/** START- DOSING AND MANAGEMENT ****/
/*.mCustomScrollbar,
.mCustomScrollbar.mCS_touch_action,
.mCustomScrollbar.mCS_touch_action .mCS-aviva.mCSB_scrollTools {
	-ms-touch-action: auto;
	    touch-action: auto;
}
 
.mCustomScrollBox {
	-ms-touch-action: pan-x;
	    touch-action: pan-x;
}

.mCustomScrollBox.mCSB_vertical_horizontal {
	-ms-touch-action: auto;
	    touch-action: auto;
}

.mCustomScrollBox.mCSB_horizontal {
	-ms-touch-action: pan-y;
	    touch-action: pan-y;
}
.mCustomScrollBox.mCSB_horizontal { touch-action: pan-y pinch-zoom; }
.mCustomScrollbar {
    touch-action: initial
}*/
/** START - COMMON SETTINGS **/

.hideContent {
  display: none;
}

.mobile {
  display: none;
}

.desktop {
  display: block;
}


.boldText {
  font-family: "Roboto-Bold";
}

.italicText {
  font-style: italic;
}

.table {
  font-size: 16px;
}
.ipad {display:none;}

/*table.table thead tr th {
  padding: 15px 50px;
  text-align: center;
}*/

table.table td:first-child {
  width: 24%;
}

table.table thead tr th:first-child {
  text-align: left;
}

table.table td {
  padding: 15px;
}
.consider-prescribing .footnote.toclear {
  text-align: left;
  clear: both;
  padding-top: 25px;
}

.dosecallout .heading h3 {
 color: #F7931D;
 font-family: "Roboto-Bold";
 font-size: 20px;
 border-bottom: 3px solid #B2D234;
 padding-left:52px;
 padding-bottom:5px;
}
.dosecallout .heading h3::before {
 content:"1";
 border-radius:50%;
 background-color: #004d74;
 color: #f7931d;
 width: 44px;
 height: 44px;
 font-size: 22px;
 padding: 10px 15px;
  position:absolute;
  left:-3px;
  top:25px;
}
.dosecallout p {line-height:19px!important;}
.dosecallout.flex_two_two .heading h3::before {
  content:"2";
}
.dosecallout.flex_two_three .heading h3::before {
  content:"3";
}
.dosecallout .callout {
  margin-top:36px;
}
.dosecallout .callout .text {
  max-width:55%;
  float:left;
}
.dosecallout.flex_two_two .callout .text {
 max-width:56%;
}
.dosecallout.flex_two_two .callout .image img {
 margin-left:20px;
}
.dosecallout .callout .image {
  width:40%;
  float:left;
}
.dosecallout .callout .text .callout-heading {
  font-size: 14px!important;
  color: #004d74;
  font-family: "Roboto-Bold"!important;
}
.dosecallout .callout .text .callout-text {
  font-size: 14px!important;
  color: #333333;
  margin-top:-10px;
}
.dosecallout .AR {
  margin-top:36px;
}
.dosecallout .AR p {
  font-size: 14px!important;
  font-family: "Roboto-Bold"!important;
  color: #004d74;
}
.dosecallout .callout .text .callout-green {
  color: #B2D234;
  font-size: 16px!important;
  font-family: "roboto-bold"!important;
  margin-bottom: -2px;
}
.dosecallout.flex_two_three .callout {
  margin-top:18px;
}
.dosecallout.flex_two_three .callout2 .text, .dosecallout.flex_two_three .callout2 .image {
  margin-top:12px;
}
.dosage.doubled-ORR {clear:both;}
.doubled-ORR .container-center h2 {
  margin-bottom:0;
} 
.dosingcallout {margin-top:-12px;}
.dosing-page .doubled-ORR {padding:45px 0 0 0;}
.common-tagging1 a:hover {background-color:#FFA836;}
/* START - Dosing Page - Vertical Scroll Nav */

.dosing-nav .arrows {
  position: relative;
}

.dosing-nav .arrows .arrow-left,
.dosing-nav .arrows .arrow-right {
  position: absolute;
  width: 150px;
  height: 39px;
  pointer-events: none;
  z-index: 1;
}

.dosing-nav .arrows .arrow-right {
  right: 0;
  background-image: linear-gradient(to right, rgba(255, 255, 255, 0) 25%, rgba(255, 255, 255, 1) 75%);
}

.dosing-nav .arrows .arrow-left {
  background-image: linear-gradient(to left, rgba(255, 255, 255, 0) 25%, rgba(255, 255, 255, 1) 75%);
}

.dosing-nav .arrows .arrow-icon {
  position: absolute;
  width: 20px;
  height: 100%;
  cursor: pointer;
  pointer-events: auto;
}

.dosing-nav .arrows .arrow-right .arrow-icon {
  right: 0;
}

.dosing-nav .arrows .arrow-icon:after {
  content: "";
  position: absolute;
  width: 13px;
  height: 13px;
  border-top: 3px solid #000000;
  border-right: 3px solid #000000;
  top: 13px;
  transform: rotate(-135deg);
  left: 3px;
}

.dosing-nav .arrows .arrow-right .arrow-icon:after {
  left: auto;
  right: 3px;
  transform: rotate(45deg);
}

.dosing-nav .arrows .arrow-icon:active,
.dosing-nav .arrows .arrow-icon:hover {
  opacity: .5;
}

.dosing-nav .anchors {
  overflow: hidden;
}

.dosing-nav .anchors ul {
  padding: 0;
  margin: 0;
  display: flex;
  list-style: none;
  left: 0;
  position: relative;
}

.dosing-nav .anchors ul li {
  margin-right: 20px;
}

.dosing-nav .anchors ul li:last-child {
  margin-right: 0;
}

.dosing-nav .anchors ul li span,
.dosing-nav .anchors ul li a {
  display: inline-block;
  padding: 10px 20px;
  color: #000000;
  white-space: nowrap;
  font-size: 16px;
}
.dosing-nav .anchors ul li:nth-child(1) a {padding-left:5px;}

.dosing-nav .anchors ul li:last-child a {
  padding-right: 0;
}

.dosing-nav .anchors ul li:nth-child(1) span {
  font-family: 'Roboto-Medium';
  padding: 0px 0 0px 0;
}
.dosing-nav .anchors ul li:nth-child(2) span{
  opacity:.5;
}

.dosing-nav .anchors ul li:nth-child(1) span:after {
  content: "|";
  margin-left: 40px;
}

.dosing-nav .anchors ul li a {
  font-family: 'Roboto-Regular';
}

.dosing-nav .mCSB_horizontal.mCSB_inside > .mCSB_container {
  margin-bottom: 0;
}

.dosing-nav .mCSB_scrollTools.mCSB_scrollTools_horizontal a + .mCSB_draggerContainer {
  visibility: hidden;
  pointer-events: none;
}

.dosing-nav .mCS-dark-3.mCSB_scrollTools .mCSB_buttonLeft,
.dosing-nav .mCS-dark-3.mCSB_scrollTools .mCSB_buttonRight {
  width: 20px;
  height: 39px;
  margin-top: -23px;
  background: none;
}

.dosing-nav .mCS-dark-3.mCSB_scrollTools .mCSB_buttonLeft.hide-elem,
.dosing-nav .mCS-dark-3.mCSB_scrollTools .mCSB_buttonRight.hide-elem {
  visibility: hidden;
  pointer-events: none;
}


/* END - Dosing Page - Vertical Scroll Nav */

.dose-reduction-body p:first-child,
.dosing-page #maincontent strong,
.dosing-administration-oc #maincontent strong,
.dosing-administration-bc #maincontent strong,
.dosing-page #maincontent h1,
.dosing-page #maincontent h2,
.dosing-page #maincontent h3,
.dosing-page #maincontent h4,
.dosing-administration-oc #maincontent h1,
.dosing-administration-oc #maincontent h2,
.dosing-administration-oc #maincontent h3,
.dosing-administration-oc #maincontent h4,
.dosing-administration-bc #maincontent h1,
.dosing-administration-bc #maincontent h2,
.dosing-administration-bc #maincontent h3,
.dosing-administration-bc #maincontent h4 {
  font-family: "Roboto-Bold";
}

.dosing-page #maincontent h1,
.dosing-administration-oc #maincontent h1,
.dosing-administration-bc #maincontent h1 {
  font-size: 30px;
  line-height: 36px;
}

.dosing-page #maincontent h2,
.dosing-administration-oc #maincontent h2,
.dosing-administration-bc #maincontent h2 {
  font-size: 25px;
  line-height: 32px;
  margin-top: 0;
  padding: 0;
  margin-bottom: 35px;
}

.dosing-page .dosage h2+p {
  /*text-align: center;*/
}

.dosing-page #maincontent h2+center {
  margin-bottom: 20px;
}

.dosing-page #maincontent #neutropenia-block .other-notes h2 {
  font-size: 23px;
}
.dosing-page .common-headline h3 {color:#fff;font-style:italic;font-size:18px;}
.dosing-page #maincontent h3,
.dosing-administration-oc #maincontent h3,
.dosing-administration-bc #maincontent h3 {
  font-size: 20px;
  line-height: 25px;
}

.dosing-page #maincontent p,
.dosing-administration-oc #maincontent p,
.dosing-administration-bc #maincontent p,
.dosing-page #maincontent ul>li,
.dosing-administration-oc #maincontent ul>li,
.dosing-administration-bc #maincontent ul>li {
  font-family: "Roboto-Regular";
  font-size: 16px;
  line-height: 22px;
}

.dosing-page #maincontent .dosing-nav ul>li {
  text-align: center;
}
.dosing-page #maincontent .dosing-nav ul>li.selected a {
  font-family: 'Roboto-Medium';
  /*text-transform: uppercase;*/
  text-decoration:underline;
}
.dosing-page #maincontent .dosing-nav ul>li:nth-child(3) {
  min-width: 101px;
}
.dosing-page #maincontent .dosing-nav ul>li:nth-child(4) {
  min-width: 151px;
}
.dosing-page #maincontent .dosing-nav ul>li:nth-child(5) {
  min-width: 117px;
}
.dosing-page #maincontent .dosing-nav ul>li:nth-child(6) {
  min-width: 125px;
}
.dosing-page #maincontent .dosing-nav ul>li:nth-child(7) {
  min-width: 296px;
}
.dosing-page #maincontent .dosing-nav ul>li:nth-child(8) {
  min-width: 102px;
}
.dosing-page #maincontent .dosing-nav ul>li:nth-child(9) {
  min-width: 123px;
}
.dosing-page #maincontent .dosing-nav ul>li:nth-child(10) {
  min-width: 219px;
}
.dosing-page #maincontent .dosing-nav ul>li:nth-child(11) {
  min-width: 128px;
}

.dosing-page #maincontent p.footnote,
.dosing-page #maincontent .footnote p,
.dosing-administration-oc #maincontent p.footnote,
.dosing-administration-oc #maincontent .footnote p,
.dosing-administration-bc #maincontent p.footnote,
.dosing-administration-bc #maincontent .footnote p {
  font-family: "Roboto-Light";
  font-weight: lighter!important;
  font-size: 14px;
  line-height: 17px;
}
ul#doubled-ORRlist {margin-bottom:0px;}

/*.rec-dosage-body,
.dosing-page .doubled-ORR,
.dosing-administration-oc .doubled-ORR,
.dosing-administration-bc .doubled-ORR,*/
      .clinical-studies.doubled-ORR, .dosing-callouts, .median-time-ar {
  background-color: #e5edf0;
}

.dose-interruption-header h2,
.median-solo-container .solo-header h4,
.median-time-ar h2,
.dosing-page .clinical-studies h2,
.dosing-administration-oc .clinical-studies h2,
.dosing-administration-bc .clinical-studies h2,
.dosing-page .doubled-ORR h2,
.dosing-administration-oc .doubled-ORR h2,
.dosing-administration-bc .doubled-ORR h2 {
  color: #004D74!important;
}

.dosing-administration-bc .common-headline {
  background-color: #5A457A;
}

.scroll-more+p {
  padding-top: 3%;
  padding-bottom: 1%;
}

.dosage h2+p {
  padding-bottom: 1%;
}

.median-time-ar {

  padding-bottom:30px;

}

.median-solo-container .solo-header,
.median-solo-container .solo-body {
  width: 90%;
}

.median-solo-container .solo-body ul {
  padding: 0px;
  list-style: none;
}

.median-solo-container .solo-body ul>li {
  margin-left: 0;
  position: relative;
  padding:0 0 0 2px;
}

.median-solo-container .solo-body ul>li:before {
  content: " ";
  width: 5px;
  height: 5px;
  border-radius: 50%;
  display: inline-block;
  background-color: #000;
  position: absolute;
  left: -10px;
  top: 7px;
}

.median-solo-container>div {
  padding: 0;
  width: 25%;
}

.median-olympiad p.footnote {
  padding-top: 15%;
}


/*********END - COMMON SETTINGS*********************************************************/

.dosage .image-scroll {
  margin-top: -3%;
}


/**********Callouts-start*********************************************************************************/

.dosing-callouts {
  padding: 40px 0;
}
.dosing-administration-global .dosing-callouts {padding:40px 0 25px 0px;}

.rec-dosage {
  display: flex;
}
.dosing-nav {
  position: fixed;
  width: 100%;
  background: #fff;
  z-index: 9;
  margin-top: -36px;
}
.rec-dosage-header {
  background-color: #004D74;
  width: 60%;
  padding: 90px 50px;
  display: flex;
  align-items: center;
}

.rec-dosage-header h2 {
  width: 60%;
  margin: 0 !important;
  color: #FFFFFF;
  font-size: 20px;
  line-height: 22px;
}

.rec-dosage-body {
  padding: 50px 30px;
      background-color: #fff;
}

.rec-dosage {
  margin-top: 10px;
}

.recommended-dosage p,
.dose-interruption p {
  position: relative;
  top: 30%;
}

.dose-interruption-header {
  background-color: #B2D234;
}

.dose-interruption-body {
  padding: 5%!important;
  padding-bottom: 6%!important;
}

.dose-interruption-body img {
  margin: auto;
}

.dose-interruption.rec-dosage .dose-interruption-body a {
  color: #000;
  text-decoration: underline;
}

.dose-interruption.rec-dosage .dose-interruption-body a:hover {
  text-decoration: none;
}

.dose-reduction-header {
  background-color: #838383;
}

.dose-reduction-header h2 {
  width: 80% !important;
}

.dose-img-text-container {
  display: flex;
  /* padding: 1%; */
}
.dose-img-text-container.pad-top {
  padding-top: 1em;
}
.dose-img-text-container .dose-txt p:first-child {
  margin-bottom: 0 !important;
}

.dose-img-text-container .dose-img {
  padding: 5px 10px 5px 0px;
}
img.\31 00mg-pad {
  padding-bottom: 3px;
}
img.\31 00mg-img2 {
  display: block;
}

/*************Callouts-end**************************************************************************************/

.clinical-studies h2 {
  padding-bottom: 2px!important;
}

.clinical-studies center {
  padding-top: 20px;
}

.median-solo-container {
  display: flex;
  padding: 0 1% 1% 1%;
}

.median-solo-container .solo-header {
  background-color: #B2D234;
  padding: 2%;
  text-align: center;
  transform: skewX(-10deg);
}

.median-solo-container .solo-header h4 {
  transform: skewX(10deg);
  margin: 0;
}

.median-solo-container .solo-body {
  padding: 6% 4% 4% 4%;
}

.median-time-ar h2 {
  padding-left: 1%;
}

.median-solo-1 .solo-body {
  padding-top: 14px;
}

.footnote p {
  margin-bottom: 0 !important;
}

.dosing-page .breaking {
  display: inline-block;
}


/********************************dosage block***************************************/

.dosing-page .doubled-ORR,
.dosing-administration-oc .doubled-ORR,
.dosing-administration-bc .doubled-ORR {
  padding: 30px 0 0px 0;
}
.clinical-studies.doubled-ORR {padding:30px 0 20px 0;margin-top:30px;}
.dosing-administration-oc .doubled-ORR.patient{  padding: 30px 0 46px 0;}
.dosing-page .clinical-studies.doubled-ORR.studycli {
  padding: 40px 0 30px 0;
}
.dosing-page.mono .clinical-studies.doubled-ORR.studycli {
  padding: 40px 0 5px 0;
}
.dosing-administration-oc.mono .doubled-ORR.patient{  padding: 30px 0 0px 0;}
.dosing-page .doubled-ORR .footnote {margin-bottom:35px;}
.dosing-page .footnote.dose {margin-top:20px;margin-bottom:0px;}
.dosing-page .footnote.dosing {margin-top:30px;margin-bottom:0px;}
.dosing-page .doubled-ORR ul#doubled-ORRList {padding-bottom:30px;}
.dosing-page .doubled-ORR h2:nth-of-type(2){margin-top:15px!important;}

.dosage.doubled-ORR.patient img.desktop {width:100%;}

/*.dosing-page #maincontent .clinical-studies.doubled-ORR ul li{
  margin-left: 0px;
  padding: 0 0 0 5px;
}*/

.dosing-page .doubled-ORR .inner-wrapper>h2,
.dosing-administration-oc .doubled-ORR .inner-wrapper>h2,
.dosing-administration-bc .doubled-ORR .inner-wrapper>h2 {
  padding-bottom: 3%;
}


/*******************************end dosage block**************************************/


/**********************************************START-AR MANAGEMENT*********************************************************/

.section-block {
  padding: 35px 0;
}

.section-block strong {
  font-size: 16px;
  line-height: 19px;
}

.section-block .section-block-sub-heading {
  font-family: "Roboto-Regular";
  padding-bottom: 35px;
}

.section-block .section-block-heading,
.section-block .section-block-sub-heading {
  color: #004d74;
}

.dosing-administration-bc .section-block .section-block-heading,
.dosing-administration-bc .section-block .section-block-sub-heading {
  color: #5A457A;
}

.section-chart table+table {
  margin-top: 5%;
}

.section-chart .table tr>td,
.table thead tr>th {
  padding: 1% 2%;
  text-align: center;
}

.section-chart .table thead,
.table tfoot th:first-child,
caption {
  background-color: rgba(0, 77, 116, 0.1);
  color: #004d74;
  font-family: "Roboto-Bold";
}

.dosing-administration-bc .section-chart .table thead,
.dosing-administration-bc .table tfoot th:first-child,
.dosing-administration-bc caption {
  background-color: rgba(90, 69, 122, .1);
  color: #5A457A;
}

.dosing-administration-bc .table {
  color: #5A457A;
}

.table tfoot th:first-child {
  padding: 15px 50px;
}

.table tfoot td {
  text-align: left !important;
  padding: 35px 50px !important;
}

caption {
  text-align: center;
  padding: 15px;
  margin-bottom: 2px;
}

.section-block-1 {
  padding-bottom: 35px;
  
}

.dosing-page .section-block-2 {
  border-top: solid 25px #f7941d;
  background-color: #004d74;
  padding-bottom: 50px;
  width: 100%;
  text-align: center;
}

.dosing-page.dosing-administration-bc .section-block-2 {
  background-color: #5A457A;
}

.dosing-page .section-block-2 .management-stategy img {
  margin-top: -25px;
}

.dosing-page .section-block-2 .management-stategy h2 {
  margin-top: 25px !important;
  margin-bottom: 5px !important;
}

.dosing-page .section-block-2 h2 {
  margin: 5px !important;
}

.dosing-page .section-block-2 .inner-wrapper>div {
  padding-bottom: 40px;
  padding-left: 35px;
  padding-right: 35px;
}

.dosing-page .section-block-2 .inner-wrapper>div img {
  width: 45px;
}

.dosing-page .section-block-2 .inner-wrapper>div p {
  margin-bottom: 0;
  padding-left: 0;
}


/*.dosing-page .section-block-2 .inner-wrapper>div ul {
margin: 0;
padding-left: 0;
}
.dosing-page .section-block-2 ul {
list-style: none;
}
.dosing-page .section-block-2 ul li.inner-list:before {
display: none;
}
.dosing-page .section-block-2 ul li:before {
content: "\2022";
font-size: 1.3em;
line-height:12px;
margin-right: 7px;
vertical-align:middle;
}
.dosing-page .section-block-2 ul ul>li:before {
content: "-";
}
.dosing-page .section-block-2 ul ul>li {
font-size: 0.9em !important;
}
.dosing-page .section-block-2 .inner-wrapper>div ul.dot {
margin-bottom: 10px;
}*/

.dosing-page .section-block-2 .inner-wrapper>div.symptoms-instructions {
  padding-left: 0;
  padding-right: 0;
}

.dosing-page .section-block-2 .symptoms-insruction-header {
  background-color: #f7941d;
  width: 100%;
  text-align: center;
  color: #FFFFFF;
  padding: 5px 0;
}

.dosing-page .section-block-2 .symptoms-instructions-body {
  padding: 0 33px;
  display: flex;
  flex-wrap: wrap;
}

.dosing-page .section-block-2 .symptoms-instructions-body>div {
  width: calc(50% - 18px);
  padding: 0 15px;
  border-top: 1px solid #f7941d;
  text-align: center;
  margin-top: 57px;
}

.dosing-page .section-block-2 .symptoms-instructions-body>div:nth-child(even) {
  margin-left: 35px;
}

.dosing-page .section-block-2 .symptoms-instructions-body>div:before {
  content: "";
  width: 45px;
  height: 45px;
  margin-top: -22px;
  margin-bottom: 5px;
  background-size: 100%;
  display: inline-block;
}

.dosing-page .section-block-2 .symptoms-instructions-body>div p:first-child {
  margin-bottom: 10px;
}

.dosing-page .section-block-2 .symptoms-instructions-body>div.instruction-1::before {
  background-image: url(/content/dam/physician-services/us/590-lynparza-hcp-branded/dosing-ar/circle1-2x.png);
}

.dosing-page .section-block-2 .symptoms-instructions-body>div.instruction-2::before {
  background-image: url(/content/dam/physician-services/us/590-lynparza-hcp-branded/dosing-ar/circle2-2x.png);
}

.dosing-page .section-block-2 .symptoms-instructions-body>div.instruction-3::before {
  background-image: url(/content/dam/physician-services/us/590-lynparza-hcp-branded/dosing-ar/circle3-2x.png);
}

.dosing-page .section-block-2 .symptoms-instructions-body>div.instruction-4::before {
  background-image: url(/content/dam/physician-services/us/590-lynparza-hcp-branded/dosing-ar/circle4-2x.png);
}

.dosing-page .section-block-2 .symptoms-instructions-body>div img {
  margin-top: 15px;
  width: 80%;
}

.dosing-page .section-block-2 .symptoms-instructions-body>div p:first-child+img {
  margin-top: 0;
}

.dosing-page .section-block-2 .symptoms-instructions-body>div>ul {
  margin-top: 10px;
}

.dosing-page .section-block-2 .symptoms-instructions-body>div ul ul>li {
  font-size: 0.9em !important;
}

/*.dosing-page .section-block-2 .symptoms-instructions-body>div ul ul>li:before {
  content: "-";
}*/

.dosing-page .section-block-2 .section-foot {
  text-align: left;
  padding-top: 50px;
  padding-bottom: 0 !important;
}

.dosing-page .section-block-2 .section-foot h2 {
  margin: 15px 0 0 0 !important;
}

.dosing-page .section-block-2 .section-foot h3 {
  margin: 15px 0 0 0 !important;
}

.dosing-page .section-block-2 .section-foot p {
  margin: 10px 0 0 0;
}

.dosing-page .section-block-2 .section-foot .action-cta {
  text-align: center;
  padding-top: 30px;
}

.dosing-page .section-block-2 .section-foot .action-cta>div {
  width: 40%;
  display: inline-block;
}

.dosing-page .section-block-2 .section-foot .action-cta>div:nth-child(1) {
  margin-right: 4%;
}

.dosing-page .section-block-2 .section-foot .action-cta>div:nth-child(2) {
  margin-left: 4%;
}

.dosing-page .section-block-2 .section-foot .action-cta>div a {
  display: flex;
  flex-wrap: wrap;
  text-align: center;
  width: 95%;
  border: 2px solid #bbbbcc;
  border-radius: 10px;
  padding: 12px 0;
  display: inline-block;
  text-decoration: none;
}

.dosing-page .section-block-2 .section-foot .action-cta>div a:hover {
  background-color: rgba(255, 255, 255, .2);
}

.dosing-page .section-block-2 .inner-wrapper>div.symptoms-instructions-other {
  text-align: left;
  padding-bottom: 25px;
}

.dosing-page .section-block-2 .inner-wrapper>div.symptoms-instructions-other p {
  padding-bottom: 7px;
  border-bottom: 1px solid #f7941d;
  margin: 0;
  font-family: 'Roboto-Bold' !important;
}

.dosing-page .neutropenia-block-1 .other-notes {
  padding-left: 35px;
  padding-right: 35px;
}

.dosing-page .neutropenia-block-1 .other-notes h2 {
  margin-bottom: 10px !important;
  padding-bottom: 10px !important;
}

.dosing-page #maincontent .dosing-nav ul:first-child li {
  padding: 0;
}


.dosing-page #maincontent ul#doubled-ORRList li{ 
  margin-left: 0px;
  padding: 0 0 0 0px;
}
/*.dosing-page .section-block-2 ul:last-child li:before{ margin-left: -15px; }*/

.dosing-page .indent-1,
.dosing-page .indent-2 {
  display: inline-block;
}

.dosing-page #neutropenia-block .symptoms-instructions-other h2 {
  margin: 0 0 5px 0 !important;
  padding: 0 0 5px 0;
}

.dosing-page #neutropenia-block .symptoms-instructions-other h2+p {
  border: none;
}

#neutropenia-block ul, 
#nausea-block ul, 
#headache-block ul, 
#fatigue-block ul, 
#dyspepsia-block ul, 
#dysgeusia-block ul, 
#diarrhea-block ul, 
#constipation-block ul, 
#anemia-block ul
{
text-align: left;
  padding: 0;
  margin: 0;
  list-style: none;
}
#neutropenia-block ul li, 
#nausea-block ul li, 
#headache-block ul li, 
#fatigue-block ul li, 
#dyspepsia-block ul li, 
#dysgeusia-block ul li, 
#diarrhea-block ul li, 
#constipation-block ul li, 
#anemia-block ul li {
margin: 0;
  padding: 5px 0 0 20px;
}
#anemia-block ul li ul.dash li{
  padding: 0 0 0 13px;
}
#neutropenia-block ul li::before, 
#nausea-block ul li::before, 
#headache-block ul li::before, 
#fatigue-block ul li::before, 
#dyspepsia-block ul li::before, 
#dysgeusia-block ul li::before, 
#diarrhea-block ul li::before, 
#constipation-block ul li::before, 
#anemia-block ul li::before {
  content: "•";
  font-size: 1.3em;
  line-height: 12px;
  margin-left: -15px;
  margin-right: 7px;
  vertical-align: middle;
}
#neutropenia-block ul li ul.dash li::before, 
#nausea-block ul li ul.dash li::before, 
#headache-block ul li ul.dash li::before, 
#fatigue-block ul li ul.dash li::before, 
#dyspepsia-block ul li ul.dash li::before, 
#dysgeusia-block ul li ul.dash li::before, 
#diarrhea-block ul li ul.dash li::before, 
#constipation-block ul li ul.dash li::before, 
#anemia-block ul li ul.dash li::before{
  content: "-";
  margin-left: -20px;
  margin-right: 8px;
}
#anemia-block ul li ul.dash li::before {
  margin-left: -12px;
  margin-right: 7px;
}
#nausea-block .nausea-block-2.section-block-2 .consider-prescribing .floatRight ul{
  padding-bottom: 15px;
}
/*#anemia-block .anemia-block-2.section-block-2 .symptoms-instructions .instruction-4 ul li ul.dash li{
  padding: 0 0 0 14px;
}
.dosing-page #neutropenia-block .symptoms-instructions-other ul {
padding-left: 40px;
list-style-position: outside;
}
.dosing-page #neutropenia-block .symptoms-instructions-other ul li:before {
display: inline-block;
  margin-right: 13px;
  margin-left: -20px;
}*/

.dosing-page .indent-1 {
  text-indent: -6px;
}

.dosing-page .indent-2 {
  text-indent: -11px;
}


/*.section-block-2 ul>li {
padding-top: 5px;
}*/

.management-stategy,
.clinical-evaluation,
.patient-counselling,
.consider-prescribing,
.advise-patients-to,
.assess-cause {
  color: #FFFFFF;
}


/*.section-block-2 ul:last-child {
padding: 0;
margin: 0;
}*/

hr {
  border-top: 1px solid #f7941d;
  margin: 7px 0;
}

.consider-prescribing hr {
  border-top: 1px solid #b2d235;
}

.symptoms-instructions,
.symptoms-instructions-other {
  background-color: #FFFFFF;
}

.symptoms-insruction-header h2 {
  padding: 10px;
}

.section-block .footnote,
.ssi,
.section-block a {
  color: #FFFFFF!important;
}

.show-isi {
  padding-top: 15px;
}

.show-isi a {
  text-decoration: underline;
  /*font-family: "Roboto-Bold";*/
  /*SIT*/
}

.symptoms-instructions-other {
  padding: 25px 40px;
  color: #6e6a6a;
}

.neutropenia-block-2 .symptoms-instructions-other {
  margin-top: 4%!important;
  max-width: calc(100% - 70px);
  margin: auto;
}

.neutropenia-block-2 .symptoms-instructions-other h2 {
  border-bottom: solid 1px #f7941d;
}

.neutropenia-block-2 .symptoms-instructions-other ul {
  /* list-style-position: outside; */
  padding-left: 5%;
}

.other-notes h2 {
  padding-bottom: 1%;
  border-bottom: 1px solid #b2d235;
}

.other-notes {
  padding: 20px 0;
}

.other-notes h2+p {
  padding-top: 1%;
}

.section-block .other-notes .footnote {
  color: #000000!important;
}


/**SIT**/

.neutropenia-block-1 .other-notes h2 {
  line-height: 35px!important;
}

.neutropenia-block-2 .clinical-evaluation:nth-child(3) hr,
.neutropenia-block-2 .patient-counselling hr {
  border-color: #b2d235;
}

.table td:nth-child(1) {
  width: 20%;
}

.link-text {
  word-break: break-word;
}
.text-break-all {
word-break: break-all;
}
.common-tagging1{
padding-top: 30px;
  text-align: center;
}
.common-tagging1.small-common-tag {
padding-top: 10px;
}
.common-tagging1 a{
  display: inline-block;
width: 86%;
  padding-top: 10px;
  padding-bottom: 10px;
  color: #ffffff;
  text-decoration: none;
  font-family: 'Roboto-Bold';
  font-size: 20px;
  line-height: 25px;
  transform: skewX(-10deg);
  background-color: #f7941f;
  border: solid 3px #f7941f;
  max-width: 100%;
}
.AR-disclaimer {margin-top:20px;text-align:center;}
.AR-disclaimer p a {color:#fff;}
.AR-disclaimer p a:hover {text-decoration:underline;}
.AR-disclaimer p{
  color: #ffffff!important;
  line-height: 25px;
      max-width: 100%;
      transform:skewX(10deg);
  }
  .dosing-page .AR.doubled-ORR {
      padding: 50px 0 0px 0;

  }
.AR-disclaimer{
  display: block;
  width: 90%;
  padding-top: 20px;
  padding-bottom: 20px;
  margin:0 auto;
  text-decoration: none;

  background-color: #004d74;
  /* border: solid 3px #f7941f; */

  padding-left: 60px;
  padding-right: 45px;
  text-align:left;
  font-style:italic;
}
.AR-disclaimer {transform: skewX(-10deg);width:85%;}
.common-tagging1.small-common-tag a span {
transform: skewX(10deg);
  display: inline-block;
}
.AR-disclaimer.CR {width:75%; margin:30px auto 0px 80px;}

.common-tagging1.small-common-tag a {
width: 70%;
  margin-left:-40px;
}
.common-tagging1.small-common-tag.monotag .arrow-icon {
right:20%!important;
                      top:58%;
                      width:18px;
                      height:18px;
}
.common-tagging1.small-common-tag .arrow-icon {
right:21%!important;
}
.common-tagging1 .arrow-icon{
  content: "";
  position: absolute;
  width: 13px;
  height: 13px;
  border-top: 3px solid #ffffff;
  border-right: 3px solid #ffffff;
  right:18%;
  transform: rotate(45deg);
  top: -32px;
}
.common-tagging1 {position:relative;}



/**SIT**/


/**********************************************END-AR MANAGEMENT*********************************************************/


/**********************************************END-GLOBAL SETTINGS***********************************************************************/


/*********************************************START- max-width 1023px ******************************************************************/

@media (max-width: 1023px) {
  .mobile {
      display: block;
  }
  .desktop {
      display: none;
  }
.nowrap.desk{white-space:normal;}
  .dosing-page #maincontent h1,
  .dosing-administration-oc #maincontent h1,
  .dosing-administration-bc #maincontent h1 {
      font-size: 20px;
      font-style: italic;
      line-height: 25px;
  }
  .dosing-page #maincontent h2,
  .dosing-administration-oc #maincontent h2,
  .dosing-administration-bc #maincontent h2 {
      font-size: 18px;
      line-height: 22px;
  }
.dosing-page .common-headline h3{font-size:18px!important;}
  .dosing-page #maincontent h3,
  .dosing-administration-oc #maincontent h3,
  .dosing-administration-bc #maincontent h3 {
      font-size: 15px;
      line-height: 18px;
  }
  .dosing-page #maincontent sup,
  .dosing-administration-oc #maincontent sup,
  .dosing-administration-bc #maincontent sup {
      font-weight: lighter!important;
      line-height: 12px!important;
      /*font-family: "Roboto-Medium"!important;*/
  }
#administration-block > div > h1 > sup {
  top: -15px;
}
  .dosing-page #maincontent .neutropenia-block-1 .footnote sup {
      font-family: "Roboto-Light"!important;
  }
  .dosing-page #maincontent p.footnote,
  .dosing-page #maincontent .footnote p,
  .dosing-administration-oc #maincontent p.footnote,
  .dosing-administration-oc #maincontent .footnote p,
  .dosing-administration-bc #maincontent p.footnote,
  .dosing-administration-bc #maincontent .footnote p {
      font-size: 10px!important;
      line-height: 12px!important;
  }
  .dosing-page .dosage h2+p {
      text-align: left;
  }
  /******************************************START- DOSING AND MANAGEMENT *********************************************/
  .dosing-callouts {
      padding: 40px 0 30px 0;
  }
  .rec-dosage {
      flex-direction: column;
      margin-top: 30px;
  }
  .rec-dosage-header {
      transform: skewX(-10deg);
      text-align: center;
      margin-bottom: 5px;
      padding: 0;
      width: 100%;
  }
  .rec-dosage-header h2 {
      transform: skewX(10deg);
      margin: 0 !important;
      padding: 5px !important;
      width: 100%
  }
  .dose-reduction-header h2 {
      width: 100% !important;
  }
  .rec-dosage-body {
      padding: 20px;
  }
  .dose-interruption-body {
      padding: 20px !important;
  }
  .rec-dosage-body img {
      width: 100%;
  }
img.\31 00mg-pad {
  padding-bottom: 2px;
}

  .recommended-dosage p,
  .dose-interruption p {
      padding-top: 45px;
  }
  .dose-interruption {
      flex-direction: column-reverse;
  }
  .dose-interruption p:nth-child(4) {
      padding-top: 1%;
  }
  .dose-img-text-container {
      flex-direction: row-reverse;
  }
  .dose-img-text-container .dose-img {
      width: 20%;
  }
  .dose-img-text-container .dose-txt {
      width: 80%;
  }
  .dose-reduction-body {
      /*background-color: #f1f1f1;*/
  }
  .clinical-studies h2+p {
      width: 100%;
  }
  .median-time-ar {
      padding: 0px 0 30px 0;
  }
  .median-solo-container .solo-header {
      padding: 5px;
  }
  .median-solo-container {
      flex-direction: column;
  }
  .median-solo-container>div,
  .median-solo-container .solo-header,
  .median-solo-container .solo-body {
      width: 100%;
  }
  .median-solo-container .solo-body {
      padding: 10px 25px 20px;
  }
  .median-solo-container>div:first-child {
      padding: 0;
      width: 100%;
  }
  .median-olympiad p.footnote {
      padding: 5px 0 0 0;
  }
  table.table thead tr th {
      padding: 10px;
      text-align: center !important;
  }
  table.table thead tr th:first-child {
      text-align: left;
  }
  table.table td {
      padding: 10px;
  }
  .table tfoot th:first-child {
      padding: 10px;
  }
  .table tfoot td {
      text-align: left !important;
      padding: 10px !important;
  }
  .dosage>*,
  .dosing-header>*,
  .clinical-studies>* {
      /* width: 90%; */
      margin: auto 20px;
  }
  /****** scroll bar settings starts here **********/
  .scroll-more.mobile p {
      padding-top: 0%!important;
      font-style: italic;
  width:100%!important;
  }
  /*.image-scroll img {padding-bottom:4%;}8/

/****** scroll bar settings starts here **********/
  .image-scroll {
      overflow-x: auto;
      white-space: nowrap;
      max-width: 100%;
      scroll-behavior: smooth;
  }
  .image-scroll::-webkit-scrollbar-track {
      background: #ddd;
  }
  .image-scroll::-webkit-scrollbar {
      width: 1px;
  }
  .image-scroll::-webkit-scrollbar-thumb {
      background: #004D74;
  }
  /******* scroll bar settings ends here *************/
  /**************** recent-changes*****************/
  .dosage {
      padding: 0;
  }
  .dose-interruption-header h2 {
      color: #FFFFFF;
  }
  .clinical-studies {
      padding-top: 0;
  }
  /*.clinical-studies .image-scroll img {width: 176%;}*/
  /*******************************************************/
  /******************END- DOSING AND MANAGEMENT ********************************************************/
  /*********************START- AR MANAGEMENT******************************************************/
  /* .section-block-2 ul {
      list-style-position: outside;
  }*/
  .clinical-evaluation h2,
  .patient-counselling h2,
  .consider-prescribing h2,
  .advise-patients-to h2,
  .assess-cause h2 {
      margin-bottom: -15px;
  }
  .clinical-evaluation,
  .patient-counselling,
  .consider-prescribing,
  .advise-patients-to,
  .assess-cause {
      padding-left: 30px;
  }
  .symptoms-insruction-header {
      background-color: #FFFFFF;
      width: 100%;
      padding: 5px 20px;
  }
  .symptoms-insruction-header h2 {
      border-bottom: 1px solid #f7941d;
  }
  .symptoms-instructions-body {
      padding: 0 35px;
  }
  .symptoms-instructions-body {
      flex-direction: column;
  }
  .symptoms-instructions-body>div {
      width: 100% !important;
      padding: 0
  }
  .dosing-page .section-block-2 .symptoms-instructions-body>div:nth-child(even) {
      margin-left: 0;
  }
  .instruction-1 p,
  .instruction-2 p,
  .instruction-3 p,
  .instruction-4 p {
      margin: 0;
      padding: 0;
  }
  /**************recent changes****************/
  .anemia-block-1 {
      padding-top: 0;
  }
  .section-block {
      padding: 0;
  }
  .section-block-1 {
      padding: 50px 0 35px 0;
  }
  /*********************************************/
  .dosing-page .section-block-2 .section-foot .action-cta>div {
      width: 44%;
  }
    .common-tagging1 .arrow-icon {
    right:18%;
    top: -40px!important;
  }
.common-tagging1.small-common-tag .arrow-icon {
    right:18%!important;
    top: 58%!important;

  }
.common-tagging1.small-common-tag.monotag .arrow-icon{top:50%!important}
.common-tagging1.small-common-tag.monotag {margin-top:30px;}
.combi .common-tagging1.small-common-tag .arrow-icon {
    right:20%!important;
    top: 50%!important;

  }



  /* START - Dosing Page - Vertical Scroll Nav */
  .dosing-nav .container-center {
      padding-left: 10px;
      padding-right: 10px;
  }
  /* END - Dosing Page - Vertical Scroll Nav */
}

@media (max-width: 767px) {
.dosing-page .section-block-2 .section-foot p {
  margin: 0;
}

.nowrap.ipa{white-space:normal;}

.dosing-page .common-headline h3 {font-size:16px;}
  /*.dosing-page #maincontent ul:last-child li {
      margin-left: 0px;
      padding: 5px 0 0 15px;
  }*/
  .dosing-page .section-block-2 .inner-wrapper .floatLeft {
      margin: 5px 0 5px 0;
  }
  .dosing-page .section-block-2 .inner-wrapper .floatRight {
      margin: 0 0 20px 0;
  }
#nausea-block .nausea-block-2.section-block-2 .consider-prescribing .floatRight ul {
      padding-bottom: 10px;
  }
#nausea-block .nausea-block-2.section-block-2 .consider-prescribing .floatRight {
      margin: 0;
  }
  .dosing-page .section-block-2 .inner-wrapper>div p,
  /*.dosing-page .section-block-2 .inner-wrapper>div ul {
      margin: 0 auto;
      padding-left: 0;
  }*/
  .mobile {
      display: block;
  }
  .desktop {
      display: none;
  }
  .dosing-page #maincontent p.tablets-size {
      font-size: 12px;
  }
  .instruction-4 ul.dash {
      text-align: left;
      width: 84%;
  }
  .dosing-page .tablets-size {
      padding-top: 20px;
  }
  .dosing-page .section-block-2 .section-foot .action-cta>div:nth-child(2) {
      margin-left: 0%;
  }
  .dosing-page .breaking {
      display: inline-block;
  }
  .dosing-page .footnote {
      padding-top: 25px;
    margin-left: 14px;
  }
  .dosing-page .footnote.adver {
      padding-top: 10px;
  }
  .dosing-page .section-block-2 .section-foot .action-cta>div {
      width: 100%;
  }




.dosing-page .footnote.dosing {margin-top:5px;}
  /* START - Dosing Page - Vertical Scroll Nav */
  .dosing-nav .arrows .arrow-icon:after {
      width: 11px;
      height: 11px;
      border-top: 2px solid #000000;
      border-right: 2px solid #000000;
      top: 13px;
  }
  .dosing-nav .arrows .arrow-left,
  .dosing-nav .arrows .arrow-right {
      width: 100px;
      height: 35px;
  }
  .dosing-nav .anchors ul li {
      margin-right: 10px;
  }
  .dosing-nav .anchors ul li span:after {
      margin-left: 24px;
  }
  .dosing-nav .anchors ul li span,
  .dosing-nav .anchors ul li a {
      font-size: 13px;
      /*padding: 10px;*/
  }
.dosing-nav .anchors ul li:nth-child(1) a {padding-left:0px;}
  /* END - Dosing Page - Vertical Scroll Nav */
  table.table thead tr th {
      padding-left: 5px;
      padding-right: 5px;
      vertical-align: middle;
      text-align: center !important;
  }
  table.table thead tr th {
      padding-left: 5px;
      padding-right: 5px;
      vertical-align: middle;
  }
  .dosing-page #maincontent p,
  .dosing-administration-oc #maincontent p,
  .dosing-administration-bc #maincontent p,
  .dosing-page #maincontent ul>li,
  .dosing-administration-oc #maincontent ul>li,
  .dosing-administration-bc #maincontent ul>li {
      font-size: 13px;
      line-height: 16px;
  }
.recomended-dose-txt.The-recommended p {
  font-size: 16px!important;
  line-height: 20px!important;
}

.dosing-page #maincontent .dosing-nav ul>li:nth-child(3) {
      min-width: 70px;
  }
  .dosing-page #maincontent .dosing-nav ul>li:nth-child(4) {
      min-width: 111px;
  }
  .dosing-page #maincontent .dosing-nav ul>li:nth-child(5) {
      min-width: 83px;
  }
  .dosing-page #maincontent .dosing-nav ul>li:nth-child(6) {
      min-width: 89px;
  }
  .dosing-page #maincontent .dosing-nav ul>li:nth-child(7) {
  min-width: 228px;
  }
  .dosing-page #maincontent .dosing-nav ul>li:nth-child(8) {
      min-width: 71px;
  }
  .dosing-page #maincontent .dosing-nav ul>li:nth-child(9) {
      min-width: 88px;
  }
  .dosing-page #maincontent .dosing-nav ul>li:nth-child(10) {
      min-width: 165px;
  }
  .dosing-page #maincontent .dosing-nav ul>li:nth-child(11) {
      min-width: 98px;
  }
.dosecallout .callout p {line-height:19px!important;}
  #anemia-block ul li ul.dash li {
      padding: 0 0 0 10px;
  }
#dysgeusia-block ul li ul.dash li, #fatigue-block ul li ul.dash li, #nausea-block ul li ul.dash li {
  padding: 0 0 0 13px;
}
  .dosing-page .section-block-sub-heading,
  .dosing-page #maincontent h2 {
      margin-left: 0 !important;
  }
  .dosage .image-scroll {
      margin-top: 0;
  }
  .dosage>*,
  .dosing-header>*,
  .clinical-studies>*,
  .median-time-ar h2,
  .dosage h2+p,
  .dosage .scroll-more+p {
      width: auto;
      margin: auto 0;
  }
  .dose-img-text-container .dose-img {
      min-width: 101px;
  }
  .section-block-1 {
      padding-bottom: 0;
      padding-top: 15px;
  }
  .section-block-2 .inner-wrapper>div.symptoms-instructions-other p {
      font-family: 'Roboto-Bold' !important;
  }
  .symptoms-instructions-other {
      padding: 15px;
  }
  .section-block .management-stategy {
      padding-left: 0 !important;
      padding-right: 0 !important;
      text-align: center;
  }
  .section-block .management-stategy h2,
  .section-block .management-stategy p {
      text-align: left;
  }
  hr {
      margin: 0px 0 5px 0;
  }
  .neutropenia-block-2 .symptoms-instructions-other {
      max-width: calc(100% - 50px);
  }
  #neutropenia-block .section-block-2 .inner-wrapper>div.symptoms-instructions-other p {
      margin-top: 5px;
  }
  .dosing-page #maincontent #neutropenia-block .other-notes h2 {
      font-size: 18px;
      line-height: 22px !important;
  }
  .dosing-page #maincontent h2+center {
      margin-bottom: 10px;
  }
  .dosing-page .common-headline .container-center {
      /* padding-left: 16px; */
  }
  .dosing-page .doubled-ORR {
      padding: 25px 0 0px 0;

  }
.dosing-page .clinical-studies.doubled-ORR {
      padding: 25px 0 20px 0;

  }
          .dosing-page .AR.doubled-ORR {
      padding: 40px 0 0px 0;

  }
  .dosing-page .clinical-s.doubled-ORR {
      padding: 25px 0 30px 0;

  }

  .dosing-page .scroll-more.mobile {
      font-size: 10px;
  }
  .dosing-page #doubled-ORRList {
      margin: 20px 0 0 0;
  }
  .dosing-page .scroll-more.mobile p {
      margin-bottom: 0;
  }
  .dosing-page .rec-dosage-body {
      padding: 7% 6%;
  }
  .dosing-page .dose-img-text-container {
      padding: 1% 0 1% 0;
  }
  .dosing-page .median-solo-container .solo-body {
      padding: 6% 4% 4% 5%;
  }
  /*.dosing-page .median-solo-container .solo-body ul{padding-left:10px;}*/
  .dosing-page #maincontent h2.section-block-heading {
      margin-top: 15px;
      margin-bottom: 24px;
  }
  .dosing-page .table {
      font-size: 13px;
  }
  .dosing-page .section-block-sub-heading {
      margin-left: 18px;
  }
  .dosing-page .table>thead:first-child>tr:first-child>th {
      padding-top: 15px;
  }
  .dosing-page .table tfoot th:first-child {
      padding-left: 5px;
      padding-right: 5px;
      text-align: center;
  }
  .dosing-page .table tfoot td {
      padding: 15px !important;
  }
  .dosing-page .section-block-2 {
      position: relative;
      padding: 0 20px 35px 20px;
  }
  .dosing-page .section-block-2 .inner-wrapper {
      /*padding-left: 0;
  padding-right: 0;*/
      text-align: left;
      padding-left: 0;
      padding-right: 0;
  }
  .dosing-page .section-block-2 .inner-wrapper>div {
      padding: 0 20px 40px 60px;
  }
  /*.dosing-page .section-block-2 .inner-wrapper>div ul li {
      padding-left: 22px;
  }*/
  .dosing-page .section-block-2 .inner-wrapper .symptoms-instructions-other ul li {
      text-indent: 0;
      padding-left: 0;
  }
  /*.dosing-page .section-block-2 .inner-wrapper>div ul li:before {
      margin-right: 10px;
  }*/
#neutropenia-block ul li::before, 
#nausea-block ul li::before, 
#headache-block ul li::before,
#fatigue-block ul li::before, 
#dyspepsia-block ul li::before, 
#dysgeusia-block ul li::before, 
#diarrhea-block ul li::before, 
#constipation-block ul li::before, 
#anemia-block ul li::before {
      margin-left: -13px;
  }
#neutropenia-block ul li ul.dash li::before, 
#nausea-block ul li ul.dash li::before, 
#headache-block ul li ul.dash li::before, 
#fatigue-block ul li ul.dash li::before, 
#dyspepsia-block ul li ul.dash li::before, 
#dysgeusia-block ul li ul.dash li::before, 
#diarrhea-block ul li ul.dash li::before, 
#constipation-block ul li ul.dash li::before, 
#anemia-block ul li ul.dash li::before {
      margin-left: -13px;
  }
#anemia-block ul li ul.dash li::before{
    margin-left: -9px;
    margin-right: 5px;
}
  .dosing-page .section-block-2 .inner-wrapper>div.symptoms-instructions {
      margin-left: 20px;
      /*margin-right: -20px;*/
      text-align: left;
  }
  .dosing-page .section-block-2 .inner-wrapper>div.symptoms-instructions h2 {
      padding-left: 20px !important;
      text-align: left;
  }
  .dosing-page .section-block-2 .inner-wrapper>div.symptoms-instructions .symptoms-instructions-body>div {
      margin-top: 35px;
      border: none;
      text-align: left;
      padding: 0 0 0 5px;
  }
  .dosing-page .section-block-2 .inner-wrapper>div.symptoms-instructions .symptoms-instructions-body>div:before {
      top: 10px;
  }
  .dosing-page .section-block-2 .symptoms-instructions-body>div img {
      margin-left: 10%;
  }
  .dosing-page .section-block-2 .inner-wrapper>div.section-foot {
      padding: 20px 0 0 0;
  }
  .dosing-page .section-block-2 .inner-wrapper>div.section-foot .action-cta {
      padding-top: 20px;
      padding-bottom: 10px;
  }
  .dosing-page .section-block-2 .section-foot .action-cta>div {
      height: 100%;
      vertical-align: top;
      text-align: center;
  }
  .dosing-page .section-block-2 .section-foot .action-cta>div a {
      height: 33px;
      display: flex;
      padding: 0 5px;
      align-items: center;
      align-content: center;
      line-height: 16px;
      justify-content: center;
  }
  .dosing-page .section-block-2 .inner-wrapper>div.symptoms-instructions-other {
      padding: 15px;
      margin-left: 43px;
      max-width: 77%;
  }
  .dosing-page .neutropenia-block-1 .other-notes {
      padding-left: 0;
      padding-right: 0;
  }
  /*.dosing-page .section-block-2 ul {
      list-style-position: outside;
      padding-left: 15px;
  }*/
  .clinical-evaluation,
  .patient-counselling,
  .consider-prescribing,
  .advise-patients-to,
  .assess-cause {
      padding-left: 16px;
      position: relative;
      padding-top: 25px;
  }
  .clinical-evaluation img,
  .patient-counselling img,
  .consider-prescribing img,
  .advise-patients-to img,
  .assess-cause img {
      position: absolute;
      top: 0;
      left: 0;
      margin: auto;
      width: 45px;
  }
  .consider-prescribing {
      padding-bottom: 30px;
  }
  .dosing-page .management-stategy p {
      margin-bottom: 0
  }
  .symptoms-insruction-header {
      padding: 5px 18px;
  }
  .instruction-1::before,
  .instruction-2::before,
  .instruction-3::before,
  .instruction-4::before {
      width: 40px;
      height: 40px;
      position: absolute;
      top: 22px;
      left: -55px;
  }
  .symptoms-instructions-body>div {
      width: 100%;
      position: relative;
      padding-top: 26px;
  }
  .symptoms-instructions-body {
      padding: 0 35px 15px 35px;
  }
  .action-cta>div {
      padding: 5px 0 5px 10px;
  }
  .action-cta>div a {
      font-size: 13px;
  }
  .action-cta>div:last-child {
      margin-left: 0%;
  }
  .dosing-page #maincontent h2.section-block-heading {
      margin-top: 15px;
      margin-bottom: 15px !important;
  }
  .ssi {
      padding-top: 20px;
  }
  .section-block .section-block-sub-heading {
      padding-bottom: 22px;
  }
  .neutropenia-block-1.section-block-1 {
      padding-bottom: 0px;
  }
  .neutropenia-block-2.section-block-2 .patient-counselling {
      padding-bottom: 20px;
  }
  .neutropenia-block-2.section-block-2 .symptoms-instructions-body {
      margin-bottom: 46px;
  }
  .dosing-page .image-scroll .image-scroll-inner {
      width:835px;
      height: 345px;
  }
.dosing-page .image-scroll .image-scroll-inner img {margin-left:-30px;}
.dosing-page .doubled-ORR.patient .image-scroll .image-scroll-inner img {margin-left:0px;}
  .dosing-page .clinical-studies.doubled-ORR .image-scroll .image-scroll-inner {
      width: 835px;
          height: 450px;
  }
  .dosing-page .mCSB_horizontal.mCSB_inside > .mCSB_container {
      margin-bottom: 0px;
  }
  .dosing-page #maincontent .dosage.doubled-ORR h2 {
      margin-left: 0px;
  }
  .dosing-page #maincontent h2,
  .dosing-administration-oc #maincontent h2,
  .dosing-administration-bc #maincontent h2 {
      margin-bottom: 15px;
  }
  .dosing-page .indent-1 {
      text-indent: -4px;
  }
.dosecallout .heading h3::before {
  left:-5px;
  padding-top:12px;
}
.combination-therapy .dosing-callouts .callout-block ul li:nth-child(2) {margin-top:5px;margin-left:10px;}
.dosecallout .callout .image img {margin-left:15px;}
.common-tagging1 .arrow-icon{
  right:18%;
  top: -51px !important;
  width: 18px;
  height: 18px;
  transform: rotate(38deg);

}
.common-tagging1 a {
  font-size:16px;
  width: 71%;
}
    .PAOLA-1 #maincontent .callout-block p {
  font-size:15px !important;
  }
.common-tagging1 {
  padding-top: 10px;
  text-align: center;
  width: 90%;
margin-top: 30px;
color: #ffffff;
  text-decoration: none;
transform: skewX(-10deg);
  background-color: #f7941f;
  border: solid 3px #f7941f;

}
.common-tagging1.monotag {width:90%;margin-left:5px;}
.common-tagging1 a{
transform: skewX(+10deg);
  margin-top:-11px;
}
.common-tagging1.small-common-tag a{width:82%;padding:12px 6px 12px 6px;border:0;}
.common-tagging1:hover {background-color:#FFA836;}
.AR-disclaimer  {

     padding-left:20px;
     padding-right:0px;


}
  .AR-disclaimer p {font-size:16px!important;}
.AR-disclaimer.CR p {}
.AR-disclaimer.CR {width:90%;margin-left:15px;padding-left:25px;padding-right:20px;}
.AR-disclaimer {transform: skewX(-10deg);}
.AR-disclaimer p span {display:inline-block;max-width:96%;}
.common-tagging1.small-common-tag.monotag .arrow-icon {top:40%!important;right:7%!important}
}

@media only screen and (min-width: 1024px) {
  .dosing-page #maincontent p.tablets-size {
     font-size: 14px;
  }
  .floatLeft,.floatRight  {
     float: left;
     width: 50%;
     padding: 0 80px;
  }
.section-block .footnote.toremove p {
  margin-top: 0px;
}
.container-center .col-xs-12 {
  padding-left:0px;
  padding-right:0px;
}
.olaparib-patient-support .container-center .col-xs-12:nth-child(1) {padding-right:15px;padding-left:0;}
.olaparib-patient-support .container-center .col-xs-12:nth-child(2) {padding-left:15px;padding-right:0;}
.combination-therapy .dosing-callouts .callout-block p {font-size:22px!important;}
.combination-therapy .dosing-callouts .callout-block ul li {font-size:22px!important;line-height:28px!important;}
.common-tagging1 .arrow-icon {right:18%!important;}
.common-tagging1.small-common-tag.monotag .arrow-icon {right:16.5%!important;}
.common-tagging1.small-common-tag.monotag a {
width: 75%;
              padding-left:30px;
              padding-right:30px;

}
.common-tagging1.small-common-tag.monotag {padding-top:36px;}
.AR-disclaimer p {font-size:20px!important;line-height:24px!important;}



  /* .clinical-evaluation ul {
  width: 100%;
  margin: 0 auto;
  text-align: left;
}

.section-block-2 ul:last-child {
  margin: 0 auto;
}

.patient-counselling ul {
  width: 100%;
  margin: 0 auto;
  text-align: left;
}

.consider-prescribing ul {
  margin: 0 auto;
  text-align: left;
}

.instruction-4 ul {
  text-align: left;
  width: 84%;
}

.instruction-4 ul ul li {
  text-indent: -10px;
  display: inline-block;
  margin-left: 2px;
}

.anemia-block-2.section-block-2 ul ul li:before {
  content: "-";
  margin: 0 -11px 0 0;
}

.advise-patients-to ul {
  width: 54%;
  margin: 0 auto;
  text-align: left;
}

.constipation-block-2 .consider-prescribing ul {
  width: 40%;
  margin: 0 auto;
  text-align: left;
}

.dysgeusia-block-2 .consider-prescribing ul {
  width: 41%;
  margin: 0 auto;
  text-align: left;
}

.assess-cause ul {
  width: 66%;
  margin: 0 auto;
  text-align: left;
}

.patient-counselling ul ul.dash {
  width: 83%;
  position: relative;
}

.patient-counselling ul ul.dash li {
  text-indent: 0px;
  display: block;
  margin-left: -16px;
}

.patient-counselling ul ul.dash li:before {
  content: "-";
  margin: 4px 5px 0 0;
  position: absolute;
  left: 13px;
}

.fatigue-block-2 .consider-prescribing ul {
  width: 58%;
  margin: 0 auto;
  text-align: left;
}

.headache-block-2 .assess-cause ul {
  width: 20%;
  margin: 0 auto;
  text-align: left;
}

.headache-block-2 .advise-patients-to ul {
  width: 20%;
  margin: 0 auto;
  text-align: left;
}

.headache-block-2 .consider-prescribing ul {
  width: 76%;
  margin: 0 auto;
  text-align: left;
}

.nausea-block-2 .consider-prescribing ul.dash.one {
  padding-bottom: 7px;
}

.nausea-block-2 .consider-prescribing ul.dash {
  padding-bottom: 15px;
}

.section-block ul li {
  display: block;
  margin-left: -23px;
}

.anemia-block-2.section-block-2 ul ul li:before {
  margin: 0 5px 0 0;
}

.fatigue-block-2 .patient-counselling ul ul.dash li {
  text-indent: 0px;
  display: block;
  margin-left: -34px;
}

.fatigue-block-2 .patient-counselling ul ul.dash li:before {
  content: "-";
  margin: 5px 5px 0 0;
  position: absolute;
  left: 3px;
}

.diarrhea-block-2 .consider-prescribing ul {
  width: 18%;
}

.nausea-block-2 .patient-counselling ul ul.dash li {
  margin-left: -34px;
}

.nausea-block-2 .patient-counselling ul ul.dash li:before {
  left: 16px;
}

.dysgeusia-block-2 .patient-counselling ul ul.dash {
  width: 90%;
  position: relative;
} */
  .recommended-dosage p,
  .dose-interruption p {
      position: relative;
      top: 17%;
  }
  .dosing-page .tablets-size {
      top: 13%;
  }
}

.dosing-page .all-caps {
  text-transform: uppercase;
}

.dosing-page .cont {
  text-transform: lowercase;
}

@media only screen and (min-device-width: 768px) and (max-device-width: 1024px) and (orientation: landscape) {
  .dosing-page .doubled-ORR img {
      max-width: 100%;
  }
          .dosing-page .doubled-ORR.patient img {margin-left:0!important;margin-top:12px;}
          .dosing-page .doubled-ORR.studycli img {}
.section-block-1 {padding-top:30px;}
}

@media only screen and (min-device-width: 768px) and (max-device-width: 1024px) and (orientation: portrait) {
.dosing-page .footnote.toremove {
  padding-top: 0;
}
              .dosage .image-scroll {margin-top:0;}
.dosing-nav.bc .anchors li:first-child {margin-left:-18px;}
.ipad {display:block;margin-left:-42px;}
                  .dosing-nav.bc ul li a {padding:10px 0px!important;}
              .dosing-nav.bc ul li:nth-child(1) a {margin-left:20px;}
          .dosing-nav.bc .arrows .arrow-right .arrow-icon::after {right:12px;}
/*.dosing-page .doubled-ORR.patient .image-scroll-inner img.mobile{display:none!important;}*/

.dosing-page .section-block-2 .section-foot .action-cta>div a {
  width: 101%;
}   
.dosing-page .section-block-2 .section-foot .action-cta>div:nth-child(1) {
  margin-right: 3%;
}
.dosing-page .section-block-2 .section-foot .action-cta>div {
  width: 48%;
}
.dosing-page .section-block-2 .section-foot .action-cta>div:nth-child(2) {
  margin-left: 0%;
}
.dosing-page .section-block-2 .section-foot .action-cta>div {
  width: 48%;
}                                                
  .dosing-page #maincontent p.tablets-size {
      font-size: 12px;
  }
  .dosing-page .indent-1 {
      text-indent: -4px;
  }
  .dosing-page .tablets-size {
      padding-top: 20px;
  }
  .dosing-page .footnote {
      padding-top: 25px;
  }
.common-tagging1.small-common-tag.monotag {padding-top:36px;}
.dosecallout.flex_two_three .callout .image img {width:130px;}
.dosecallout.flex_two_one .callout .image img{width:132px;}
.dosecallout.flex_two_two .callout .image img{margin-left:-6px;}
.dosecallout .heading h3::before {padding-top:12px;}
.dosecallout .heading h3{padding-left:36px;}
.dosecallout.flex_two_one .heading h3{padding-left:27px;}
.dosingcallout .col-xs-12:nth-child(1) {padding-left:0px;padding-right:0px;}
.dosingcallout .col-xs-12{padding-right:0px;}
.dosecallout.flex_two_one .heading h3::before {left:-15px;}
.dosecallout.flex_two_two .heading h3::before {left:5px;}
.dosecallout.flex_two_three .heading h3::before {left:5px;}
.dosecallout .callout .text {margin-left:-5px;}
.dosecallout .AR {margin-left:-5px;}
.dosingcallout {margin-left:12px;}
.dosing-page.mono .clinical-studies .image-scroll .mCustomScrollBox img {margin-left:-5%!important;}
.AR-disclaimer.CR {width:70%; margin:25px auto 0px 70px;}
 /* .clinical-evaluation ul {
      width: 79%;
      margin: 0 auto;
      text-align: left;
  }*/
  .section-block-2 ul:last-child {
      margin: 0 auto;
  }
  .dosing-page .section-block-2 .inner-wrapper>div p,
  .dosing-page .section-block-2 .inner-wrapper>div ul {
      margin: 0 auto;
  }
}
 /* .patient-counselling ul {
      width: 71%;
      margin: 0 auto;
      text-align: left;
  }
  .consider-prescribing ul {
      width: 28%;
      margin: 0 auto;
      text-align: left;
  }
  .instruction-4 ul {
      text-align: left;
      width: 84%;
  }
  .instruction-4 ul ul li {
      text-indent: -10px;
      display: inline-block;
      margin-left: 2px;
  }
  .anemia-block-2.section-block-2 ul ul li:before {
      content: "-";
      margin: 0 -11px 0 0;
  }
  .advise-patients-to ul {
      width: 54%;
      margin: 0 auto;
      text-align: left;
  }
  .constipation-block-2 .consider-prescribing ul {
      width: 40%;
      margin: 0 auto;
      text-align: left;
  }
  .dysgeusia-block-2 .consider-prescribing ul {
      width: 27%;
      margin: 0 auto;
      text-align: left;
  }
  .assess-cause ul {
      width: 66%;
      margin: 0 auto;
      text-align: left;
  }
  .patient-counselling ul ul.dash {
      width: 76%;
      position: relative;
  }
  .patient-counselling ul ul.dash li {
      text-indent: 0px;
      display: block;
      margin-left: -16px;
  }
  .patient-counselling ul ul.dash li:before {
      content: "-";
      margin: 4px 5px 0 0;
      position: absolute;
      left: -29px;
  }
  .fatigue-block-2 .consider-prescribing ul {
      width: 58%;
      margin: 0 auto;
      text-align: left;
  }
  .headache-block-2 .assess-cause ul {
      width: 20%;
      margin: 0 auto;
      text-align: left;
  }
  .headache-block-2 .advise-patients-to ul {
      width: 20%;
      margin: 0 auto;
      text-align: left;
  }
  .headache-block-2 .consider-prescribing ul {
      width: 56%;
      margin: 0 auto;
      text-align: left;
  }
  .nausea-block-2 .consider-prescribing ul.dash.one {
      width: 40%;
      padding-bottom: 7px;
  }
  .nausea-block-2 .consider-prescribing ul.dash {
      width: 20%;
      padding-bottom: 15px;
  }
  .section-block ul li {
      /*text-indent: -13px;*/
     /* display: block;
      margin-left: -10px;
  }
  .anemia-block-2.section-block-2 ul ul li:before {
      margin: 0 5px 0 0;
  }
  .fatigue-block-2 .patient-counselling ul ul.dash li {
      text-indent: 0px;
      display: block;
      margin-left: -34px;
  }
  .fatigue-block-2 .patient-counselling ul ul.dash li:before {
      content: "-";
      margin: 0 5px 0 0;
      position: absolute;
      left: -51px;
  }
  .diarrhea-block-2 .consider-prescribing ul {
      width: 21%;
  }
  .nausea-block-2 .patient-counselling ul ul.dash li {
      margin-left: -34px;
  }
  .nausea-block-2 .patient-counselling ul ul.dash li:before {
      left: -51px;
  }
  .dysgeusia-block-2 .patient-counselling ul ul.dash {
      width: 85%;
      position: relative;
  }
  .anemia-block-2 .instruction-4 ul ul li {
      text-indent: -16px;
      display: inline-block;
      margin-left: 7px;
  }
  .anemia-block-2 .instruction-4 ul.dash {
      width: 92%;
  }*/
}


/*Patch by Ramesh**/

.all-caps {
  text-transform: uppercase;
}

.pt10 {
  /*padding-top: 5px !important;*/
  top: -20px !important;
}

section#dysgeusia-block li.inner-list ul li {
  list-style-type: none;
}

section#dysgeusia-block li.inner-list ul li:before {
  content: '-';
  text-indent: -11px;
  display: inline-block;
}

section#dysgeusia-block li.inner-list {
  list-style-type: none;
}

@media only screen and (min-width: 767px) and (max-width: 1023px) {

  .common-tagging1.small-common-tag a span {
     width:85%;
}

}

@media only screen and (max-width:991px) {
  /*section#anemia-block .section-block-2 ul ul {
      list-style: none;
      text-indent: -6px
  }
  section#anemia-block .section-block-2 ul ul li:before {
      content: "-";
      margin: 0 10px 0 0;
  }*/
}


/************************* for IE11/10****************************/

@media screen and (-ms-high-contrast: active),
(-ms-high-contrast: none) {
  .dose-reduction-header.rec-dosage-header {
      min-width: 40%;
  }
  .dose-reduction-body.rec-dosage-body {
      min-width: 38%;
  }
  .olaparib-patient-support .additional-access {
      padding: 14px;
  }
}


/************************For Edge*********************/

@supports (-ms-ime-align:auto) {
  .dose-interruption-body {
      padding: 50px 30px !important;
  }
}
@media (max-width: 340px) {

  .common-tagging1.small-common-tag a {margin-left:-25px;padding: 12px 10px 12px 0px;}
  .AR-disclaimer {width:100%;transform: skewX(-7deg);margin-left:30px;}
      .AR-disclaimer p span {max-width:91%;margin-left:6px;}
  .AR.doubled-ORR {width:80%;}

}
@media (max-width: 360px) {
.AR-disclaimer {width:100%;transform: skewX(-8deg);margin-left:27px;}
.AR-disclaimer p span {max-width:89%;margin-left:6px;}
.AR.doubled-ORR {width:80%;}
}

/****----------samsung 6plus-------************/

@media only screen and (min-device-width : 360px) and (max-device-width : 640px) and (-webkit-min-device-pixel-ratio : 3) { 
.dosing-page .section-block-2 .section-foot .action-cta>div a { width: 99%;}
.dose-img-text-container .dose-img {padding: 5px 0px 5px 9px;}

}

@media only screen and (min-width: 1025px) and (max-width: 1202px){
.dosage.doubled-ORR img{max-width:100%;}
.clinical-studies.doubled-ORR img{max-width:100%;}       
          }
      @media only screen and (min-width: 600px) and (max-width: 767px) {
          .dosing-page .container-center {margin:auto 10px;}


      }