@font-face {
	font-family: 'MyriadPro-Bold';
	src: url('fonts/myriadpro-bold.eot');
	src: url('fonts/myriadpro-bold.woff') format('woff'), url('fonts/myriadpro-bold.ttf') format('truetype');
	font-weight: normal;
	font-style: normal;
  }
  .evidence {
  font-family: "Roboto-Bold";
	margin-bottom: 15px;
  }
  a.right.carousel-control:focus,a.left.carousel-control:focus {
	outline: 5px auto -webkit-focus-ring-color;
	outline-offset: -2px;    
  }

  .home-sec .smal-txt {
	font-family: 'Roboto-Bold';
	font-size: 11px;
	line-height: 14px;
	display: inline-block;
	color: #004d74;
	margin-bottom: 5px;
	margin-top: 3px;
  }
  
  .home-sec .norml-txt {
	font-family: 'Roboto-Bold';
	font-size: 14px;
	line-height: 16px;
	display: inline-block;
	color: #004d74;
	margin-bottom: 5px;
	margin-top: 3px;
  }
  
  .home-sec .callouts .callout p {
	transform: skewX(10deg);
	font-family: 'Roboto-Bold';
	font-size: 18px;
	line-height: 20px;
	margin: 5px 0 0 6px;
	display: inline-block;
	color: #fff;
  }
  
  .home-sec .callouts .callout span {
	transform: skewX(0deg);
	font-family: 'Roboto-Bold';
	font-size: 20px;
	line-height: 20px;
	margin: 8px 0 0 -2px;
	display: inline-block;
	color: #004d74;
	text-decoration: none;
	background: #b2d234;
	padding: 16px 10px;
	width: 278px;
	height: 50px;
  }
  
  .home-sec .ocbanner-content-new {
	/* position: absolute; */
	background-color: #004D74;
	color: #fff;
	transform: skewX(-7deg);
	padding: 25px 40px 15px;
	max-width: 99%;
	margin: 0 auto;
	margin-top: -70px;
  }
  
  .home-sec .ocbanner-content-new .paola {
	position: relative;
	left: 5px;
	transform: skewX(7deg);
	margin-top: 0;
	margin-bottom: 8px;
	font-size: 16px;
	line-height: 20px;
	font-family: 'Myriad-Pro', sans-serif;
  }
  
  .home-sec .ocbanner-content-new .solo {
	position: relative;
	left: 13px;
	transform: skewX(7deg);
	margin-top: 0;
	margin-bottom: 8px;
	font-size: 16px;
	line-height: 20px;
	font-family: 'Myriad-Pro', sans-serif;
  }
  
  .home-sec .oc-home-content .hero-content p {
	margin: 0;
	font-size: 14px;
	line-height: 18px;
  }
  
  .home-sec .oc-home-content .hero-content p.footnote {
	font-family: 'Roboto-Light';
	font-size: 12px !important;
	color: #000000;
	line-height: 20px !important;
	margin-bottom: 0;
	margin-top: 7px;
  }
  
  
  .footnote {
	font-family: 'Roboto-Light' !important;
	font-size: 12px !important;
	color: #000000 !important;
	line-height: 14px !important;
	margin-bottom: 0;
  }
  
  .paola-1-sec .heading {
	margin-bottom: 14px !important;
	display: flex;
	align-items: center;
  }
  
  .paola-1 .paola-graph-func.paola-1-sec h2 {
	margin: 0;
	font-size: 18px;
	line-height: 20px;
	font-family: Roboto-bold;
	color: #004D74;
	font-style: italic;
  }
  
  .foot_note {
	width: 100%;
	max-width: 560px;
	margin-bottom: 30px;
  }
  
  .foot_note .font-regular {
	margin: 0;
	font-size: 14px;
	line-height: 18px !important;
	margin-bottom: 10px;
	font-family: 'Roboto-Regular';
	color: #000000;
  }
  
  .foot_note .font-light {
	margin: 0;
	font-size: 12px;
	line-height: 16px;
	font-family: 'Roboto-Light';
	color: #000000;
  }
  
  .paola-1 .paola-1-sec .chart-sub-head {
	font-size: 25px !important;
	line-height: 30px !important;
	font-family: "Roboto-Bold" !important;
	color: #004D74 !important;
	font-style: normal;
	margin-top: 10px;
  }
  
  .paola-1 .paola-1-sec .chart-sub-text {
	font-size: 20px !important;
	line-height: 28px !important;
	font-family: "Roboto-Bold" !important;
	color: #004D74 !important;
	font-style: normal;
  }
  
  .paola-1-sec .study-design-link {
	position: relative;
	right: 0;
	max-width: 100%;
	display: flex;
	justify-content: flex-end;
	margin-bottom: 16px;
  }
  
  .paola-1-sec .study-design-link .study-design-but {
	border: 3px solid #004d74;
	border-radius: 100px;
	background: #E4EDC4;
	color: #004D74;
	margin: 0;
	margin-left: 10px;
	width: 245px;
	height: 50px;
	padding: 10px 10px;
	text-align: center;
	font-size: 16px;
	line-height: 18px;
	font-family: 'Roboto-Bold';
	display: flex;
	justify-content: space-evenly;
	align-items: center;
	text-decoration: none;
  }
  
  .paola-1-sec .bevacizumabChart {
	margin: 20px auto 10px auto !important;
  }
  
  p.median {
	font-size: 16px !important;
	line-height: 24px !important;
	font-family: "Roboto-Regular";
	color: #000;
  }
  
  .paola-1 p.median {
	font-size: 16px !important;
	line-height: 24px !important;
	font-family: "Roboto-Regular";
	color: #000;
  }
  
  .paola-1 .paola-graph-func.paola-1-sec {
	background-color: #FFF;
  }
  
  .paola-graph-func.paola-1-sec .hrdSubgroup {
	border: none;
	border-right: none;
	padding: 13px 20px 13px 20px;
	margin: 16px 0 10px;
	background: #F7FAEB;
  }
  
  .paola-graph-func.paola-1-sec .hrdSubgroup p {
	font-size: 16px;
	line-height: 20px;
	font-family: "Roboto-Bold";
	margin: 0;
  }
  
  .paola-graph-func.paola-1-sec .hrdSubgroupAdditional {
	padding: 50px 25px 30px;
	background: #EAF2FA;
  }
  
  .paola-graph-func.paola-1-sec .hrdSubgroupAdditional span {
	font-family: "Roboto-Bold";
  }
  
  .paola-graph-func.paola-1-sec ul.subGroupList {
	margin: 20px 0;
	padding: 0;
	list-style-type: none;
  }
  
  .paola-graph-func.paola-1-sec .hrdSubgroupAdditional p,
  .paola-graph-func.paola-1-sec .hrdSubgroupAdditional li {
	font-family: "Roboto-Regular";
	font-size: 18px;
	line-height: 22px !important;
	color: #000;
  }
  
  .paola-1 .paola-1-sec .new-pfs-data {
	margin-top: 10px;
  }
  
  .paola-1 .paola-1-sec .chart-head {
	margin-bottom: 10px !important;
	font-size: 18px !important;
	line-height: 20px !important;
	font-family: "Roboto-Bold" !important;
	color: #004D74 !important;
  
  }
  
  .paola-1 .paola-1-sec .orange-head {
	font-size: 16px;
	line-height: 22px;
	background: #F6581D;
	color: #000000;
	padding: 2px 8px;
	display: inline-block;
	transform: skewX(-10deg);
  }
  
  .paola-1 .paola-1-sec .ftnote1.footnote p {
	font-size: 14px;
	line-height: 18px;
	font-family: "Roboto-Light";
	color: #000000;
  }
  
  .mpfs-sec {
	display: flex;
	width: 100%;
	justify-content: space-between;
	margin-bottom: 10px;
  }
  .mpfs-box sup.noskew {
	display: inline-block;
	transform: skewX(10deg) !important;
  }
  
  .mpfs-box {
	background-color: #004D74;
	height: auto;
	width: 100%;
	max-width: 495px;
	padding: 13px 10px;
	color: #fff;
	transform: skewX(-10deg);
	margin-bottom: 10px;
  }
  
  .mpfs-box p {
	font-size: 18px !important;
	line-height: 22px !important;
	font-family: "Roboto-Regular";
	color: #fff;
	margin: 0;
  }
  
  .paola-1 .paola-1-sec .paolaimg-cell {
	width: 100%;
	padding: 0 !important;
  }
  
  .mpfs-sec ul {
	padding: 0;
	list-style-position: inside;
  }
  
  .mpfs-list {
	font-size: 16px;
	line-height: 18px;
	font-family: "Roboto-Regular";
	color: #333;
  }
  
  .mpfs-list span {
	position: relative;
	left: -3px;
  }
  
  ul.listpaola1asco {
	margin: 20px 0;
	padding-inline-start: 20px;
  }
  
  ul.listpaola1asco li.mpfs-list {
	font-size: 14px;
	line-height: 20px;
	text-indent: 0px;
	padding-left: 0;
  }
  
  p.paola1asco_sub_foot {
	font-size: 16px;
	color: #000;
	font-family: "Roboto-Bold";
	margin-top: 40px;
  }
  
  p.paola1asco_sub_foot.margintop0 {
	margin-top: 25px;
  }
  
  .ftnote1.footnote.select.margintop0 {
	margin-top: 0;
  }
  
  .hrd-sec {
	display: flex;
	width: 100%;
	justify-content: space-between;
	margin-top: 12px;
  }
  
  .hrd-box {
	background: #F7FAEB;
	padding: 10px;
	padding-right: 30px;
	width: 100%;
	max-width: 495px;
  }
  
  .hrd-box p {
	font-size: 18px !important;
	line-height: 22px !important;
	font-family: "Roboto-Regular";
	color: #1A1818;
  }
  
  .paola-1 .hrd-box p {
	font-size: 18px !important;
	line-height: 22px !important;
	font-family: "Roboto-Regular";
	color: #1A1818;
  }
  
  .paola-1 .paola-1-sec .ftnote1.footnote p.sub_foot {
	font-family: "Roboto-Bold";
	font-size: 16px !important;
	line-height: 20px !important;
	color: #000;
	margin-bottom: 5px !important;
  }
  
  #study-ref .ftnote1.footnote {
	margin-top: 20px;
	margin-bottom: 35px;
  }
  
  .heading h2 {
	margin: 0;
	font-size: 18px !important;
	line-height: 20px !important;
	font-family: Roboto-bold !important;
	color: #004D74 !important;
	font-style: italic;
	margin-bottom: 0 !important;
	text-align: left !important;
  }
  
  .imgcontent-table {
	margin-top: 30px;
  }
  
  .paola-1 .paola-1-sec .paolacontent-cell p,
  .paola-1 .paola-1-sec .paolacontent-cell ul li {
	font-size: 16px;
	color: #000000;
	line-height: 18px;
	font-family: "Roboto-Regular";
  }
  
  .paola-1 .paola-1-sec .paolacontent-cell .cell-head {
	color: #004D74;
	font-family: "Roboto-Bold";
	width: max-content;
  }
  
  .paola-1 .paola-1-sec ul.endpoint-list li::before {
	content: ".";
	color: #004D74;
	font-weight: bold;
	display: inline-block;
	width: 12px;
	margin-left: -15px;
	font-size: 35px;
	position: absolute;
	margin-top: -9px;
  }
  
  .paola-1 .paola-1-sec .paolacontent-cell ul li:before {
	color: #004D74;
	vertical-align: middle;
	margin-top: -9px;
  }
  
  .paola-1 .paolacontent-cell .paolacontent-cell-2 {
	margin-top: 22px;
	border: 2px solid #B2D234;
	padding: 15px;
  }
  
  .paola-1 .patient-baseline.paola-1-sec {
	background-color: #ffffff;
	margin-top: -75px;
  }
  
  .paola-1 .paola-1-sec ul.endpoint-list {
	padding-left: 15px;
	margin-bottom: 0;
  }
  
  .paola-1 .patient-baseline .hrdPositiveChartLhs p {
	font-family: 'Roboto-Regular';
	color: #000000;
	font-size: 16px;
	line-height: 20px;
  }
  
  .paola-1 .patient-baseline .hrdPositiveChart {
	margin: 40px 0;
	flex-direction: row;
  }
  
  .paola-1 .patient-baseline .hrdPositiveChartLhs {
	width: 32%;
	margin: 0;
	order: 1;
  }
  
  .paola-1 .patient-baseline .hrdPositiveChartRhs {
	width: 32%;
	order: 2;
	margin: 0 22px;
  }
  
  .paola-1 .patient-baseline .hrd-table {
	width: 33%;
	order: 3;
  }
  
  .callout-blue {
	background: #EAF2FA;
	padding: 15px 6px;
	padding-right: 30px;
	transform: skewX(-10deg);
	margin-bottom: 10px;
	margin-left: 8px;
	position: relative;
  }
  
  .paola-1 .patient-baseline .hrdPositiveChartLhs .callout-blue p {
	font-family: 'Roboto-Bold';
	color: #004D74;
	font-size: 16px;
	line-height: 20px;
	margin: 0;
	position: relative;
	z-index: 999;
	transform: skewX(10deg);
	font-style: italic;
  }
  
  .left-cover {
	background: #eaf2fa;
	width: 20px;
	height: 100%;
	position: absolute;
	top: 0;
	left: -10px;
	transform: skewX(10deg);
	z-index: 1;
  }
  
  .hrd-table table {
	background: #fff;
  }
  
  .hrd-table table th,
  .hrd-table table td {
	text-align: center;
	border: 1px solid #888;
	padding: 2px 8px;
	font-size: 16px;
	line-height: 24px;
	font-family: "Roboto-Bold";
	color: #131313;
	font-style: normal;
  }
  
  .hrd-table table th:first-child {
	width: 40%;
	background: #004D74;
	color: #fff;
  }
  
  .hrd-table table th:last-child {
	width: 60%;
	background: #B2D234;
	color: #004D74;
  }
  
  .hrd-table table th:last-child span {
	display: block;
	font-family: 'Roboto-Light';
	font-size: 14px;
	line-height: 18px;
  }
  
  .paola-1 .patient-baseline .ftnote1.footnote {
	width: 100% !important;
	margin: 5px auto 4px auto;
	max-width: 100%;
  }
  
  .paola-1 .patient-baseline .ftnote1.footnote p:last-child {
	margin-top: 0 !important;
  }
  
  .paola-1 ul.endpoint-list li {
	list-style: none;
	font-family: "Roboto-Regular";
	font-size: 16px;
	line-height: 20px;
  }
  
  .paola-1 ul.endpoint-list li strong {
	font-family: "Roboto-Bold";
  }
  
  .hrd-table table td img {
	max-width: 24px;
  }
  
  .paola-1 .paola-1-sec p.patient-enrolled {
	font-size: 20px !important;
	line-height: 28px;
	margin-bottom: 25px !important;
	margin-top: 5px !important;
  }
  
  .paola-1 .paola-1-sec .patient-head {
	font-size: 25px !important;
	line-height: 30px !important;
	font-family: "Roboto-Bold";
	color: #004D74;
  }
  
  .paola-1 .paola-1-sec .key-criteria {
	margin-left: 0 !important;
  }
  
  .paola-1 li.horline {
	margin: 10px 0px;
	padding: 0 0 25px 22px;
	width: 95%;
	color: #004D74;
  }
  
  .paola-1 .list-view li::before {
	content: " " !important;
	color: #333333;
	font-weight: bold;
	display: inline-block;
	width: 16px;
	margin-left: -20px;
	font-size: 13px;
	position: absolute;
	display: none;
  }
  
  .paola-1 ul.sub-list li::before {
	content: "." !important;
	color: #004D74 !important;
	font-weight: bold;
	display: inline-block;
	width: 12px;
	margin-left: -19px;
	font-size: 30px;
	position: absolute;
	margin-top: -9px;
  }
  
  .paola-1 ul.sub-list {
	padding: 0 0 0 20px;
	margin-top: 5px !important;
	color: #333;
  }
  
  .paola-1 li.horline {
	margin: 5px 0px !important;
	padding: 0 0 5px 22px !important;
	width: 100% !important;
  }
  
  .paola-1 li.horline {
	margin: 20px 0px;
	padding: 0 0 15px 30px;
	border-bottom: 1px solid #333 !important;
  }
  
  .paola-1 li.horline:first-child {
	border-top: 3px solid #004d7470;
	padding-top: 6px !important;
  }
  
  .paola-1 li.horline:last-child {
	border-bottom: 0 !important;
  }
  .long-light-blue sup.normal-text{
  font-style: normal;
  }
  .paola-1 ul.list-view {
	margin-top: 35px;
	padding-left: 0px;
	background: #EAF2FA !important;
  }
  
  .paola-1 ul.list-view {
	margin-top: 20px !important;
	padding-left: 0px;
  }
  
  .patient-baseline.paola-1-sec .calloutDemographics p {
	color: #004D74;
	font-family: 'Roboto-Bold';
	font-size: 20px !important;
	line-height: 25px !important;
  }
  
  .patient-baseline .calloutDemographics {
	width: 100% !important;
	height: 85px;
	display: flex;
	align-items: center;
	margin-bottom: 0 !important;
  }
  
  .patient-baseline .calloutDemographics {
	background: #FFE6CB;
	border-left: 8px solid #F7931D !important;
	width: 80%;
	margin: 40px auto;
	text-align: left;
	transform: skewX(-10deg);
	padding: 1.5% 5.5% 1.5% 2.5%;
  }
  
  .paola-1 .ftnote1.footnote p {
	font-size: 12px !important;
	line-height: 14px !important;
	font-style: normal !important;
  }
  
  .paola-1 .abbrevation {
	margin-top: -40px;
  }
  
  .patient-baseline img.desktop {
	max-width: 100%;
	margin: 0 auto;
	width: 100% !important;
  }
  
  .oc-efficacy-solo1 #maincontent .chart-sub {
	font-family: "Roboto-Bold" !important;
	font-size: 20px !important;
	line-height: 22px !important;
	color: #004D74 !important;
  }
  
  .oc-efficacy-solo1 .flag-data {
	display: flex;
	justify-content: space-between;
	align-items: self-start;
	height: auto;
	margin-top: 10px;
	margin-bottom: 40px;
  }
  
  .oc-efficacy-solo1 #maincontent img.flag {
	padding: 15px 0;
	max-width: 300px;
	width: 100%;
	margin-top: 0;
  }
  
  .visuali {
	display: flex;
	flex-direction: column;
	align-items: center;
	width: 100%;
  }
  
  .oc-efficacy-solo1 #maincontent .visuali p.head {
	font-size: 20px !important;
	line-height: 12px !important;
	font-family: "Roboto-Bold" !important;
	color: #004D74 !important;
  }
  
  .visual-sec {
	display: flex;
	flex-direction: row;
	justify-content: center;
	width: 100%;
  }
  
  .visual-box {
	background: #004D74;
	width: 100%;
	max-width: 185px;
	height: 60px;
	display: flex;
	align-items: center;
	justify-content: center;
	margin: 12px 6px;
	transform: skewX(-10deg);
	padding: 10px;
	text-align: center;
  }
  
  .visual-box:last-child {
	/*background: #9e9e98;*/
	background: #7E736D;
  }
  
  .visual-box span {
	font-size: 18px;
	line-height: 20px;
	font-family: "Roboto-Bold";
	color: #fff;
	transform: skewX(10deg);
  }
  
  .oc-efficacy-solo1 #maincontent p.foot {
	color: #000000;
	font-size: 16px;
	line-height: 14px;
	font-family: "Roboto-Regular";
	margin-bottom: 5px;
	border: 1px solid #000000;
	padding: 8px;
	width: 100%;
	max-width: 395px;
	text-align: center;
  }
  
  p.median.median-f {
	font-size: 16px !important;
	line-height: 20px !important;
	font-family: "Roboto-Regular" !important;
	color: #000000 !important;
	margin: 0 auto;
	text-align: center;
	padding-bottom: 0;
  }
  
  .paola-1-sec .flag-data .study-design-link {
	padding: 20px 0;
  }
  
  .oc-efficacy-solo1 .paola-1-sec .chart-sub-head {
	font-size: 25px !important;
	line-height: 30px !important;
	font-family: "Roboto-Bold" !important;
	color: #004D74 !important;
	font-style: normal;
  }
  
  .oc-efficacy-solo1 .unprecedented-efficacy,
  .paola-1 .paola-graph-func {
	background-color: #ffffff !important;
  }
  
  .oc-efficacy-solo1 #maincontent img.desktop.chart1 {
	padding-top: 20px !important;
  }
  
  .oc-efficacy-solo1 #maincontent .paola-1-sec .chart-head {
	margin-bottom: 10px !important;
	font-size: 18px !important;
	line-height: 20px !important;
	font-family: "Roboto-Bold" !important;
	color: #004D74 !important;
  }
  
  .oc-efficacy-solo1 #maincontent .paola-1-sec .orange-head {
	font-size: 16px;
	line-height: 22px;
	background: #F6581D;
	color: #000000;
	padding: 2px 8px;
	display: inline-block;
	transform: skewX(-10deg);
  }
  
  .oc-efficacy-solo1 .paola-1-sec .chart-sub-head sup {
	margin-left: 0;
  }
  
  .oc-efficacy-solo1 .study-design.paola-1-sec {
	padding-top: 10px !important;
	margin-top: 0 !important;
	background: #EAF2FA;
  }
  
  .oc-efficacy-solo1 #study-design h2 {
	margin-bottom: 16px;
	font-family: 'Roboto-Bold';
	font-size: 25px;
	line-height: 19px;
	color: #004D74;
  }
  
  .oc-efficacy-solo1 #study-design h3 {
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	font-family: 'Roboto-Bold' !important;
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	width: 925px;
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	width: 100%;
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   /* background-color: #9E9E98;*/
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  /* ====================xxxxxxxxxxxxxxxxxxxx====================== */
  
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	padding-left: 10px;
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	line-height: 24px;
	color: #fff;
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	left: 5px;
	width: 412px;
	height: 50px;
	display: block;
	background-color: #B2D234;
	transform: skewX(-10deg);
	box-shadow: none;
  }
  
  .brca-testing .brca-test-sec .link-bg a:hover,
  .brca-testing .brca-test-sec .link-bg a:focus {
	color: #fff;
	text-decoration: none;
	background-color: #B2D234;
  }
  
  .brca-testing .brca-test-sec .link-bg a:active {
	background-color: #b2d234;
	border: solid 3px #b2d234;
	height: 50px;
  }
  
  .brca-testing .brca-test-sec .link-bg a p.germline.arrow-img {
	font-size: 20px;
	line-height: 20px;
	font-family: "Roboto-Bold";
	color: #004D74;
	background: none;
	font-style: italic;
	display: block;
	text-align: center;
  }
  
  .brca-testing .brca-test-sec .link-bg a p.germline.arrow-img::after {
	content: '';
	border: 4px solid #004d74;
	border-bottom: none;
	border-left: none;
	width: 14px;
	height: 14px;
	position: relative;
	right: -8px;
	top: 0px;
	display: inline-block;
	transform: rotate(48deg);
  }
  
  .brca-testing .brca-test-sec .blue-call-out {
	background: #004E74;
	margin-top: 26px;
	padding: 30px;
	padding-top: 15px;
	transform: skewX(-10deg);
	transform-origin: bottom;
  }
  
  .brca-testing .brca-test-sec h4.h3-head {
	font-size: 30px;
	line-height: 18px;
	font-family: "Roboto-Bold";
	color: #B2D234;
	font-style: normal;
	margin-bottom: 20px;
	margin-left: -5px;
  }
  
  .brca-testing .brca-test-sec p.partner {
	font-size: 16px;
	line-height: 20px;
	color: #004D74 !important;
	font-family: 'Roboto-Regular';
	text-align: left;
	padding-top: 20px !important;
	margin: 0;
  }
  
  
  /*.brca-testing .unprecedented-efficacy {
	background-color: #EAF2FA !important;
  }*/
  
  .brca-testing .lightGreen-box-container {
	margin-left: auto;
	margin-right: 0;
	width: 566px;
	min-height: 60px;
	overflow-x: hidden;
	margin-bottom: 0;
	margin-top: 50px;
  }
  
  .paolacontent-cell li,
  .key-criteria li,
  .paola-1 p,
  .hrd-testing p {
	font-size: 16px;
	line-height: 20px !important;
  }
  
  .hrd-testing .footnote {
	line-height: 14px !important;
	text-indent: -5px;
  }    
  
  .mono .recommended-dosage.rec-dosage {
	height: 255px;
  }
  
  .mono .dose-interruption.rec-dosage {
	height: 257px;
  }
  
  .monotherapy .dosage.doubled-ORR.patient p {
	font-size: 16px !important;
	line-height: 24px !important;
  }
  
  .combi .common-headline h2 {
	font-size: 21px !important;
	line-height: 24px !important;
		font-style: italic;
	margin-top: 6px !important;        
  }
  
  .yellow-approvals h3.blue-3 {
	font-size: 20px !important;
	line-height: 21px !important;
  }
  
  .yellow-approvals p.big-note,
  .yellow-approvals p.dashed-note {
	font-size: 16px !important;
	line-height: 20px !important;
  }
  
  ul.list-capsule li.p-h2::marker {
	color: #004D74;
  }
  
  .oc-safety-tolerability-study19 #adverse-reactions ul.body-foot {
	padding-bottom: 15px !important;
  }
  
  .year-wrap ul.year-bullets {
	padding-left: 8px !important;
  }
  
  .oc-safety-tolerability-solo1 #maincontent .study-design p.blue.blue-org {
	font-family: 'Roboto-Bold';
  }
  
  p.abbr {
	font-size: 12px !important;
	line-height: 18px !important;
	font-family: "Roboto-Light" !important;
  }
  
  .combi p.abbr {
	margin-top: -24px;
	margin-bottom: 50px;
  }
  
  .mono p.abbr {
	font-size: 12px !important;
	line-height: 14px !important;
	font-family: "Roboto-Light" !important;
	margin-top: 10px;
  }
  
  .dose-interruption-body {
	padding: 5%!important;
	padding-bottom: 6%!important;
	padding-left: 40px !important;
  }
  #h2-text {
	display: inline-block !important;
  }

  /* ************** US-87120 ********************* */

  .paola-popup-2.olympia-container .sub-appr-txt p {
    margin-bottom: 130px;
  }

  .paola-popup-2 .solo-paolo .cta1-above-sec {
	position: absolute;
    left: 0;
    background: #B2D234;
    max-width: 350px !important;
    width: 100%;
    /* top: -91px !important; */
    top: -116px !important;
    text-align: left;
    padding: 7.5px 0 7.5px 18px !important;
    pointer-events: none;
    cursor: pointer;
}
.paola-popup-2 .solo-paolo .cta1-above-sec:after {
	content: '';
    position: absolute;
    border-top: 0px solid transparent;
    /* border-bottom: 92px solid transparent !important; */
    border-bottom: 119px solid transparent !important;
    border-left: 38px solid #B2D234 !important;
    top: 0;
    /* left: 99.70% !important; */
    left: 99.50% !important;
}
#us-56792-popup-new .olympia-container a.btn-txt p::after { 
	display: none;
}
#us-56792-popup-new .cta1-above-sec p {
	padding: 0px !important;
}

   /* ************** US-87120 ********************* */
  
  @media screen and (max-width: 1023px) {

	  /* ************** US-87120 ********************* */

	  .paola-popup-2.olympia-container .sub-appr-txt p {
		margin-bottom: 130px;
	  }
	
	  .paola-popup-2 .solo-paolo .cta1-above-sec {
		position: absolute;
		left: 0;
		background: #B2D234;
		max-width: 350px !important;
		width: 90%;
		/* top: -62px !important; */
		top: -79px !important;
		text-align: left;
		padding: 7.5px 0 7.5px 18px !important;
		pointer-events: none;
		cursor: pointer;
	}
	.paola-popup-2 .solo-paolo .cta1-above-sec p{
		font-size: 12px !important;
		line-height: 16px !important;
		margin-bottom: 0px;
	 }
	.paola-popup-2 .solo-paolo .cta1-above-sec:after {
		content: '';
		position: absolute;
		border-top: 0px solid transparent;
		/* border-bottom: 64px solid transparent !important;
		border-left: 23px solid #B2D234 !important; */
        border-bottom: 80px solid transparent !important;
		border-left: 26px solid #B2D234 !important;
		top: 0;
		/* left: 99.10% !important; */
		left: 99.50% !important;
	}
	
	   /* ************** US-87120 ********************* */


  .paola-1 .patient-baseline .hrdPositiveChart {
	  margin: 20px 0 40px;
	}
  .paola-1 #study-ref.paola-study .desktop+ .ftnote1.footnote:last-child {
	  margin-bottom: 8px;
  }
	.paola-1 .paola-study.paola-1-sec .chart-sub-text {
	  font-size: 20px !important;
  }
  .paola1-asco .paola-study.paola-1-sec .chart-sub-text {
	margin-bottom: 20px;
  }
	.add-os-sub p:nth-child(odd) {
	  margin-bottom: 8px;
  }
	p.head-dat {
	  line-height: 12px !important;
  }
	.oc-efficacy-solo1 #maincontent .oc-efficacy-solo1-ftnote p.footnote {
	  font-size: 12px !important;
	  line-height: 16px !important;
  }
	.oc-efficacy-solo1 #maincontent .orr-lynp-container .orr-block p strong {
	  font-family: 'MyriadPro-Regular';
  }
	.oc-efficacy-solo1 #maincontent .orr-lynp-container .orr-block p {
	  font-size: 18px;
	  line-height: 22px;
		font-family: 'MyriadPro-Regular';
			max-width: 268px;
  }
	.oc-efficacy-solo1 #maincontent .orr-lynp-container .orr-lynp .orr-mid-grid .orr-callout p{
	font-size: 24px;
	}
	.oc-efficacy-solo1 .median-pf-container {
	  text-align: center;
	  padding-bottom: 10px;
  }
	.oc-efficacy-solo1 .lightGreen-linkbox {
		text-align: right;
	}
	 .oc-efficacy-solo1 .lightGreen-linkbox .box1{
		text-align: right;
				margin-right: 8px;
	}
	.oc-efficacy-solo1.lightGreen-linkbox span::after {
		right: -22px;
	}
	.oc-efficacy-solo1 .lightGreen-box-container {
	  margin-top: 10px;
  }
	.oc-efficacy-solo1 #maincontent .Investigator-assessed p {
	  font-size: 16px;
	  line-height: 20px;
  }
	.eff-solo1 .study-design.paola-1-sec .content-inner-wrapper {
	  padding-top: 10px;
  }
	.eff-solo1 #maincontent .new-pfs-data h2.chart-sub-head {
	  font-size: 18px !important;
	  line-height: 22px !important;
  }
	.oc-efficacy-solo1 #maincontent .paola-1-sec .orange-head{
	color: #004d74;
	}
	.unprecedented-efficacy.paola-1-sec .content-inner-wrapper > p.chart-sub-head {
	  padding-bottom: 18px;
  }
	.oc-efficacy-solo1 .visual-box span,
	.oc-efficacy-solo1 #maincontent .visuali p.head {
	  font-size: 16px !important;
  }
  .paola-1-sec .flag-data .study-design-link {
	  padding: 20px 0 28px !important;
	}
	.oc-efficacy-solo1 .oc-efficacy-solo1-ftnote {
		background-color: #fff;
		padding-bottom: 15px;
		margin-top: 0;
	}
	p.bluee-box-chart {
		background: #EAF2FA;
		color: #004D74;
		font-size: 16px;
		line-height: 20px;
		font-family: 'MyriadPro-Bold';
		max-width: 224px;
		margin: 0 auto;
		transform: skewX(-10deg);
		padding: 6px 7px;
		text-align: center;
	}
	.paola-1-sec .bevacizumabChart {
		margin: 20px auto 25px auto;
	}
	.paola-graph-func.paola-1-sec .hrdSubgroupAdditional p {
		font-family: 'MyriadPro-Regular';
	}
	.paola-graph-func.paola-1-sec .hrdSubgroupAdditional span {
		font-family: 'MyriadPro-Bold';
	}
	.paola-1 .paola-1-sec .new-pfs-data {
		margin-top: 0px;
	}
	.paola-1 .paola-graph-func.paola-1-sec .new-pfs-data p.chart-sub-head,
	.paola-1 .paola-graph-func.paola-1-sec .new-os-data p.chart-sub-head {
		font-size: 18px !important;
		line-height: 22px !important;
		margin-bottom: 17px;
	}
  .paola-1 .patient-baseline .hrd-table table {
	  width: 100%;
  }
  }
  
  @media screen and (max-width: 991px) {
  
	.brca-testing .brca-test-sec .fda-txt {
		font-size: 16px;
		line-height: 20px;
	}
  
	.brca-testing .brca-test-sec .why-tumor p.fda-txt:last-child {
		font-size: 16px;
		line-height: 20px;
	}
  
	.moa-page p.footnote.bannerfootnote.new.in {
		font-family: Roboto-Regular !important;
	}
  
	.brca-testing .lightGreen-linkbox span::after {
		right: -25px;
		top: 0;
		margin-left: -20px;
	}
  .brca-testing .lightGreen-linkbox div::after {
		right: -95px;
		top: -8px;
	}
	.brca-testing p.footnote {
		font-size: 14px !important;
		line-height: 18px !important;
		font-family: "Roboto-Light" !important;
		margin-bottom: 36px;
	}
	.brca-testing .lightGreen-box-container {
		margin-top: 20px;
	}
	.brca-testing .brca-test-sec .link-bg a p.germline.arrow-img {
		font-size: 16px;
		line-height: 30px;
		text-align: center;
		width: 96%;
	}
	.brca-testing .brca-test-sec .germline {
		padding: 10px;
	}
	.brca-testing .brca-test-sec .blue-call-out {
		padding: 20px;
		padding-top: 30px;
		transform: none;
	}
	.brca-testing .brca-test-sec p.h3-head {
		font-style: italic;
		transform: none;
		color: #B2D234 !important;
	}
	.brca-testing .brca-test-sec .content-section {
		transform: none;
		flex-direction: column;
	}
	.brca-testing .left-link,
	.brca-testing .right-link {
		max-width: 100%;
		padding-right: 0;
	}
	.brca-testing .brca-test-sec .description {
		padding-left: 0px;
	}
	.brca-testing .brca-test-sec .link-bg a {
		position: relative;
		left: 0;
		width: 100%;
		max-width: 333px;
	}
	/* ====================xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx=================== */
	.brca-testing .brca-test-sec .why-tumor .random {
		font-size: 16px;
		line-height: 20px;
	}
	.brca-testing .brca-test-sec .why-tumor h2 {
		font-size: 20px;
		line-height: 24px;
	}
	.hrd-testing .hrd-test-sec .lightGreen-linkbox span::after {
		right: -20px;
	  top: 0;
	  margin-left: -15px;
	}
  .box1{
  padding: 11px 66px 11px 87px!important;
	}
  
  .hrd-testing .hrd-test-sec .box1 span::after {
		right: -16px;
	}
  .hrd-testing .hrd-test-sec .lightGreen-linkbox .box1::after {
		right: -16px!important;
	}
	.hrd-testing .hrd-test-sec .what-box {
		flex-direction: column;
	}
	.hrd-testing .hrd-test-sec .wht_img {
		width: 100%;
		max-width: 320px;
	}
	.hrd-testing .hrd-test-sec .wht_txt {
		width: 100%;
		margin-top: 30px;
	}
	.hrd-testing .hrd-test-sec .wht_txt p {
		font-size: 20px;
		line-height: 24px !important;
	}
	.hrd-testing .hrd-test-sec .wht_txt span {
		font-size: 16px;
		line-height: 20px;
	}
	.hrd-test-sec .block-one p.block-one-text {
		margin-top: 12px !important;
		font-size: 16px;
		line-height: 20px;
	}
	.hrd-testing .hrd-test-sec .callout-block {
		font-style: italic;
		transform: none;
		border-left: none;
		border-top: solid 9px #f7931d;
		padding: 10px;
		left: 0;
	}
	.hrd-testing .hrd-test-sec .callout-block p {
		transform: none;
		font-size: 18px;
		line-height: 22px !important;
	}
	.hrd-testing .hrd-test-sec .block-one p.footnote {
		margin-bottom: 20px;
	}
	.hrd-testing .hrd-test-sec .chart-sub-head {
		font-size: 20px !important;
		line-height: 24px !important;
		margin-top: 20px;
	}
	.hrd-testing .hrd-test-sec .chart-sub-head.key {
		font-size: 18px !important;
		line-height: 20px !important;
		margin-top: 20px;
	}
	.eff-solo2 .lightGreen-box-container {
		margin-top: 20px;
		margin-bottom: 0;
		width: 925px;
	}
	.recurrent-maintenance-Study-19 .paola-1-sec .chart-sub-head {
		font-size: 18px !important;
		line-height: 22px !important;
	}
  .recurrent-maintenance-Study-19 .paola-1-sec .chart-sub-head.lh-30 {
		line-height: 22px !important;
	}
	p.footnote.pt-m-20.pb-m-40 {
		padding: 10px;
	}
	.pt-m-20 {
		padding-top: 20px !important;
	}
  .pb-m-0 {
		padding-bottom: 0 !important;
	}
  .pt-m-0 {
		padding-top: 0 !important;
	}
	.pb-m-40 {
		padding-bottom: 40px !important;
	}
	.eff-solo2 .lightGreen-box-container .lightGreen-linkbox {
		font-size: 16px;
		line-height: 20px;
		padding: 8px 32px 8px 8px;
		border: 4px solid #B2D234;
		padding-right: 40px;
	}
	.eff-solo2 .lightGreen-box-container .lightGreen-linkbox span::after {
		right: -16px;
		top: -6px;
	}
	.oc-efficacy-solo2 #maincontent .bicr.bicr2 p.subheading {
		font-family: "Roboto-Bold" !important;
		font-size: 20px !important;
		line-height: 24px !important;
		color: #004D74;
	}
	.oc-efficacy-solo2 .paola-1-sec .chart-sub-head {
		font-size: 18px !important;
		line-height: 22px !important;
	}
	.oc-efficacy-solo2 .paola-1-sec .chart-sub {
		font-size: 16px !important;
		line-height: 20px !important;
	}
	.orr-block:first-child>p {
		border-bottom: 2px solid #b2d234;
		padding-bottom: 15px;
	}
	.oc-efficacy-solo1 #maincontent .orr-top-content p {
		font-family: "Roboto-Regular";
		font-size: 16px;
		line-height: 20px;
		color: #004D74;
	}
	.oc-efficacy-solo1 #maincontent .orr-top-content h3 {
		font-family: "Roboto-Bold";
		font-size: 20px;
		line-height: 24px;
		color: #004D74;
	}
	.oc-efficacy-solo1 #maincontent .top-img {
		text-align: center;
		width: 100%;
		margin-top: 25px;
	}
	.oc-efficacy-solo1 #maincontent .orr-top-content p.center-text {
		font-size: 20px;
		line-height: 20px;
		font-family: 'MyriadPro-Bold';
	}
	.oc-efficacy-solo1 .orr-block>p {
		width: 100%;
		max-width: 260px;
	}
	.oc-efficacy-solo1 .orr-lynp-container .orr-lynp .orr-mid-grid {
		text-align: center;
		max-width: 315px;
		background-color: #F7FAEB;
		margin: 15px auto;
		height: auto;
		padding: 10px;
		padding-bottom: 20px;
	}
	.oc-efficacy-solo1 #maincontent .bicr h3 {
		font-size: 20px;
		line-height: 24px;
		font-family: "Roboto-Bold";
		color: #004D74;
	}
	.studyDesignTableCell table tr {
		display: flex;
		flex-direction: column;
		justify-content: center;
		align-items: center;
	}
	.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable .studyDesignTableCell td.lhsSDTable {
		width: 100%;
	}
	.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable .studyDesignTableCell td.lhsSDTable img {
		width: 100%;
		margin: 10px auto;
		padding: 0;
	}
	.oc-efficacy-solo1 #maincontent #study-design .studyDesignTable .studyDesignTableCell td.rhsSDTable {
		width: 100%;
	}
	.oc-efficacy-solo1 #study-design h2 {
		margin-bottom: 12px;
		font-family: 'Roboto-Bold';
		font-size: 20px;
		line-height: 24px;
		color: #004D74;
	}
	.oc-efficacy-solo1 #study-design h3 {
		margin-bottom: 18px;
		font-family: 'Roboto-Bold';
		font-size: 18px;
		line-height: 19px;
		color: #004D74;
	}
	.oc-efficacy-solo1 #maincontent .paola-1-sec .chart-head {
		font-size: 13px !important;
		line-height: 16px !important;
		padding-right: 10px !important;
		margin-bottom: 10px !important;
	}
	.oc-efficacy-solo1 #maincontent .paola-1-sec .orange-head {
		font-size: 16px;
		line-height: 22px;
		display: block;
		width: fit-content;
		padding: 1px 8px;
		margin-bottom: 16px;
	}
	.oc-efficacy-solo1 #maincontent .chart-sub {
		font-size: 18px !important;
		line-height: 22px !important;
	}
	.oc-efficacy-solo1 .paola-1-sec .chart-sub-head {
		font-size: 20px !important;
		line-height: 24px !important;
	}
	.paola-1-sec .flag-data .study-design-link {
		padding: 20px 0;
		margin: 0 auto;
	}
	p.median.median-f {
		text-align: left;
		padding-right: 0;
		margin: 0 auto !important;
	}
	.oc-efficacy-solo1 #maincontent img.flag {
		padding: 15px 0;
		max-width: 395px;
		width: 100%;
		margin-top: 0;
	}
	.oc-efficacy-solo1 .flag-data {
		display: flex;
		flex-direction: column;
		align-items: center;
		margin-bottom: 0;
	}
	.patient-baseline .calloutDemographics {
		border-top: 8px solid #F7931D !important;
		border-left: none !important;
		transform: none !important;
	}
	.patient-baseline.paola-1-sec .calloutDemographics p {
		transform: none;
	}
	.paola-1 .paola-1-sec p.patient-enrolled {
		font-size: 18px !important;
		line-height: 22px;
		margin-bottom: 25px !important;
		margin-top: 5px !important;
	}
	.paola-1 .patient-baseline .hrdPositiveChartLhs {
		width: 100%;
		margin-bottom: 20px;
	}
	.paola-1 .patient-baseline .hrdPositiveChartRhs {
		width: 100%;
		max-width: 328px;
		margin-bottom: 20px;
	}
	.paola-1 .patient-baseline .hrd-table {
		width: 100%;
		margin-bottom: -20px;
	}
	.paola-1 .patient-baseline .hrdPositiveChart {
		flex-direction: column;
	}
	.paola-1 .patient-baseline.paola-1-sec {
		background-color: #ffffff;
		margin-top: 0;
		overflow-x: hidden;
	}
	.paola-1 .paola-1-sec .paolacontent-cell {
		padding: 20px 0 0 0;
	}
	#study-ref .ftnote1.footnote {
		margin-top: 20px;
		margin-bottom: 0;
	}
	.hrd-box {
		width: 100%;
		max-width: 100%;
	}
	.mpfs-box {
		width: 100%;
		max-width: 100%;
	}
	.hrd-sec {
		margin-top: 12px;
		margin-bottom: 20px;
	}
	.paola-study.paola-1-sec img.mobile {
		max-width: 100%;
		margin-bottom: 10px;
	}
	.mpfs-sec {
		display: flex;
		margin-bottom: 10px;
		flex-direction: column;
	}
	.mpfs-list {
		text-indent: -22px;
		padding-left: 24px;
	}
	.paola-1-sec .mobile.new-os-data-m {
		margin-top: 16px;
	}
	.paola-1-sec .add-os-sub {
		background: #D9E4EA;
		height: auto;
		padding: 12px 20px 16px 20px;
		width: 100%;
		margin-bottom: 10px;
	}
	.paola-1-sec .mbl-green-txt {
		font-family: "Roboto-Bold";
		/*color: #B2D234;*/
	color: #7F9C21;
		font-size: 20px;
		line-height: 25px;
		margin-bottom: 10px;
	}
	.paola-1-sec p.newos-foot {
		font-size: 13px !important;
		line-height: 16px !important;
		font-family: 'Roboto-Regular' !important;
	}
	.paola-graph-func.paola-1-sec .hrdSubgroupAdditional {
		padding: 20px 0 5px;
	}
	.paola-1 .paola-1-sec .chart-head {
		font-size: 13px !important;
		line-height: 16px !important;
		padding-right: 0px !important;
		margin-bottom: 8px !important;
	}
	.paola-1 .paola-1-sec .chart-head em {
		font-family: 'Roboto-Medium' !important;
	}
	.paola-1 .paola-1-sec .orange-head {
		font-size: 16px;
		line-height: 22px;
		display: block;
		width: fit-content;
		padding: 1px 8px;
		margin-bottom: 16px;
	}
  .evidence {
	  display : none;
  }
	.paola-graph-func.paola-1-sec .hrdSubgroup {
		padding: 13px 20px 13px 10px;
	}
	.paola-graph-func.paola-1-sec .hrdSubgroup {
		margin: 10px 0 0px;
	}
	p.median {
		font-size: 16px !important;
		line-height: 20px !important;
	}
	.home-sec .smal-txt {
		font-size: 10px;
		line-height: 12px;
	}
	.home-sec .norml-txt {
		font-size: 13px;
		line-height: 14px;
		margin-top: -4px;
	}
	.home-sec .m-callouts .m-callout .m-callout-inner p {
		font-size: 18px;
		line-height: 20px;
	}
	.landing-home .m-callouts .m-callout .m-callout-but a {
		margin-top: 0;
		box-shadow: none;
		-webkit-box-shadow: none;
		font-size: 20px;
		line-height: 20px;
		height: 50px;
		padding: 13px;
		text-align: left;
		padding-left: 34px;
		font-style: italic;
	}
	.home-sec .ocbanner-content-new {
		padding: 16px 20px;
	}
	.home-sec .ocbanner-content-new .paola {
		font-size: 16px;
		line-height: 20px;
		transform: none;
	}
	.home-sec .ocbanner-content-new .solo {
		font-size: 16px;
		line-height: 20px;
		transform: none;
	}
  
  
	.paola-1-sec .study-design-link {
		flex-direction: column;
		align-items: center;
	  margin-bottom: 60px;
	}
	.paola-1-sec .study-design-link .study-design-but {
		width: 100%;
		max-width: 334px;
		display: flex;
		justify-content: space-evenly;
		align-items: center;
		text-decoration: none;
		margin-bottom: 10px;
		padding: 10px 55px;
	}
	.paola-1-sec .heading {
		display: flex;
		align-items: self-start;
		flex-direction: column;
	}
	.paola-1 .paola-1-sec .paola-img {
		margin: 0;
		margin-bottom: 5px;
		display: block;
	}
	.foot_note .font-light {
		font-size: 12px;
		line-height: 14px;
	}
	.paola-1 .paola-graph-func.paola-1-sec h2 {
		font-size: 16px;
		line-height: 20px;
	}
	.paola-1 .paola-1-sec .chart-sub-text {
		font-size: 18px !important;
		line-height: 22px !important;
	}
	.paola-1 .paola-1-sec .chart-sub-head {
		font-size: 20px !important;
		line-height: 24px !important;
		margin-bottom: 10px;
	}
  }
  
  @media screen and (max-width: 767px) {

		  /* ************** US-87120 ********************* */
		  .paola-popup-2 .solo-paolo .cta1-above-sec {
			/* top: -63px !important; */
			top: -79px !important;
			text-align: left;
			padding: 7.5px 0 7.5px 18px !important;
		}
		.paola-popup-2 .solo-paolo .cta1-above-sec:after {
			content: '';
			position: absolute;
			border-top: 0px solid transparent;
			/* border-bottom: 65px solid transparent !important; */
			border-bottom: 81px solid transparent !important;
			/* border-left: 20px solid #B2D234 !important; */
			border-left: 26px solid #B2D234 !important;
			top: 0;
			left: 99.50% !important;
		}
		
		   /* ************** US-87120 ********************* */


	.eff-solo2 .lightGreen-box-container .lightGreen-linkbox span::after {
	  right: -8px;
	  margin-right: -14px;
   }
   .eff-solo2 .lightGreen-box-container .lightGreen-linkbox {
	 text-align: right;
	}
	.recurrent-maintenance-Study-19 .unprecedented-efficacy.paola-1-sec {
		background-color: #E7EEF2 !important;
		margin-top: 20px;
	}
	.recurrent-maintenance-Study-19.eff-19 p.footnote, .brca-testing p.footnote {
		font-size: 12px !important;
	}
	.brca-testing.new-brca p.footnote {
		font-size: 12px !important;
		line-height: 14px !important;
	}
	.brca-testing .brca-test-sec .testing {
		padding: 0;
	}
	.brca-testing .brca-test-sec .why-tumor {
		max-width: 100%;
		margin: 0 auto;
	}
	.recurrent-maintenance-Study-19 div#approvUse {
		margin-top: -100px !important;
		padding-top: 125px !important;
	}
	.recurrent-maintenance-Study-19 .graph-img {
		margin-bottom: -10px !important;
		margin-top: 20px !important;
	}
	.recurrent-maintenance-Study-19 .paola-1-sec p.footnote {
		font-size: 14px !important;
	}
	.recurrent-maintenance-Study-19 .study-design img {
		margin-top: 18px !important;
		margin-bottom: 20px;
	}
	.recurrent-maintenance-Study-19 .chart {
		display: flex;
		width: 100%;
		max-width: 335px !important;
		margin: 0 auto !important;
		flex-direction: column;
	}
	.recurrent-maintenance-Study-19 .chart>div {
		display: flex;
		width: 100%;
		max-width: 100% !important;
		margin: 0 !important;
		transform: skewX(0deg) !important;
		margin-right: 0 !important;
		height: auto;
		margin-top: 0 !important;
	}
	.recurrent-maintenance-Study-19 .chart p {
		margin: 0 !important;
		color: #ffffff !important;
		padding: 5px 25px !important;
		font-family: 'Roboto-Medium' !important;
		transform: skewX(0deg) !important;
		font-size: 16px !important;
		line-height: 18px !important;
		width: 100%;
	}
	.oc-efficacy-solo2 .bicr2 .median-pfs {
		display: flex;
		width: 100%;
		max-width: 335px;
		margin: 0 auto;
		flex-direction: column;
	}
	.oc-efficacy-solo2 .bicr2 .median-pf-container {
		text-align: center;
		margin: 30px 0 26px 0;
	}
	.oc-efficacy-solo2 .bicr2 .median-pf-container-media {
		display: flex;
		width: 100%;
		max-width: 335px;
		margin: 0 auto;
		flex-direction: column;
	}
	.oc-efficacy-solo2 .bicr2 .median-pf-container .median-pfs>div {
		display: flex;
		width: 100%;
		max-width: 100% !important;
		margin: 0 !important;
		transform: skewX(0deg) !important;
		margin-right: 0 !important;
		height: auto;
		margin-top: 0 !important;
	}
	.oc-efficacy-solo2 .bicr2 .median-pf-container .median-pfs p {
		margin: 0 !important;
		color: #ffffff !important;
		padding: 5px 25px !important;
		font-family: 'Roboto-Medium' !important;
		transform: skewX(0deg) !important;
		font-size: 16px !important;
		line-height: 18px !important;
		width: 100%;
	}
	.oc-efficacy-solo1 #maincontent #study-design .Randomized-container-media {
		display: flex;
		width: 100%;
		max-width: 335px;
		margin: 0 auto;
		flex-direction: column;
	}
	.oc-efficacy-solo1 #maincontent #study-design .Randomized-container-media div {
		display: flex;
		width: 100%;
		transform: skewX(0deg) !important;
		margin-right: 0 !important;
		height: 68px;
		margin-top: 0 !important;
	}
	.oc-efficacy-solo1 #maincontent #study-design .Randomized-container-media div:first-child {
		margin-top: 10px !important;
	}
	.oc-efficacy-solo1 #maincontent #study-design .Randomized-container .Randomized-container-media>div p {
		margin: 0;
		color: #ffffff;
		padding: 5px 25px;
		font-family: 'Roboto-Bold';
		transform: skewX(0deg);
		font-size: 16px;
		line-height: 20px;
		width: 100%;
		display: block;
		height: auto;
	}
	.oc-efficacy-solo1 #maincontent #study-design .Randomized-container {
		text-align: center;
		margin: 30px 0 26px 0;
	}
	.Investigator-assessed {
		flex-direction: column;
		align-items: center;
	}
	.Investigator-assessed .img img {
		padding: 0 !important;
		margin: auto;
		margin-bottom: 10px;
	}
	.oc-efficacy-solo1 .median-pfs {
		display: flex;
		width: 100%;
		max-width: 335px;
		margin: 0 auto;
		flex-direction: column;
	}
	.oc-efficacy-solo1 .median-pf-container .median-pfs div {
		max-width: 100%;
		vertical-align: top;
		display: flex;
		width: 100%;
		transform: skewX(0deg) !important;
		margin-right: 0 !important;
		height: 68px;
		margin-top: 0 !important;
		margin: 0 auto;
		justify-content: center;
	}
	.oc-efficacy-solo1 #maincontent .median-pf-container .median-pfs p {
		margin: 0;
		color: #ffffff;
		padding: 5px 25px;
		font-family: 'Roboto-Bold';
		transform: skewX(0deg);
		font-size: 16px;
		line-height: 20px;
	}
  }
  
  @media screen and (min-width:992px) {
	.combi-rec-dose.container-center ul li.dashed-note {
		margin-bottom: 10px;
		text-indent: -8px;
		padding-left: 25px;
	}
	.eff-solo1 .common-headline .container-center {
		padding-right: 0;
		padding-left: 0;
	}
  
	.eff-solo2 .common-headline .container-center {
		padding-right: 0;
		padding-left: 0;
	}            
	.oc-efficacy-solo2 .common-headline h1 {
		padding-right: 0 !important;
	}
	.brca-testing .brca-test-sec .blue-call-out {
		height: 253px;
	}
	.paola-1 .patient-baseline .hrdPositiveChartLhs>p {
		padding-right: 42px;
	}
	.recurrent-maintenance-Study-19 .paola-1-sec .chart-sub-head.lh-30 {
		line-height: 30px !important;
	}
	.recurrent-maintenance-Study-19 .study-design .graph-img img {
		margin-top: 0px !important;
	}
	.recurrent-maintenance-Study-19 .graph-img {
		text-align: center;
		margin-bottom: 0 !important;
	}
	.oc-efficacy-solo2 .pfs-4x.paola-1-sec .content-inner-wrapper {
		padding-top: 0;
	}
	.paola-1 .paola-enrolled {
		position: relative;
		margin-bottom: 20px !important;
	}
	.paola-enrolled.paola-1-sec {
		margin-top: -33px;
	}
	.paola-1 .abbrevation {
		margin-top: -65px;
	}
	.paola-1 .paolacontent-cell .paolacontent-cell-1 div {
		margin-right: 30px;
	}
	.paola-1 .paolacontent-cell .paolacontent-cell-2 {
		width: 50%;
	}
	.paola-1 .paolacontent-cell .paolacontent-cell-1 {
		margin-top: 30px !important;
	}
	.paola-1 .paolacontent-cell .paolacontent-cell-2 {
		margin-top: 30px !important;
	}
	.paola-1 .paola-1-sec .paolacontent-cell {
		display: flex;
	}
	.paola-1 .paola-1-sec .paolacontent-cell-1 {
		display: flex;
	}
  }
  
  @media only screen and (min-width: 768px) and (max-width: 1024px) {
	.paola-1 .paola-1-sec .paola-img {
		margin: 0;
		margin-bottom: 5px;
		display: block;
	}
	  .paola-study.paola-1-sec img.mobile {
		   width: 100%; 
	  }
  }
  
  @media screen and (min-device-width: 481px) and (max-device-width: 1024px) and (orientation: portrait) {
	p.median.median-f {
		margin-left: auto;
		margin-bottom: 0 !important;
		margin-top: 0px !important;
	}
  }
  
  @media only screen and (min-width: 1024px) {
	.grid-section.new-grid {
		max-width: 100% !important;
		margin: 0 auto;
		display: flex;
		padding-bottom: 50px !important;
		padding-top: 25px !important;
	}
	.grid-section.new-grid .section-collect span.note {
		width: 100% !important;
	}
	.grid-section.new-grid .left-img {
		margin-top: 40px;
	}
	.grid-section.new-grid .section-collect span.note {
		width: 100% !important;
		height: 150px;
	}
	.grid-section.new-grid img.desktop.img-responsive.re-helix {
		width: auto;
	}
	.grid-section.new-grid .section-collect span:last-child {
		width: 85%;
		margin: 0px auto;
		text-align: center;
		display: block;
		position: relative;
		top: 24px !important;
		font-size: 16px;
		line-height: 20px;
		font-family: "Roboto-Bold";
		color: #004D74;
	}
	.grid-section.new-grid .section-collect.tissue span.collect {
		top: 50px;
	}
	.grid-section.new-grid .collect {
		padding-top: 0;
	}
	.grid-section .section-collect.female_icon {
		margin: 0 30px 0 0;
	}
	.grid-section .section-collect.results {
		margin: 0 0 0 30px;
	}
	.grid-section.new-grid .arrow {
		display: flex;
	}
  }
  
  @media only screen and (max-width: 1023px) {
	.grid-section.new-grid .section-collect span:nth-child(3) {
		position: relative;
		top: 15px;
		left: 0 !important;
		width: 300px !important;
		margin: 0;
	}
	.grid-section.new-grid .section-collect span:last-child {
		font-size: 16px;
		line-height: 22px;
		font-family: "Roboto-Bold";
		color: #004D74;
	}
	.grid-section.new-grid .down-img {
		border-top: 2px solid #b2d234;
		display: block;
		position: relative;
		top: 20px;
	}
	.grid-section.new-grid .arrow:first-child .down-img {
		top: -20px;
		margin-top: 48px;
	}
	.grid-section.new-grid .down-img img {
		left: 5px;
		top: -10px;
		transform: rotate(90deg);
		width: 18px !important;
		margin-top: 0;
		margin-bottom: 5px;
	}
	.grid-section.new-grid .section-collect {
		width: 100% !important;
		max-width: 375px;
		margin: 0 auto;
		justify-content: center;
	}
	.grid-section.new-grid .section-collect span:nth-child(2) {
		min-width: 126px;
	}
	.grid-section.new-grid .section-collect span:nth-child(2) img {
		width: 100% !important;
		margin: 0 auto !important;
		max-height: 100px;
		max-width: 80px;
	}
    .mono .recommended-dosage.rec-dosage {
        height: auto !important;
        margin-bottom: 26px;
    }
    .mono .dose-interruption.rec-dosage {
        height: auto !important;
    }

  }
  
  @media (max-width: 767px) {
	.grid-section.new-grid {
		max-width: 100% !important;
		margin: 28px auto;
		padding-bottom: 14px;
	}
	.grid-section.new-grid .section-collect span:nth-child(2) {
		min-width: 110px;
	}
	.grid-section.new-grid .section-collect .collect.receive {
		top: 35px !important;
		left: 3px;
	}
	.grid-section.new-grid .section-collect .collect {
		top: 15px !important;
		left: -8px;
	}
	.paola-1.oc-safety-tolerability-solo1 .callout-block {
		padding: 10px 10px!important;
		padding-bottom: 10px !important;
		margin: 25px -10px 50px -10px!important;
		height: auto;
	}
  }
  .chart-head{
  
	display: inline-block;
  }
  .h2-text {
	display: inline-block;
	padding-left: 4px;
  }
  
  .sup{
  font-family: "Roboto-Bold" !important;
	color: #004D74 !important;
	font-size: 12px;
	}
  .patient-head {
	margin-bottom: 0px!important;
  }
  
  em sup.noskew {
	display: inline-block;
	transform: skewX(10deg) !important;
  }
  .fixed-font20-24 {
		font-size: 20px !important;
		line-height: 24px !important;
  } 
  @media only screen and (max-width: 374px) { 
	  .paola-1 .paolacontent-cell .paolacontent-cell-2 .cell-head {
		  max-width: 100%;
	  }
	  .footer ul li:nth-child(2) {
		  max-width: 127px;
	  }
	  .mobile_pi {
		  left: 9%;
	  }
	  .paola-1 .patient-baseline .hrdPositiveChartRhs {
		  margin: 0 auto 20px;
	  } 
	  .paola-1-sec .study-design-link .study-design-but {
		  padding: 10px 35px;
	  }
	  .neww-table.safety-olympia-table.sp1-table3 .reaction-name {
		  font-size: 12px !important;
	  }
  }
  @media only screen and (min-width: 376px) and (max-width: 1023px) { 
	  .paola-1 .paolacontent-cell .paolacontent-cell-2 .cell-head {
		  width: 100%;
	  }
	  .paola-1 .patient-baseline .hrdPositiveChartRhs {
		  margin: 0 auto 20px;
	  }
        /* compatability 87120 */
        .paola-popup-2.olympia-container .sub-appr-txt p {
            margin-bottom: 0px !important;
        }
        /* compatability 87120 */
  }
  @media only screen and (min-width: 992px) and (max-width: 1023px) {
	  .mpfs-sec > div {
		  width: 50%;
		  margin: 0 15px;
	  }
    /* compatability 87120 */
    .paola-1.paola-veeva .paola-1-sec .paolacontent-cell-1 {
        display: initial;
    }
    .paola-1.paola-veeva .patient-baseline.paola-1-sec {
        margin-top: 0px;
    }
    .combination-therapy .dosecallout.flex_two_three .callout.callout2 .image img {
        width: 80%;
        margin-left: 42px;
    }
    .combination-therapy .dosecallout .callout .image img {
        margin-left: 42px;
        width: 80%;
    }
    /* compatability 87120 */
  }
  @media only screen and (min-width: 992px) and (max-width: 1003px) {
	  .paola-1-sec .study-design-link {
		  flex-direction: column;
		  align-items: center;
		  margin-bottom: 60px;
	  } 
	  .paola-1 .patient-baseline.paola-1-sec {
		  margin-top: 0px;
	  }                                                
  }
  @media only screen and (min-width: 768px) and (max-width: 991px) {
	  #header .mob-container .search-box>.search form button#searchform {
		  width: 35px;
		  height: 35px;
		  margin-top: -35px;
		  top: auto;
	  }
	  #header .mob-container .search-box .search form button#searchform.glyphicon-search:before {
		  top: 6px;
	  }  
  /* compatability 87120 */
    .home.landing-home #maincontent .hero-content {
        margin-bottom: 20px;
    }
    .combination-therapy .dosecallout.flex_two_three .callout.callout2 .image img {
        width: 80%;
        margin-left: 42px;
    }
    .combination-therapy .dosecallout .callout .image img {
        margin-left: 42px;
        width: 80%;
    }
      
  /* compatability 87120 */
                                   
  }

  @media only screen and (min-width: 600px) and (max-width: 767px) {
    .combi p.abbr {
        margin-top: 10px;
        margin-left: 10px;
    }
  }

  /* compatability 87120 */
  @media only screen and (min-width: 500px) and (max-width: 767px) {
    .combination-therapy .dosecallout.flex_two_three .callout.callout2 .image img {
        width: 60%;
        margin-left: 40px;
    }
    .combination-therapy .dosecallout .callout .image img {
        margin-left: 40px;
        width: 60%;
    }
  }

  @media only screen and (min-width: 320px) and (max-width: 360px) {
    .landing-home .m-callouts .m-callout .m-callout-but a {
        font-size: 15px;
    }
    .paola-1.oc-safety-tolerability-solo1 .sp1-table3 .table-legend>ul li {
        font-size: 12px !important;
        line-height: 16px;
    }
    .combination-therapy .green-box-container {
        max-width: 320px;
    }
    .combination-therapy .neww-table.dosing-c-tab td, .combination-therapy .neww-table.dosing-c-tab th {
        font-size: 14px;
        line-height: 20px;
    }
    .combination-therapy .dosecallout.flex_two_three .callout.callout2 .image img {
        width: 85%;
        margin-left: 40px;
    }
    .combination-therapy .dosecallout .callout .image img {
        margin-left: 40px;
        width: 85%;
    }
    .combination-therapy .flex_two_one .image img {
        width: 110px;
    }
  }
  /* compatability 87120 */
  
  /******month violater style starts here****** 
  .bcam-bg.container {
	background: #00AEB9;
  position: absolute;
	top: 141px;
  }
.global-redesign.oc-tumor-type:has(.bcam-bg) #maincontent {
    margin-top: 202px !important;
}
  
  .bcam-content.container-center {
	width: 100%;
	font-size: 16px;
	color: #fff;
	font-family: 'Roboto-Regular';
	margin: 0 auto;
	padding: 0;
  }
  
  .bcam-content .ribbontxt a {
	font-size: 16px;
	color: #fff;
	font-family: 'Roboto-Regular';
	text-decoration: underline;
  }
  .bcam-content .ribbon {
	margin-left: 32px;
	margin-right: 20px;
	display: inline-block;
  }
  .home main#maincontent {
	margin-top: 192px !important;
  }
  .outside-rep-section {
	  z-index: 1011;
  }
  .home main#maincontent {
	margin-top: 189px !important;
  }
  
  
  @media (max-width: 1003px) {
	.bcam-bg .bcam-content .ribbontxt {
		font-size: 13px;
		text-align: center;
		position: relative;
		margin-left: 0px;
		width: 100%;
		display: block;
		padding: 10px 0;
	}
	.bcam-content.container-center {
		padding: 0;
	}    
	.bcam-content .ribbon {
		position: absolute;
		opacity: 0.3;
	}
	.bcam-bg .bcam-content .ribbontxt {
		display: block;
		padding: 10px 40px ;
	}
  
	.bcam-content .ribbontxt a {
		font-size: 14px;
	}
  .home main#maincontent {
	  margin-top: 151px !important;
  }
  .bcam-bg.container {
	  top: 159px;
      height: 59px;
  }
.global-redesign.oc-tumor-type:has(.bcam-bg) #maincontent {
    margin-top: 218px !important;
}
  .home-landviva span.ribbon img {
	width: 65% !important;
  }
    .home.esmo-body main#maincontent {
        margin-top: 188px !important;
    }
  }
  @media only screen and (max-width: 574px){
	.home-landviva span.ribbon img {
	  width: 96% !important;
	}
  
  }
  
  @media only screen and (min-width: 570px) and  (max-width: 574px) {
  .home main#maincontent {
	  margin-top: 132px !important;
  }
   .home-landviva span.ribbon img {
	  width: 65% !important;
  }
  }
  @media only screen and (min-width: 575px) and  (max-width: 767px) {
	.home main#maincontent {
	  margin-top: 132px !important;
  }
  }
  
  @media only screen and (min-width: 768px) and  (max-width: 1003px) {
	.home main#maincontent {
	  margin-top: 128px !important;
  }
  }
  
  @media only screen and (min-width: 1004px) and  (max-width: 1265px) {
  #header .indication-selector .header-dropdown ul li.init span.child-inner {
	  padding: 0 5px 0 11px;
  } 
  } 
  
  /******month violater style ends here*******/      
  
  
   .pink {
	  color: #ff00c6 !important;
  }

  /* 10 years lynparza US-87120 */
.top-bg-text-new-layout {
    position: absolute;
    right: 148px;
    top: 9.5%;
    max-width: 290px;
}
.top-bg-text-new-layout .home-head-text {
    color: #004D74;
    font-family: 'Roboto-Bold';
    display: inline-block;
}
.top-bg-text-new-layout .home-head-text.home-head-text1 {
    font-size: 11px;
    line-height: 14px;
    margin-bottom: 6px;
}
.top-bg-text-new-layout .home-head-text.home-head-text2 {
    font-size: 14px;
    line-height: 16px;
    margin:0px;
}

.left-10year-section {
    position: relative;
    top: 33px;
    left: -8px;
}
.left-10year-section .bg-green-10years {
    transform: skewX(-5deg);
    /* display: block; */
    background: #b2d234de;
    max-width: 414px;
    width: 100%;
    height: 100px;
    position: absolute;
    left: 1px;
    top: -5px;
    padding: 8px;
}
.left-10year-section .bg-blue-10years {
    max-width: 414px;
    width: 100%;
    height: 100px;
    display: flex;
    background-color: #004D74;
    transform: skewX(-5deg);
    position: absolute;
    left: -6px;
    top: -13px;
    justify-content: center;
    align-items: center;
}
.left-10year-section .bg-blue-10years .img-10years {
    margin-left: 157px;
    transform: skewX(5deg);
    margin-top: -10px;
}
.left-10year-section .bg-blue-10years .text-10years {
    margin-left: 15px;
    transform: skewX(5deg);
}
.left-10year-section .bg-blue-10years .text-10years p {
    margin-bottom: 0px;
    color: #ffffff;
    font-size: 12px;
    font-family: 'Roboto-Regular';
    line-height: 16px;
}


/* media query */
@media screen and (min-width: 2021px) {
    .top-bg-text-new-layout {
        right: 427px;
    }
}
@media only screen and (min-width: 1899px) and  (max-width: 2020px) {
	.top-bg-text-new-layout {
        right: 380px;
    }
	.landing-home .callouts {
        right: 391px;
    }
}

@media screen and (min-width: 1899px) {
    .top-bg-text-new-layout {
        position: absolute;
        /* right: 427px; */
        top: 35.3%;
    }
}

@media only screen and (min-width: 1024px) and  (max-width: 1365px) {
    .top-bg-text-new-layout {
        right: 7%;
        top: 5.5%;
    }
}
@media only screen and (min-width: 1024px) and  (max-width: 1250px) {
	.landing-home .container-center.graph {
        margin-top: 55px;
    }
}
@media only screen and (min-width: 1024px) and  (max-width: 1150px) {
    .left-10year-section {
        top: 18px;
    }
    .left-10year-section .bg-blue-10years, .left-10year-section .bg-green-10years {
        max-width: 296px;
    }
    .left-10year-section .bg-blue-10years .img-10years {
        margin-left: 50px;
    }
    .landing-home .callouts {
        top: 28.3%;
    }
}
@media screen and (max-width: 1023px){
    .top-bg-text-new-layout {
        position: static;
        max-width: 100%;
        background: #b2d234de;
        padding: 20px 51px 17px 20px;
    }
    .top-bg-text-new-layout .home-head-text.home-head-text1{
        font-size: 10px;
        line-height: 12px;
        margin-bottom: 3px;
    }
    .top-bg-text-new-layout .home-head-text.home-head-text2{
        font-size: 13px;
        line-height: 14px;
        margin-bottom: 0px;
    }

    .left-10year-section .bg-green-10years {
        max-width: 268px;
        position: absolute;
        left: 0;
        top: -6px;
    }
    .left-10year-section .bg-blue-10years {
        max-width: 268px;
        left: -6px;
        top: -13px;
    }
    .left-10year-section .bg-blue-10years .img-10years {
        margin-left: 15px;
    }

}

@media screen and (max-width: 991px){
    .landing-home .landing-hero-image {
        background-image: url(/content/dam/physician-services/us/590-lynparza-hcp-branded/hcp-oc/desktop/oc-bg-home1.jpg);
    }
    .landing-home .OCBannerFootnoteright {
        display: none;
    }
}
@media only screen and (min-width: 768px) and  (max-width: 991px) {
	.left-10year-section {
		top: 20px;
	}
}
@media screen and (max-width: 767px){
    .landing-home .landing-hero-image {
        height: calc(100vw* 1.1);
        background-size: contain;
    }
}
@media only screen and (min-width: 520px) and  (max-width: 635px) {
    .landing-home .landing-hero-image {
        height: calc(100vw* 1.1);
    }
}
@media only screen and (min-width: 391px) and  (max-width: 519px) {
    .landing-home .landing-hero-image {
        height: calc(100vw* 1.26);
        background-size: contain;
    }
	.left-10year-section {
		top: 20px;
	}
}
@media screen and (max-width: 390px){
    .landing-home .landing-hero-image {
        height: calc(100vw* 1.33);
        background-size: contain;
    }
}
@media screen and (max-width: 374px){
    .landing-home .landing-hero-image {
        height: calc(100vw* 1.34);
        background-size: contain;
    }
    .left-10year-section {
        top: 15px;
    }
}
@media only screen and (min-width: 320px) and  (max-width: 351px) {
	.landing-home .landing-hero-image {
        height: calc(100vw* 1.4);
        background-size: contain;
    }
}

@media screen and (min-width: 992px) and (max-width: 1023px) {
    .landing-home .landing-hero-image.home-10y-banner {
		background-position-y: 74px;
	}
}
/* media query */


  /* 10 years lynparza US-87120 */