction-body {
    background-color: #E3E3E3;
    padding: 50px 25px;                
}                
.monotherapy .recommended-dosage-header h2{
	font-size: 30px !important;
	line-height: 34px !important;
}
.monotherapy .dose-reduction h2,                
.monotherapy .dose-interruption-header h2{
	font-size: 30px !important;
	line-height: 30px !important;
    width: 100% !important;                
}     
.monotherapy .dose-interruption-body a{
	color: #004D74 !important;
	font-family: 'Roboto-Bold';
}                
.monotherapy .recommended-dosage-header{
	padding: 90px 40px;
}   
.monotherapy .dose-interruption-body  {
    background-color: #F7FAEB;
}                
.monotherapy  #maincontent p.tablets-size {
    font-size: 12px;
    line-height: 14px;
    max-width: 100px;
    margin-left: 10.5%;
    margin-top: -10px;            
}

.moa-page .footnote.new.moa-foot{
	font-size: 14px !important;
    line-height: 16px !important;
    padding-left: 10px;                
}
.footnote.bannerfootnote{
	margin-top: 0;
}    
.moa-page .carousel-container h2{
    font-size: 25px;
    line-height: 32px;
    font-family: 'Roboto-Bold';
    color: #004D74;
    letter-spacing: -0.16px;
}
.moa-page p.new.thick-txt {
    font-size: 16px !important;
    line-height: 20px !important;    
}

.moa-page p.thick-txt span:first-child {
    font-family: 'Roboto-Regular';
}
.container-center.footnote-content.moa-bottom-content .footnote{
	font-size: 14px !important;
	line-height: 16px !important;
}
.green-box-container {
    margin-left: auto;
    margin-right: 0;
    width: 798px;
    overflow-x: hidden;
    margin-top: 27px;
}
.monotherapy .green-box-container{
	width: 1010px;
    margin-top: 50px;
}
.monotherapy .dosage.doubled-ORR.patient{
	padding-top: 0;
}
.subchart-head {
    font-size: 20px !important;
    line-height: 32px !important;
    margin-bottom: 0px !important;
}
.green-box {
    position: relative;
    right: -10px;
}
.green-linkbox{
    background: #E3EAC5;
    padding: 14px 0 14px 14px;
    display: block;
	border: 3px solid #B2D234;
    transform: skewX(-10deg);  
    color: #004d74;
    font-size: 20px;
    line-height: 20px;
    font-family: 'Roboto-Bold';    
}
.green-linkbox:hover{ text-decoration: none; }
.moa-page .moa-bottom-content.new {
    margin-top: 18px;
}
.green-linkbox span.green-linktxt::after{
	content:'';
	border: 4px solid #004d74;
	border-bottom: none;
	border-left: none;
	width: 14px;
	height: 14px;
	position: relative;
	right: -10px;
	top: 0px;
	display: inline-block;
	transform: rotate(42deg);
}
.moa-page .moa-bottom-content.new .footnote{
	font-size: 12px !important;
	line-height: 16px;
}
.common-headline h1 .green {
    font-size: 40px ;
    line-height: 36px ;
}
.safety-p1 #maincontent p.blue.eyebrows {
    font-size: 16px !important;
    line-height: 16px !important;
    letter-spacing: -0.2px;
    font-family: 'Roboto-Bold';
}
 .blue-org{
	font-size: 18px !important;
	line-height: 20px !important;
 }
.study-design .orange {
    color: #f6581d;
}
.big-foot p {
    font-size: 16px !important;
    line-height: 20px !important;
}
.safety-p1 .boldnote {
    font-size: 16px !important;
    line-height: 20px !important;
    font-family: 'Roboto-Bold' !important;
    text-indent: -10px;
    padding-left: 20px;

}
.safety-p1 #adverse-reactions{
	background: #FFFFFF !important;
}
.boldnote:before{
	content: "\2022";
    display: inline-block;
    font-size: 20px;
    position: relative;
    top: 2px;
    padding-right: 10px;
    color: #004D74;        
}    
.abbr p{
	font-size: 12px !important;
    line-height: 16px !important;
    font-family: 'Roboto-Light' !important;
    margin-top: 10px;    
}

.safety-p1 .ftnote1.footnote.extra-space p{
	font-size: 12px !important;
    line-height: 16px !important;
}   
.foot-space p{
	font-size: 12px !important;
    line-height: 14px !important;
    padding-bottom: 5px;
}
.long-light-blue {
    background: #EAF2FA;
    margin-top: 43px;
    margin-bottom: 25px;
}
.long-light-blue span{
	font-size: 18px;
	line-height: 24px;
	color: #004D74;
	font-family: 'Roboto-Bold';
    padding: 50px 0px;
    display: block;
    max-width: 1004px;
    margin: 0 auto;
}
.safety-p1 .callout-block{
	    max-width: 991px !important;
    width: 100% !important;
}
.oc-safety-tolerability-solo1.oc-safety-tolerability-solo1 .callout-block p{
	  font-size: 20px !important;
    line-height: 25px !important;
}
.year5-analysis.container-center {
    max-width: 835px;
        background: #EAF2FA;
    transform: skewX(-5deg);
    margin-bottom: 40px;
}
.year5-wrap {
    transform: skewX(5deg);
    padding: 10px 80px 10px;
}
.anlysis-steps li{
	padding-bottom: 5px ;
}
ul.anlysis-steps {
    padding-left: 20px;
    font-size: 16px;
    line-height: 20px;
}    
.bluehead {
    font-size: 25px;
    line-height: 26px;
}
.big-note.bulleted:before{
	content: "\2022";
    display: inline-block;
    font-size: 20px;
    position: relative;
    top: 2px;
    padding-right: 5px;
    color: #004D74;
}
.big-note{
	text-indent: -6px;
    padding-left: 18px;
    font-size: 16px;
    line-height: 20px;
    margin-bottom: 20px;
}
.body-foot{
	list-style-type: none;
    padding-left: 0px !important;
}
.body-foot li{
	font-size: 12px !important;
	line-height: 14px !important;
    font-family: 'Roboto-Light' !important;
    padding-bottom: 0;
    color: #3F4444;
}
.bold-blackhead {
    color: #000000;
    font-family: 'Roboto-Bold' !important;
    font-size: 16px;
    line-height: 20px;
    padding-bottom: 13px;
}
.dosing-page .doubled-ORR ul {
    padding-left: 0;
}
.paola-1 .abbr {
    font-size: 12px !important;
    line-height: 14px !important;
    font-family: 'Roboto-Light' !important;
    margin-bottom: 40px;
    padding-top: 10px !important;
}
.safety-p1 #adverse-reactions .abbr {
    font-size: 12px !important;
    line-height: 14px !important;
    font-family: 'Roboto-Light' !important;
    margin-bottom: 24px;
    padding-top: 0px !important;
}
.safety-p1 .content-inner-wrapper,
.safety-s1 .content-inner-wrapper,
.safety-s2 .content-inner-wrapper,
.Study-19 .content-inner-wrapper {
    padding-top: 0 !important;
    padding-bottom: 0 !important;
}
.indent-double{
	display: inline-block;
	text-indent: -10px;
}
.year-ans {
    background-color: #EAF2FA;
    max-width: 835px;
    margin: 0 auto;
    transform: skewX(-6deg);
    padding: 24px 80px;
        margin-top: 0;
}
.year-wrap {
    transform: skewX(6deg);
}

.year-wrap h2.bluehead{
	font-size: 25px;
	line-height: 32px;
    margin-left: -10px;
    margin-top: 0;
}
.year-bullets li {
    padding-bottom: 6px;
    font-size: 16px;
    line-height: 20px;
}
.safety-p1 #adverse-reactions {
    margin-top: 50px;
}
.safety-p1 .year-ans{
	margin-bottom: 24px;
}

.safety-s1 .year-ans{
    padding-top: 33px !important;
}

.oc-safety-tolerability-solo2 #maincontent #lab-abnormalities p:last-child, .oc-safety-tolerability-study19 #maincontent #lab-abnormalities p:last-child {
    padding-top: 2px !important;
}
.variable-width{
    max-width: 983px;
	width:  100%;
    margin: 0 auto;
}
.site-caution{
    padding: 25px 5px 15px 50px;
    background-color: #EAF2FA;
    transform: skewX(-7deg);
    border: 3px solid #004d74;
    margin-top: 45px;
}
.caution-inner{
	transform: skewX(7deg);
}    
.caution-inner p{
	color: #004d74;
	font-family: 'Roboto-Bold' !important;
	font-size: 20px !important;
	line-height: 25px !important;
}
.exclamtion{
    position: relative;
    z-index: 5;
}
.exclamation-icon{
	position: absolute;
    top: 50px;
    padding: 2px 26px;
    font-family: 'Roboto-Bold';
    color: #004d74;
    background-color: #FFFFFF;
    border: 3px solid #004d74;
    border-radius: 50%;
    font-size: 40px;
    left: -14px;
}
.combination-therapy .common-headline{
	padding: 38px 0;
}
.orange-content {
    margin: 50px auto;
    background-color: #FFE6CB;
    padding: 18px 18px;
    transform: skewX(-10deg);
    border-left: 8px solid #F7931D;
}
.orange-inner {
    transform: skewX(10deg);
    font-family: 'Roboto-Bold';
    color: #004d74;
    font-size: 20px;
    line-height: 25px;
}
.new-median .big-note{
	text-indent: 0;
    padding-left: 0;
	margin-top: 14px;
}
.new-median p.bold-blackhead {
    margin-bottom: 50px;
    font-size: 16px !important;
    line-height: 20px !important;
}
ul.blue-list {
    padding-left: 20px;
    margin-bottom: 14px;
}

ul.blue-list li {
    font-size: 16px !important;
    line-height: 20px !important;
}

/********-----MOBILE----************/

@media only screen and (max-width: 767px) {

   .moa-page .carousel-container h2{
    font-size: 20px;
    line-height: 24px;
    font-family: 'Roboto-Bold';
    color: #004D74;
    letter-spacing: -0.13px;
    text-align: left;
    padding-left: 10px;
} 
}


@media only screen and (max-width: 1023px) {
.paola-graph-func.paola-1-sec ul.subGroupList{
	margin-bottom: 15px !important;
}    
.combination-therapy #maincontent .access-anemia h2 {
    font-size: 18px !important;
    line-height: 22px !important;
}    
.median-common-ar .orange-content.container-center {
    margin-top: 20px;
}    
.combi .new-median p.big-note.bulleted {
    font-size: 16px !important;
    line-height: 20px !important;
    text-indent: -5px;
    padding-left: 10px;
}    
.combi a.green-linkbox {
    text-align: right;
    padding-right: 40px;
}
.combi .green-linkbox span.green-linktxt::after {
    right: -18px;
}
.combi.dosing-page .doubled-ORR{
	padding: 0;
}
.combi.dosing-page .dosing-callouts{
	padding-bottom: 0;
}
.isi-body>div>h2, .isi-body .indications h2{
	padding-top: 6px; 
}    

h2#header-isi,
.isi-body .indications > h2 {
    /*font-size: 20px;*/
    font-size: 16px;
}    
#maincontent .home-sec .oc-home-content .hero-content p{
	line-height: 14px !important;
}    
.home-sec .ocbanner-content-new {
    padding: 16px 13px !important;
}    
.home-sec .ocbanner-content-new .solo{
	left: 0 !Important;
}    
.hero-content {
    margin-top: 20px;
}
.home-sec .ocbanner-content-new{
	max-width: 100% !important;
}    
.bg-2 span.head-txt {
    width: 94%;
	    padding: 0 0px 0 13px;
}    
.top-bg-text{
	top: 10px;
}    
.combi p.abbr{
	font-size: 12px !important;
	line-height: 14px !important;
	font-family: 'Roboto-Light' !important;
    margin-bottom: 50px;  
    padding-right: 6px;
}    
.new-median p.bold-blackhead {
    margin-bottom: 20px;
}
.dosecallout .callout .image{
	text-align: right;
}    
.dosecallout .callout .text .callout-text{
	font-size: 16px !important;
    line-height: 20px !important;
}    
.eff-solo2 ul.footnote li {
    font-size: 12px !important;
    line-height: 14px !important; 
        text-indent: -5px;    
}  
.eff-solo2 ul.footnote{
    margin-top: 12px;
    padding-top: 0;    
}     
.unprecedented-efficacy ul.footnote li {
    font-size: 10px !important;
    line-height: 12px !important;
}    
.combination-therapy .flex_two_one, 
.combination-therapy .flex_two_two, 
.combination-therapy .flex_two_three{
	margin-left: -15px;
}
.combination-therapy .callout-text {
    width: 100%;
}
.combination-therapy .dosecallout .callout {
    margin-top: 20px;
}
.combination-therapy p.callout-heading {
    font-size: 16px !important;
    line-height: 20px !important;
}
.dosecallout h3 {
    font-size: 20px !important;
    line-height: 25px !important;
    margin-top: 0;
}    
.combination-therapy #maincontent h2{
	font-size: 20px !important;
	line-height: 24px !important;
}   
.orange-inner {
    font-size: 18px;
    line-height: 22px;
    transform: none;
}
.orange-content{
    transform: none;
    margin: 40px 0 35px;
    border-top: 8px solid #F7931D;
    border-left: none;
    padding: 14px 30px;
}    
.combination-therapy .green-box-container {
    position: relative;
    z-index: 1;
    margin-top: 35px;
    margin-bottom: 25px;
}
.combi-rec-dose {
    padding: 0 20px 0 20px;
}    
.blue-3 {
    font-size: 20px !important;
    line-height: 21px !important;
}
.yellow-approvals p {
    font-size: 16px !important;
    line-height: 20px !important;
}
.yellow-approvals {
    padding: 20px;
    margin: 20px 0;
}
.yellow-approvals p.big-note.bulleted {
    padding-left: 12px;
}
.container-center.yellow-app-container {
    padding: 0;
}
.fda-lab {
    padding-top: 0;
}    
.access-anemia{
    margin-top: 25px;
}
.access-anemia h2{
    margin-bottom: 15px !important;
}    
.exclamtion{
	width: 68px;
    top: -80px;    
}    
.subchart-head {
    margin-bottom: 10px !important;
}    
.subchart-head {
    font-size: 16px !important;
    line-height: 20px !important;
}
.bluehead {
    font-size: 18px;
    line-height: 22px;
    margin-top: 20px;
    padding-bottom: 20px;         
}  
.big-note{
	padding-left: 10px;
}        
.body-foot li{
	line-height: 14px;
}   
.width100 {
    width: 100%;
    max-width: 100%;
}
.year-ans.mobile .year-wrap,
.year-ans.mobile {
    transform: none;
}
.year-ans{
	padding: 33px 25px;
}

.long-light-blue span{
	padding: 20px;
}
.long-light-blue{
	margin-bottom: 10px;
	margin-top: 33px;
}
.safety-p1 #adverse-reactions {
    margin-top: 20px;
}
.paola-1.oc-safety-tolerability-solo1.safety-p1  .callout-block{
	border-left: none !important;
	border-top: 10px solid #F7931D;
    margin-bottom: 10px !important;
    margin-top: 16px !important;
}
.safety-s1 .bold-blackhead{
	padding-top: 20px;
}
.oc-safety-tolerability-solo1 #maincontent #lab-abnormalities p.abbr.mobile {
    padding: 12px 16px !important;
}
.Study-19 .content-inner-wrapper{
    padding-top: 0;
    padding-bottom: 0;
}
.safety-p1 #maincontent p.blue.eyebrows {
    font-size: 16px !important;
    letter-spacing: -0.16px;       
}   
.safety-p1 .content-inner-wrapper h2{
	font-size: 20px !important;
    line-height: 24px !important;                
}   
.safety-p1  .callout-block p,
.safety-p1 .callout-block{
	transform: none !important;
}
.outside-rep i.fa.fa-user {
    width: fit-content !important;
}
.common-headline h1{
    width: 100% !important;
}    
.common-headline {
    padding: 30px 20px 30px 20px !important;
}

.moa-page .footnote.new.moa-foot{
	font-size: 12px !important;
    line-height: 16px !important;
    padding: 0 20px 0 20px;
    margin: 15px 0 10px 0;
	left: 0 !important;
}
.oc-safety-tolerability-solo1.oc-safety-tolerability-solo1 .callout-block p {
    font-size: 18px !important;
    line-height: 22px !important;
}
.moa-page .carousel-container{
	background-color: #FFFFFF;
}                    
.moa-page .carousel-container .carousel-mobile .carousel-cont {
    background-color: #004D74;
}
.moa-page .carousel-container {
    padding: 0;
}
.moa-page .carousel-container .carousel-mobile .carousel-item img:first-child {
    width: 142px;
}
.moa-page .carousel-container .carousel-mobile .carousel-item {
    display: flex;
    align-items: center;
    padding: 0 20px;
}                
.moa-page .arrowed-border {
    width: 90%;
    border-top: 3px solid #FFFFFF;
    margin: 0 auto;
    margin-top: 10px;
} 
.v-cut {
    width: 20px;
    height: 18px;
    margin: 0 auto;
    border-right: 3px solid #FFFFFF;
    border-bottom: 3px solid #FFFFFF;
    border-radius: 2px 0 0 2px;
    transform: rotate(45deg);
    position: relative;
    top: -10px;
    background: #004D74;
} 
.moa-page .carousel-container .carousel-mobile p {
    font-family: 'Roboto-Bold';
    font-size: 18px;
    line-height: 22px;
    text-align: left;
    color: #FFFFFF;
    padding-left: 20px;
}
.container-center.footnote-content.moa-bottom-content {
    padding-top: 20px;
    padding-left: 20px;
    padding-bottom: 10px;
}
.moa-page .moa-bottom-content {
    background-color: #FFFFFF;
}
.green-box-container {
    max-width: 365px;
    margin-top: 15px;
}
.green-linkbox{
	font-size: 18px;
    padding: 8px 32px 8px 14px;
    border: 4px solid #B2D234;
}
.green-box{
	z-index: -1;
}
.green-linkbox span.green-linktxt::after{
	right: -78px;
    top: -8px;
}
#arrowfixedr::after{
    right: -5% !important;
}
.monotherapy .dose-reduction h2,
.monotherapy .dose-interruption-header h2,
.monotherapy .recommended-dosage-header h2 {
    font-size: 18px !important;
    line-height: 22px !important;
    transform: none;
}
.monotherapy .dose-reduction h2,
.monotherapy .dose-interruption-header h2{
	padding: 9px 15px!important;
    text-align: left;
}
.monotherapy .dose-reduction h2,
.monotherapy .recommended-dosage-header {
    padding: 4px 15px;
    transform: none;
    margin-bottom: 0;
    text-align: left;
}
.monotherapy .recommended-dosage-body .pt10{
	font-size: 16px;
	line-height: 20px;
}
.monotherapy #maincontent p.tablets-size {
    font-size: 9px;
    line-height: 10px;
    max-width: 80px;
    margin-left: 0%;
    margin-top: -10px;
}
.monotherapy .dose-reduction, 
.monotherapy .dose-interruption{
	margin-top: 16px;
}
.monotherapy .dose-reduction-header,
.monotherapy .dose-interruption-header{
	transform: none;
	margin-bottom: 0;
}
.monotherapy .dose-reduction p,
.monotherapy .dose-interruption-body p{
	font-size:  16px !important;
	line-height: 20px !important;
}
.monotherapy .dose-interruption-body p:nth-child(3){
	padding-top: 20px;
}
.monotherapy .dose-reduction-body {
    padding: 20px 15px 20px;
}
.monotherapy .dose-img-text-container{
	flex-direction: row;
}
.monotherapy .dose-img-text-container .dose-img{
    min-width: 80px;
    padding-right: 20px;
}        
.monotherapy .dosing-callouts{
	    padding-top: 0;
    padding-bottom: 0;
}
.monotherapy .green-box {
    z-index: 0;
}
.monotherapy .green-linkbox{
	font-size: 17px;
	line-height: 21px;
}
.monotherapy .green-linkbox span.green-linktxt::after {
    right: -63%;
    top: -20px;
    margin-left: -14px !important;
}
.monotherapy .green-box-container {
    margin-top: 20px;
}
.site-caution{
	    transform: none;
    border-left: none;
    border-right: none;
	padding: 40px 26px 15px 10px;
}
.caution-inner {
    transform: none;
}
.caution-inner p {
    color: #004d74;
    font-family: 'Roboto-Bold' !important;
    font-size: 16px !important;
    line-height: 20px !important;
}
}

.lpadding_18, .lpadding_18 ul {
	padding-bottom: 0px !important;
}
.section67-paddingBtm {
	padding-bottom: 25px !important;
}


@media only screen and (min-width: 1366px) {
.safety-s1 #lab-abnormalities h2{
    white-space: nowrap;
}

}

@media (min-width: 1024px) and (max-width: 1365px) {
.variable-width {
    max-width: 900px;
    width: 100%;
}
.exclamation-icon{
	top: 80px;
	left: 26px;
}	
}

@media (max-width: 991px){
	.safety-p1 ul.body-foot {
        padding-bottom: 40px !important;
    }

    .paola-1 .abbr p {
        line-height: 16px !important;
    }
    .safety-p1 #adverse-reactions .abbr {
        margin-bottom: 20px;
    }
	p.abbr.mobile {
        line-height: 18px;
    }
    p.abbr {
        line-height: 18px;
        margin-bottom: 20px;
    }
    .paola-1-sec .bevacizumabChart {
        margin-bottom : 0px !important;
    }
	.section67-paddingBtm {
		padding-bottom: 5px !important;
	}

} 


@media (max-width: 767px){
.combi .green-linkbox span.green-linktxt::after {
    right: -4px;
    margin-right: -14px;
}
.moa-page .common-headline h1 {
    font-size: 30px !important;
    line-height: 36px !important;
}
.exclamtion{
    left: 5%;    
}          
}
/*#arrowfixedr::after{
    right: -5% !important;
}*/
@media only screen and (max-width: 600px) {
#text-right {
   text-align: right !important;
}}

@media screen and (min-device-width: 361px) and (max-device-width: 390px) { 
    .combi .dosecallout .callout .text .callout-text {
        font-size: 15px !important;
    }
}